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Securing Early Stage
             Funding


David Berry, MD PhD
Partner, Flagship Ventures
Overview

    How does VC work?


    A snapshot of venture capital: then and now


    How to raise money


    Examples in raising money:
          – Friends and family
          – Venture capital
          – Large scale financing


                                                   2


Confidential and Proprietary
A Primer on Venture Capital

    Venture capital firms are managed by a General Partner

    The General Partner invests funds from Limited Partners

    Funds have a ten year life with a limited number of extensions

    The General Partner receives is compensated by a management fee and carry

          – Management fees cover salary and expenses
          – Carry is a percent of the profits

          – Most partnerships have to pay back the LPs and the fees before the General
            Partner can share in the profits

    Incentives vary based on fund size and number of partners

          – Small funds are typically driven by carry only

          – Large funds can be driven by fees

                                                                                         3


Confidential and Proprietary
How Venture Capital Works

    The General Partner invest from the fund into a number of
         companies defined by the strategy
    Typically, subsequent rounds are required after an investment
         by a given VC
          – Existing investors are driven to increase share price and
            reduce dilution
          – VCs are motivated to ‘enhance’ the fundraise
          – The single biggest value of a VC is reducing the cost of
            capital
    Venture capitalists only make a profit upon an IPO or M&A
    Fund life may influence exit behavior


                                                                        4


Confidential and Proprietary
Understanding the VC Incentives

    2 and 20

          – Management fees provide for salaries (2% per year)
          – After the LPs are repaid, 20% of profits (the carry) are split by the GP in a pre-
            defined manner
    VCs are eager to return the fund

    VCs are eager to get disproportionate returns

    Strategies define the motivation

          – Spray and pray

          – Targeted bets
          – Portfolio plays

    Venture capitalists bet on people, trends, IP, and the potential to ‘create value’

                                                                                                 5


Confidential and Proprietary
Venture Capital: A Major Economic Engine




                                                               6


Confidential and Proprietary
Venture Capital is Not Evenly Distributed




                                                                7


Confidential and Proprietary
What Happens to Venture Backed Companies




    Remember: Entrepreneurs Build Companies…VCs just fund them

                                                                  8


Confidential and Proprietary
The Venture Industry Is Now in Challenging
                    Times



                                               Vintage Year   Mean Return (%)

                                                  1999             -1.79
                                                  2000             -1.83
                                                  2001             0.38
                                                  2002             0.83
                                                  2003             3.20
                                                  2004             3.19
                                                  2005             -0.46
                                                  2006             -1.74
                                                  2007             -0.95
                                                  2008             2.20
                                                  2009             2.17




                                                                                9


Confidential and Proprietary
Snapshot on venture backed M&A

    Acquisition volume has decreased, and remains down
            – Transactions over last 10 years are reduced compared to the
              90’s boom
            – Volume has been decreasing on a quarterly basis since 2007
    The average age to acquisition has increased, and remains high

                   M&A Transactions since 2000                                                                        Time from Equity financing to M&A
                                                                                                           8
                                           534      507 524            526
           491
                   460
           $98.3            440                                                                                                                                 6.6
    $100                           410                                        421                    450                                                               6.1
                                                                                      385
                                                                                                                                                         6.0
                                                                                                           6
                                                                                                                                                  5.4                         5.5
                                                                                                                                                                                      5.1
     $75                                                                                      298
                                                                     $61.1                                                                 4.6
                                                                                                     300
                                                                                                           4                        3.7
     $50
                                                           $37.7                                                             2.8
                                            $27.7 $31.5                                                        2.5
                                                                             $26.9                   150
                   $24.0                                                                                               2.1
     $25                                                                             $19.0   $17.7         2
                           $12.1   $14.0


      $0                                                                                             0
           2000    2001     2002   2003      2004   2005   2006      2007    2008    2009     1Q-          0
                                                                                             3Q'10             2000   2001   2002   2003   2004   2005   2006   2007   2008   2009    1Q-
                         Amount Paid ($B)                          Number of Transactions                                                                                            3Q'10
                           Source: Dow Jones VentureSource                                                                          Source: Dow Jones VentureSource                   10


Confidential and Proprietary
IPOs in a mixed environment

    IPOs have returned
           – 2010 activity is the highest since 2007
           – Data is trending higher
    IPOs have an evolving character
           – Higher valuation
           – Flat/less money raised
                                 IPOs since 2000                                                                                 IPO sizes since 2000
        205                                                                                       $500
                                                                                            200
                                                                                                                                                                                              $350

 $25
                                                                                                                                                                                      $395    $300
                                                                                                  $400                                                                         $383
                                                                                                         $367
 $20   $19.0                                                                                150                                                                                               $250
                                                                                                                                                                 $309
                                                                                                  $300            $275                                                  $284
                                                                                                                                                                                              $200
 $15                                                                                                                     $229
                                                                                            100                                  $226    $227
                                                                79                                                                                        $202
                                                                                                  $200                                                                                        $150
                                           67                                                                                                   $166
 $10
                                                       56
                                                44            $7.5                                                        $80                                    $75           $80            $100
                                                                                            50           $76
                                       $5.0                                           32                          $56             $65                                                 $56
  $5                                                                                              $100                                   $51       $50    $52           $54
                 23        20    23                    $3.7
                                                $2.3                                                                                                                                          $50
                                                                       7      8      $2.3
               $1.7     $1.6    $1.5
  $0                                                                                        0       $0                                                                                        $0
                                                                     $0.6   $0.9
       2000    2001     2002    2003   2004     2005   2006   2007   2008   2009     1Q-                 2000     2001    2002    2003   2004      2005   2006   2007   2008   2009    1Q-
                                                                                    3Q'10                                                                                             3Q'10

                      Amount Raised ($B)                      Venture-Backed IPOs                               Median Pre-Valuation at IPO ($M)           Median Amount Raised at IPO ($M)
                        Source: Dow Jones VentureSource                                                                         Source: Dow Jones VentureSource                                     11


Confidential and Proprietary
IPO exits are taking longer

    The amount of time to IPO has consistently risen
    The amount of equity financing prior to IPO is markedly
         increased
    The increase in median valuation does not compensate for the
         increased time and money prior to IPOs

              Time from equity financing to IPO                                                            Money raised prior to IPO
  10
                                                                 8.7            8.8
                                                                                       $75                                $73                                       $72
                                                                        7.9
   8                                                                                                                                           $65
                                                          6.8                                               $57                         $58
                                                   6.2                                                             $55                                $55
                                                                                                                                 $51
   6                           5.7   5.7    5.7                                                     $48
                                                                                       $50   $44
                                                                                                                                                             $43
               4.6
   4                   3.6
       3.1
                                                                                       $25

   2


                                                                                       $0
   0
                                                                                             2000   2001    2002   2003   2004   2005   2006   2007   2008   2009    1Q-
       2000    2001    2002   2003   2004   2005   2006   2007   2008   2009    1Q-
                                                                                                                                                                    3Q'10
                                                                               3Q'10

                      Source: Dow Jones VentureSource                                                        Source: Dow Jones VentureSource                           12


Confidential and Proprietary
The ecosystem is responding

    Entrepreneurs are responding to the changes
    Firms are focusing their efforts

                        $85.5
              $80



              $60

                                $42.5
                                                                                $40.1
              $40
                                                                        $31.2
                                                                $28.7                   $28.6
                                        $19.0           $18.9
              $20                                                                               $13.5
                                                $10.4                                                   $9.2

                $0
                         2000   2001    2002    2003    2004    2005    2006    2007    2008    2009     1Q-
                                                                                                        3Q'10   13


Confidential and Proprietary
How To Raise Money

    3 Rules:
          – Give yourself options
          – Create scarcity
          – Raise money when you don’t need to




                                                 14


Confidential and Proprietary
Give Yourself Options

    Options give you flexibility in any negotiation


    Allows you to better match with your goals


    Flexibility is essential to create options


    Be creative and aggressive




                                                       15


Confidential and Proprietary
Example 1: Wellstone Filters




    Based on the development on dialdehyde starches as effective
         binders of AGEs
          – Removes 96% carcinogens
          – Removes 94% tar
          – Removes 10% nicotine
    Initially commercialized to remove carcinogens from cigarettes
    Funded by angel investment, brought public within 12 months


                                                                      16


Confidential and Proprietary
Create Scarcity

    People want what they cant have


    Investors need to be compelled to have something


    If they feel they can get something at any time, they will wait


    Only 3 in 1000 deals a VC sees get funded—scarcity and
         essentialness are differentiating




                                                                       17


Confidential and Proprietary
LS9: Building a better biofuel



                    High-quality, low-cost drop-in fuels and sustainable
                         chemicals for large and growing markets




             Any                     Most           Unique             Drop-in
          renewable                efficient       one-step        infrastructure
          feedstock               conversion       process          compatibility


Confidential and & Confidential
 Proprietary Proprietary                                                            - 18 -
Fatty Acid Biosynthesis:
The Best Route to Hydrocarbons


     Metabolic Modeling
                                               Fatty Acid Biosynthesis
                                                Preferred pathway
                                                90% energetic efficiency
                                                Commercial productivity
                                                Well characterized
                                                Structurally diverse
                                                Immiscible




                                  Carboxylic           Hydrocarbon chain
                                    acid




Confidential and & Confidential
 Proprietary Proprietary                                                    - 19 -
Synthetic Pathways Enable One Step Conversions




Confidential and & Confidential
 Proprietary Proprietary                         - 20 -
Clear Path to Commercialization


                                                                             Product
                                                                             Revenue

                                                          Break Ground on
                                                          Commercial Plant
    Increasing Value




                                        Demonstration
                                       Scale Production

                         Pilot Plant
                          Success




                           2009             2010              2012           2013 and
                                                                              beyond
Confidential and & Confidential
 Proprietary Proprietary                                                                - 21 -
Joule Unlimited™




                                                                                               or fresh water
                                                                   Solar Fuels and Chemicals
                                                                        Without LimitsTM



     of infrastructure-compatible
     renewable fuels




© 2010 Joule Biotechnologies, Inc., Proprietary and Confidential              22                          www.joulebio.com
Channeling the Power of Photosynthesis to
  Produce Fuels

                                                                   O2




 CO2                                                                    Waste
                                                                         CO2
                                                                                                      Solar Fuel




                                                                             Water                      O2
         Water

                                Nature’s Way                                           Joule’s Way
                Sunlight, CO2, and water make                                   Harnessing nature to produce
                 trees grow and produce O2                                                  fuels

© 2010 Joule Biotechnologies, Inc., Proprietary and Confidential        23                                   www.joulebio.com
Integrating Synthetic Biology with
  Bioreactor Design


                                             Joule’s Proprietary Organism


                                                                           PRODUCT

              Waste CO2



                      SolarConverter




 Waste
 CO2

                                                            Joule Production Facility



© 2010 Joule Biotechnologies, Inc., Proprietary and Confidential                   24   www.joulebio.com
Towards Future of Unlimited Reserves
                        Joule’s current Pilot Plant, Leander, TX        Joule’s New Mexico 1000 Acre SunSprings Diesel Plant
                                                                                            (in process)




© 2010 Joule Biotechnologies, Inc., Proprietary and Confidential   25                                                  www.joulebio.com
Raise Money When You Don’t Need To

    Give your self options


    Give yourself leverage


    Give your self time


    Give yourself opportunity




                                                         26


Confidential and Proprietary
© 2011 Essentient, Inc. Proprietary and Confidential
  2011 Essentient, Inc., Proprietary and Confidential   27   www.essentientinc.com
                                                               www.essentientinc.com
Securing an Essential Nutrient Supply is THE Most
Important Challenge for 21st Century Health




•    The current infrastructure is an enormous resource drain
       –    Agriculture covers >40% of all land
       –    Produces >30% greenhouse gases
       –    Responsible for over 75% of fresh water use
       –    The single greatest driver of land degradation, ground water depletion, habitat destruction, and
            biodiversity loss
•    Yet it cannot sustainably provide nutrition
       –    ~1 billion people are chronically undernourished
       –    Another 2 billion people are poorly nourished
       –    The ‘properly’ nourished often have an inappropriate nutrient balance leading to the major causes of
            developed world mortality: cancer, heart disease, diabetes
•    Nutrition and food security has been lacking needed innovation
© 2011 Essentient, Inc., Proprietary and Confidential   28                                   www.essentientinc.com
Essentient’s Nutrient Proteins will Transform
    Global Nutrition
No requirement for arable land                 No dependency on fresh water    Minimized GHG emissions




  Nutrition tailored to needs                   Reliable, predictable supply      At ultra-low costs




    © 2011 Essentient, Inc., Proprietary and Confidential    29                      www.essentientinc.com
Summary

    Raising money is about matching your offer to funder needs


    Venture capital is a potent source of capital, but not the only one


    Raise money from venture capitalists requires creating the
         sense of need


    There is no one way to get there


    Once you get investment, interests are generally aligned


                                                                           30


Confidential and Proprietary
Thank you!




             3

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Securing Early Stage Capital

  • 1. Securing Early Stage Funding David Berry, MD PhD Partner, Flagship Ventures
  • 2. Overview  How does VC work?  A snapshot of venture capital: then and now  How to raise money  Examples in raising money: – Friends and family – Venture capital – Large scale financing 2 Confidential and Proprietary
  • 3. A Primer on Venture Capital  Venture capital firms are managed by a General Partner  The General Partner invests funds from Limited Partners  Funds have a ten year life with a limited number of extensions  The General Partner receives is compensated by a management fee and carry – Management fees cover salary and expenses – Carry is a percent of the profits – Most partnerships have to pay back the LPs and the fees before the General Partner can share in the profits  Incentives vary based on fund size and number of partners – Small funds are typically driven by carry only – Large funds can be driven by fees 3 Confidential and Proprietary
  • 4. How Venture Capital Works  The General Partner invest from the fund into a number of companies defined by the strategy  Typically, subsequent rounds are required after an investment by a given VC – Existing investors are driven to increase share price and reduce dilution – VCs are motivated to ‘enhance’ the fundraise – The single biggest value of a VC is reducing the cost of capital  Venture capitalists only make a profit upon an IPO or M&A  Fund life may influence exit behavior 4 Confidential and Proprietary
  • 5. Understanding the VC Incentives  2 and 20 – Management fees provide for salaries (2% per year) – After the LPs are repaid, 20% of profits (the carry) are split by the GP in a pre- defined manner  VCs are eager to return the fund  VCs are eager to get disproportionate returns  Strategies define the motivation – Spray and pray – Targeted bets – Portfolio plays  Venture capitalists bet on people, trends, IP, and the potential to ‘create value’ 5 Confidential and Proprietary
  • 6. Venture Capital: A Major Economic Engine 6 Confidential and Proprietary
  • 7. Venture Capital is Not Evenly Distributed 7 Confidential and Proprietary
  • 8. What Happens to Venture Backed Companies  Remember: Entrepreneurs Build Companies…VCs just fund them 8 Confidential and Proprietary
  • 9. The Venture Industry Is Now in Challenging Times Vintage Year Mean Return (%) 1999 -1.79 2000 -1.83 2001 0.38 2002 0.83 2003 3.20 2004 3.19 2005 -0.46 2006 -1.74 2007 -0.95 2008 2.20 2009 2.17 9 Confidential and Proprietary
  • 10. Snapshot on venture backed M&A  Acquisition volume has decreased, and remains down – Transactions over last 10 years are reduced compared to the 90’s boom – Volume has been decreasing on a quarterly basis since 2007  The average age to acquisition has increased, and remains high M&A Transactions since 2000 Time from Equity financing to M&A 8 534 507 524 526 491 460 $98.3 440 6.6 $100 410 421 450 6.1 385 6.0 6 5.4 5.5 5.1 $75 298 $61.1 4.6 300 4 3.7 $50 $37.7 2.8 $27.7 $31.5 2.5 $26.9 150 $24.0 2.1 $25 $19.0 $17.7 2 $12.1 $14.0 $0 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 1Q- 0 3Q'10 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 1Q- Amount Paid ($B) Number of Transactions 3Q'10 Source: Dow Jones VentureSource Source: Dow Jones VentureSource 10 Confidential and Proprietary
  • 11. IPOs in a mixed environment  IPOs have returned – 2010 activity is the highest since 2007 – Data is trending higher  IPOs have an evolving character – Higher valuation – Flat/less money raised IPOs since 2000 IPO sizes since 2000 205 $500 200 $350 $25 $395 $300 $400 $383 $367 $20 $19.0 150 $250 $309 $300 $275 $284 $200 $15 $229 100 $226 $227 79 $202 $200 $150 67 $166 $10 56 44 $7.5 $80 $75 $80 $100 50 $76 $5.0 32 $56 $65 $56 $5 $100 $51 $50 $52 $54 23 20 23 $3.7 $2.3 $50 7 8 $2.3 $1.7 $1.6 $1.5 $0 0 $0 $0 $0.6 $0.9 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 1Q- 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 1Q- 3Q'10 3Q'10 Amount Raised ($B) Venture-Backed IPOs Median Pre-Valuation at IPO ($M) Median Amount Raised at IPO ($M) Source: Dow Jones VentureSource Source: Dow Jones VentureSource 11 Confidential and Proprietary
  • 12. IPO exits are taking longer  The amount of time to IPO has consistently risen  The amount of equity financing prior to IPO is markedly increased  The increase in median valuation does not compensate for the increased time and money prior to IPOs Time from equity financing to IPO Money raised prior to IPO 10 8.7 8.8 $75 $73 $72 7.9 8 $65 6.8 $57 $58 6.2 $55 $55 $51 6 5.7 5.7 5.7 $48 $50 $44 $43 4.6 4 3.6 3.1 $25 2 $0 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 1Q- 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 1Q- 3Q'10 3Q'10 Source: Dow Jones VentureSource Source: Dow Jones VentureSource 12 Confidential and Proprietary
  • 13. The ecosystem is responding  Entrepreneurs are responding to the changes  Firms are focusing their efforts $85.5 $80 $60 $42.5 $40.1 $40 $31.2 $28.7 $28.6 $19.0 $18.9 $20 $13.5 $10.4 $9.2 $0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 1Q- 3Q'10 13 Confidential and Proprietary
  • 14. How To Raise Money  3 Rules: – Give yourself options – Create scarcity – Raise money when you don’t need to 14 Confidential and Proprietary
  • 15. Give Yourself Options  Options give you flexibility in any negotiation  Allows you to better match with your goals  Flexibility is essential to create options  Be creative and aggressive 15 Confidential and Proprietary
  • 16. Example 1: Wellstone Filters  Based on the development on dialdehyde starches as effective binders of AGEs – Removes 96% carcinogens – Removes 94% tar – Removes 10% nicotine  Initially commercialized to remove carcinogens from cigarettes  Funded by angel investment, brought public within 12 months 16 Confidential and Proprietary
  • 17. Create Scarcity  People want what they cant have  Investors need to be compelled to have something  If they feel they can get something at any time, they will wait  Only 3 in 1000 deals a VC sees get funded—scarcity and essentialness are differentiating 17 Confidential and Proprietary
  • 18. LS9: Building a better biofuel High-quality, low-cost drop-in fuels and sustainable chemicals for large and growing markets Any Most Unique Drop-in renewable efficient one-step infrastructure feedstock conversion process compatibility Confidential and & Confidential Proprietary Proprietary - 18 -
  • 19. Fatty Acid Biosynthesis: The Best Route to Hydrocarbons Metabolic Modeling Fatty Acid Biosynthesis  Preferred pathway  90% energetic efficiency  Commercial productivity  Well characterized  Structurally diverse  Immiscible Carboxylic Hydrocarbon chain acid Confidential and & Confidential Proprietary Proprietary - 19 -
  • 20. Synthetic Pathways Enable One Step Conversions Confidential and & Confidential Proprietary Proprietary - 20 -
  • 21. Clear Path to Commercialization Product Revenue Break Ground on Commercial Plant Increasing Value Demonstration Scale Production Pilot Plant Success 2009 2010 2012 2013 and beyond Confidential and & Confidential Proprietary Proprietary - 21 -
  • 22. Joule Unlimited™ or fresh water Solar Fuels and Chemicals Without LimitsTM of infrastructure-compatible renewable fuels © 2010 Joule Biotechnologies, Inc., Proprietary and Confidential 22 www.joulebio.com
  • 23. Channeling the Power of Photosynthesis to Produce Fuels O2 CO2 Waste CO2 Solar Fuel Water O2 Water Nature’s Way Joule’s Way Sunlight, CO2, and water make Harnessing nature to produce trees grow and produce O2 fuels © 2010 Joule Biotechnologies, Inc., Proprietary and Confidential 23 www.joulebio.com
  • 24. Integrating Synthetic Biology with Bioreactor Design Joule’s Proprietary Organism PRODUCT Waste CO2 SolarConverter Waste CO2 Joule Production Facility © 2010 Joule Biotechnologies, Inc., Proprietary and Confidential 24 www.joulebio.com
  • 25. Towards Future of Unlimited Reserves Joule’s current Pilot Plant, Leander, TX Joule’s New Mexico 1000 Acre SunSprings Diesel Plant (in process) © 2010 Joule Biotechnologies, Inc., Proprietary and Confidential 25 www.joulebio.com
  • 26. Raise Money When You Don’t Need To  Give your self options  Give yourself leverage  Give your self time  Give yourself opportunity 26 Confidential and Proprietary
  • 27. © 2011 Essentient, Inc. Proprietary and Confidential 2011 Essentient, Inc., Proprietary and Confidential 27 www.essentientinc.com www.essentientinc.com
  • 28. Securing an Essential Nutrient Supply is THE Most Important Challenge for 21st Century Health • The current infrastructure is an enormous resource drain – Agriculture covers >40% of all land – Produces >30% greenhouse gases – Responsible for over 75% of fresh water use – The single greatest driver of land degradation, ground water depletion, habitat destruction, and biodiversity loss • Yet it cannot sustainably provide nutrition – ~1 billion people are chronically undernourished – Another 2 billion people are poorly nourished – The ‘properly’ nourished often have an inappropriate nutrient balance leading to the major causes of developed world mortality: cancer, heart disease, diabetes • Nutrition and food security has been lacking needed innovation © 2011 Essentient, Inc., Proprietary and Confidential 28 www.essentientinc.com
  • 29. Essentient’s Nutrient Proteins will Transform Global Nutrition No requirement for arable land No dependency on fresh water Minimized GHG emissions Nutrition tailored to needs Reliable, predictable supply At ultra-low costs © 2011 Essentient, Inc., Proprietary and Confidential 29 www.essentientinc.com
  • 30. Summary  Raising money is about matching your offer to funder needs  Venture capital is a potent source of capital, but not the only one  Raise money from venture capitalists requires creating the sense of need  There is no one way to get there  Once you get investment, interests are generally aligned 30 Confidential and Proprietary