Antimicrobial Drug Resist.

RED SEA UNIVERSITY FACULTY OF MEDICINE

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],INTRODUCTION:

~Gram –ve  chloramphinicol acetyl transferase against chloramphinicol . b)Microorganism alters its permeability to the drug eg tetracyclin and polymyxin . Streptococci have natural barrier to aminoglycosides . acer:

c)Microorganism develops an altered structural target eg:chromosomal resistance to aminoglycosides “30s ribosomal subunit’’ Erythromycin resistant organisms altere receptors in 50s ribosomal subunit. Penicillin resistance  change in penicillin binding protein “PBP”.

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Origins of the drug resistance ORIGINS Non genetic Genetic chromosomal Extrachromosomal

[object Object],[object Object],[object Object], 1  Non genetic origin:

[object Object],[object Object], 2  Genetic origin :

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Clinical importance of extrachromosomal resistance : ,[object Object],[object Object],[object Object]

The mechanisms of resistance : ,[object Object],[object Object]

Transformation: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Transduction: ,[object Object]

Conjugation (plasmid- mediated transfer): ,[object Object],[object Object]

Transposition: ,[object Object]

cross resistance : ,[object Object],[object Object],[object Object]

Limitation of drug resistance : ,[object Object],[object Object]

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Specific mechanisms of resistance ,[object Object],[object Object],[object Object],[object Object],[object Object]

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MRSA: ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],SYMPTOMS:

Diagnosis and treatment: ,[object Object],[object Object],[object Object],[object Object]

MRSA prevention: ,[object Object],[object Object]

FOR MORE DETAILS: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Web sites: ,[object Object],[object Object],[object Object],[object Object]

Preppared and presented by: ,[object Object],[object Object]

DON’T WORRY.. MEDICINE IS JUST LIKE THIS…!

Antimicrobial Drug Resist.

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Antimicrobial Drug Resist.