Seminario biologia mol

RECOMBINANT CLOTTING FACTOR VIII CONCENTRATES: HETEROGENEITY AND HIGH-PURITY EVALUATION Presented by: Luis Miguel Ruiz Velasquez 3rd Semester Medicine Student Lello Zolla

INTRODUCTION ,[object Object],[object Object]

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OBJECTIVE The objective of this study was to compare the heterogeneity and the high purity of both rFVIII preparations before and after thrombin digestion

MATERIALES Y METODOS ,[object Object],[object Object],[object Object],[object Object],[object Object]

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RESULTADOS Figure 1. (A) 1-D SDS-PAGE of three different rFVIII preparations. Forty microgram of each rFVIII was separated on 5–16% w/v ,[object Object],[object Object]

DISCUSSION Reference Agree or disagree What he or she say?

Jankowski et al In the case of Helixate NexGens and Advates, B domain was removed from full-length protein Hansen et al . this cleavage on the precursor could be mediated by cell surface bound proteases Reference Agree or disagree What he or she say?

Reference Agree or disagree What he or she say? Basilico et al The low number of peptides identified in biotechnological preparations could be due to the presence of albumin . agree

CONCLUSIONS ,[object Object],[object Object],[object Object],[object Object]

Seminario biologia mol

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