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Integrating the Functional, Psychodynamic, and Immunologic Matrix:  New Adventures in Delayed Food Sensitivity Testing Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute  Adjunct Professor – University of Southern Indiana Adjunct Professor – Indiana University School of Medicine Integrative Medicine for Mental Health Conference Sedona, Arizona September 17-18, 2011
“ There are two objects of medical education: to heal the sick and to advance the science. ” - Dr. Charles H. Mayo, MD “ The glory of medicine is that it is always moving forward, that there is always more to learn.” - Dr. William J. Mayo
Is this any way to take care of the health of a nation? 3.4  Billion   Prescriptions 307  million   People ,[object Object],[object Object],[object Object],[object Object],1. Ukens C. How mail order pharmacy gained in market share in 2003.  Drug Topics  Mar 22, 2004; 148. 2.  U.S. Census Bureau, Jul 2009  3.  CNN Money, May 3, 2010;  http://money.cnn.com/magazines/fortune/ ortune500/2010/industries/21/index.html   accessed August 17, 2011 3.4 * 10  9  Rx 3.1 * 10  8  Peeps
CURRENT PRACTICE OF MEDICINE:  What a patient had to say about her “specialists”: ,[object Object]
Cady Wellness Institute – July 2005 The Reasons: ,[object Object],[object Object],[object Object],[object Object]
 
Triadic model of thinking about diagnosis or treatment puzzles ,[object Object],[object Object],[object Object],[object Object]
How not to get overwhelmed in this presentation:
Stanley E. Greben, MD ,[object Object],[object Object],[object Object],[object Object],“ On Being Therapeutic”  [Canadian Psychiatric Association Journal. Vol. 22(1977) 371-380.
Greben’s “Seven Habits” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],*Requires clinical depth and breadth of knowledge *
Psychodynamics 101 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IMMUNOLOGY The forgotten component of “workups”
[object Object],Lucretius – 099? B.C. – 055? A.D.  De rerum natura.
“ The Three Little Ig’s & Three Stories” ,[object Object],[object Object],[object Object],xciting oing along norant
IgE Antibodies: catastrophic reactions vs. sneezes and itching (checked via skin tests or RAST) http://pathmicro.med.sc.edu/ghaffar/skintest.jpg
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/MastCell.gif www.souzaoenterprises.com/Allergiescomp.jpg CELLULAR immunity
This model of human IgG1 was created by  E. A. Padlan  -- "Anatomy of the Antibody Molecule."  Molecular Immunology   31 :169 (1994)   HUMORAL Immunity “ Globulin molecules capable of attacking the invading agent.” [Guyton]
Actions and downstream effects ,[object Object],[object Object],[object Object],[object Object]
ADHD Diagnosis  ,[object Object],[object Object],[object Object],[object Object]
Medication Is NOT the answer to EVERYTHING! From: www.patientmedia.com (used with permission of William Esteb) However…
Food Allergies and ADHD in the Literature ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Millman, et al – the groundbreaking article ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Oligoantigenic diet (w/o testing) ,[object Object],[object Object],[object Object],[object Object],[object Object]
The  crossover  study –  no distinguishing  between IgE and IgG ,[object Object],[object Object],[object Object],[object Object],[object Object]
Profound cautions ,[object Object],[object Object],[object Object]
The appearance of IgG ,[object Object],[object Object],[object Object],25% - NOT having IgE reactions
“ IgE and Non IgE Food Allergy” ,[object Object],[object Object]
The patient: “Billy” ,[object Object],[object Object],[object Object],[object Object],[object Object]
Billy’s symptoms ,[object Object],[object Object],[object Object],[object Object]
Billy, cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Billy, cont – 1999  - 2000 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Billy, cont.  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Billy, late 2000 ,[object Object],[object Object],[object Object],[object Object],[object Object]
May 2002: 9 th  Annual IFM Conference
Billy, 2003 ,[object Object],[object Object],[object Object],[object Object],[object Object]
Billy – IgG Food Sensitvities July 2003 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Reviewed labs with internet savvy Mom (who did NOTHING).
Billy, 2003 - 2004 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
June 7, 2004 – 6 years of tx; ONE YEAR AFTER IgG Testing! ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Radical interventions/ workup ,[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical manifestations of EFAD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Essential Fatty Acid findings Value Reference range EPA 3 (L) 20 - 80 DHA 32 (L) 70 - 150
 
FEB 2005
Billy – May 3, 2005 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],* Note – not originally seen on testing.
Billy – June 23, 2009 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Status: August 17 2011 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
FROM HYPERNESS TO HEADACHES ,[object Object]
www.pubmed.com  search August 22, 2011 Correlations found between food allergy & : ,[object Object],[object Object],[object Object],[object Object],[object Object]
Gluten – one of the ultimate “bad boys” in food sensitivities ,[object Object],[object Object],[object Object],[object Object],[object Object]
Gluten and neurologic disease ,[object Object],[object Object]
“ UBO’s on MRI” – the gluten connection ,[object Object],[object Object],[object Object],[object Object],[object Object]
Observant pediatricians and depressed parents – with celiac dz
Corvaglia, et al 1999 ,[object Object],[object Object],[object Object],[object Object]
Does it have to be celiac/gluten to mess up your head? Answer: NO! ,[object Object],[object Object],[object Object],[object Object],[object Object]
What to be looking for… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Classic “atypical presentation” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dx, Interventions and Trial Tx ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other dx/tx procedures: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Symptoms at presentation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
More symptoms at presentation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Most relevant labs (ordered before appointment):
 
Interventions and follow-up ,[object Object],[object Object],[object Object]
8/1/2011 follow-up:  strict dairy free diet ,[object Object],[object Object],[object Object],[object Object]
9/13/2011 ,[object Object],[object Object],[object Object],[object Object]
Just one more: Joey -  6/28/11 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dairy IgG sensitivity suspected.  Testing/Results: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What I learned; what we can learn ,[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnostic challenges &  IgG food sensitivities - opportunities exist ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Don’t be a commodity.  Acquaint yourself with diagnostic testing available to you. $3,000 vs. $5,500 – casket and funeral included
"If I hadn't believed it, I wouldn't have seen it." - Yogi Berra Personal collection -  Louis B. Cady, M.D.
Perhaps the ability not only to acquire the confidence of the patient, but  to deserve it,  to see what the patient desires and needs, comes through the sixth sense we call intuition, which in turn comes from  wide experience and deep sympathy for and devotion to the patient , giving to the possessor remarkable ability to achieve results.   ...William J. Mayo, 1935
 
Extra slides for further background follow in notes     Contact info: Louis B. Cady, M.D. www.cadywellness.com   Office: 812-429-0772
Background notions – Greben (appendix) ,[object Object],[object Object],[object Object],“ On Being Therapeutic”  [Canadian Psychiatric Association Journal. Vol. 22(1977) 371-380.
Greben’s conclusions: ,[object Object],[object Object],[object Object],All of this is relevant for the astute clinician physician to improve the communication/ relationship with the patient!
[object Object],[object Object],[object Object],[object Object],[object Object]
Nutrition and ADHD ,[object Object],[object Object]
236 refs July 2005;  315 refs  6/23/09 329 refs Aug 17 2011
10 refs July 2005  6 refs Aug 17, 2011
searched July 16, 2005 Current – 8/17/2011
Fibro, IgG deposits, and "neurogenic inflammation"
Shooting in the dark with milk - 1986... or:  "What do you do if you don't have a test?!"
IgG Food Sensitivities - in "IBS" ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What's out there? 43 refs July 2005 58 on  6/23/2009 66 on 8/18/2011
Celiac disease and suicide reference ,[object Object]

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IgG Food Allergy Testing - Louis B. Cady, M.D.

  • 1. Integrating the Functional, Psychodynamic, and Immunologic Matrix: New Adventures in Delayed Food Sensitivity Testing Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Professor – University of Southern Indiana Adjunct Professor – Indiana University School of Medicine Integrative Medicine for Mental Health Conference Sedona, Arizona September 17-18, 2011
  • 2. “ There are two objects of medical education: to heal the sick and to advance the science. ” - Dr. Charles H. Mayo, MD “ The glory of medicine is that it is always moving forward, that there is always more to learn.” - Dr. William J. Mayo
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  • 8. How not to get overwhelmed in this presentation:
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  • 12. IMMUNOLOGY The forgotten component of “workups”
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  • 15. IgE Antibodies: catastrophic reactions vs. sneezes and itching (checked via skin tests or RAST) http://pathmicro.med.sc.edu/ghaffar/skintest.jpg
  • 17. This model of human IgG1 was created by E. A. Padlan -- "Anatomy of the Antibody Molecule." Molecular Immunology 31 :169 (1994) HUMORAL Immunity “ Globulin molecules capable of attacking the invading agent.” [Guyton]
  • 18.
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  • 20. Medication Is NOT the answer to EVERYTHING! From: www.patientmedia.com (used with permission of William Esteb) However…
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  • 34. May 2002: 9 th Annual IFM Conference
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  • 41. Essential Fatty Acid findings Value Reference range EPA 3 (L) 20 - 80 DHA 32 (L) 70 - 150
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  • 52. Observant pediatricians and depressed parents – with celiac dz
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  • 61. Most relevant labs (ordered before appointment):
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  • 70. Don’t be a commodity. Acquaint yourself with diagnostic testing available to you. $3,000 vs. $5,500 – casket and funeral included
  • 71. "If I hadn't believed it, I wouldn't have seen it." - Yogi Berra Personal collection - Louis B. Cady, M.D.
  • 72. Perhaps the ability not only to acquire the confidence of the patient, but to deserve it, to see what the patient desires and needs, comes through the sixth sense we call intuition, which in turn comes from wide experience and deep sympathy for and devotion to the patient , giving to the possessor remarkable ability to achieve results. ...William J. Mayo, 1935
  • 73.  
  • 74. Extra slides for further background follow in notes  Contact info: Louis B. Cady, M.D. www.cadywellness.com Office: 812-429-0772
  • 75.
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  • 79. 236 refs July 2005; 315 refs 6/23/09 329 refs Aug 17 2011
  • 80. 10 refs July 2005 6 refs Aug 17, 2011
  • 81. searched July 16, 2005 Current – 8/17/2011
  • 82. Fibro, IgG deposits, and "neurogenic inflammation"
  • 83. Shooting in the dark with milk - 1986... or: "What do you do if you don't have a test?!"
  • 84.
  • 85. What's out there? 43 refs July 2005 58 on 6/23/2009 66 on 8/18/2011
  • 86.

Notes de l'éditeur

  1. De rerum natura (English: On the Nature of Things ) is a 1st century BC epic poem by the Roman poet and philosopher Lucretius with the goal of explaining Epicurean philosophy to a Roman audience. The poem, written in dactylic hexameter, is divided into six books, and explores Epicurean physics through richly poetic language and metaphors. Source: Wikipedia
  2. Antibodies to a variety of foods, and in particular cereals, were measured in serum from 100 patients with acute psychoses and 100 elective surgical patients. For 13 out of 14 foods to which non-IgE antibodies were detected the schizophrenics had slightly more antibodies than the controls. There was an association between a possible secondary mania and the presence of IgE antibodies to wheat or rye. However, neither the schizophrenia nor the mania findings can be regarded as evidence for food allergy causing psychiatric disorder , since the immunological findings in both cases may represent consequences of the illnesses or their treatment, rather than causes of the illness.