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Pre-pubertal
bleeding
MAHMOUD MELEIS, MD
Agenda
 Definition
 Developmental anatomy & physiology
 Causes
 Approach for Management
 Conclusion
Definition
 Bleeding from Genital tract from day 0 till puberty (9-11)
Developmental anatomy &
physiology
3 stages
Infant & toddler
Pre-school &
school-age (3-6
yrs)
Older school age
& pre-teen (7-12)
Infant & toddler
 Affected by maternal Estrogen, passes placenta
 Normally
 Breast buds are present, milky discharge, Mastitis
 Vaginal discharge, epithelium demonstrates E effect
 Vagina 4 cm long, Cx : uterine corpus ration (3:1)
 Anatomy:
 Clitoral hood is prominent, urethral maybe obscured by redundant hymenal
tissue
 Long hymenal tags, normally extending outside vestibule
 Hymen surrounds vaginal orifice & appears circumferential
Examination
 Should engage the child in a distracting conversation
 In toddlers examine when as if changing diaper on parents lap
 Position:
 Hips are flexed and abducted, Dr’s hands placed on each thigh
 Technique:
 Labial separation
 Labial traction
Gently grasps the labia minora with
thumb & forefinger & pull forward &
out to better visualize entire introitus
Preschool & school age
(3-6 yrs)
 H-P-G axis becomes suppressed, hormonal effect on genital structures
recede
 Labia becomes flatter, clitoris less prominent, hymen becomes thinner &
recedes to give a cresent appearance
 Normally:
 Some maintain thickened redundant configuration
 Single or multiple hymenal tags
Examination
 Gain trust of PARENT, if parent is uneasy, child will be uncomfortable
 Position: frog leg position either on table or on parent’s lap
 Technique:
 Labial separation or traction
 Prone knee-chest position
Better visualize vaginal vault because of concern
for a foreign body
Older school age & pre-teen
(7-12)
 Labia minora become a separate layer & join at the posterior commissure
years after onset of menarche
 Vestibular mucosa thickens & gains cobble stone app
 Hymen thickens & develops fimbriations
 PHYSIOLOGICAL leucorrhea precedes menses by 3-6 months
Normal Developmental
Anatomy
Examination
 Actively engage the child, explain anatomy & procedure with pics
 Ask father or other male relatives to leave examination room
 Avoid embarrassment by using drapes instead of taking off all cloths
 Position:
 Frog leg position
 Lithotomy position
Normal Anatomical Variants
 Pigmentation variations NOT to be confused with bruises
 Peri-urethral band with labial traction
 Deep notches or absent areas of hymen in superior ½ of hymen
 An external hymenal ridge & a midline avascular area on the fossa
navicularis (linea alba)
 Diaper rash mash lead to labial fusion starting at posterior introitus,
varying from few mm or so extensive that entire introitus is obscured
External hymenal ridge (arrow) & sleevelike hymen
Causes
Vulvar &
vaginal
Disorders
Vulvovaginitis
Urethral
prolapse
Lichen
sclerosus
Foreign bodies
Trauma
Accidental
injuries
Sexual abuse
Genital Tumors
Adenocarcinoma
Cx or vagina
Ovarian cyst
Hemangioma
Sarcoma
botryodes
Endometrial
shedding
Physiologic
Precocious
puberty
Vulvovaginitis
 VV is the most common gynecological problem in PP girls
Infection
Bacterial
GABHSC (18%)
S.Flexenari (20%)
Pinworm
Dermatological
Irritant
Atopic dermatitis
Contact dermatitisTrauma
Lead to pruritis,
scratching &
bleeding
Vulvovaginitis
1. Bacterial
Group A β-hemolytic
streptococci
Shigella Fexinari
Spread Oral-digital to genital area
(auto-inoculation)
GIT to genital region
History Upper RTI Diarrhea is absent in most
patients
Symptoms Vaginal discharge (92 %)
Itching (45%)
Redness (30%)
Dysuria (19%)
Pain (8%)
Bleeding (5%)
Mucopurulent, malodorous,
bloody discharge
Vulvovaginitis
Vulvovaginitis
2. Dermatological
 Irritant as shampoo, bubble bath, tight clothing
 Acute or chronic dermatitis lead to pruritis, scratching, break down of
skin & bleeding
Urethral prolapse
 Definition: Protrusion of the urethral mucosa through the meatus
forming a hemorrhagic donut shaped mass
 Incidence:
 Average age is 5 years, common is black girls
 Initial diagnosis correct in only 21 % of girls
 Occurs following an episode of increase IAP
 Management:
 Small & urination not obstructed: Sitz bath, topical Estrogen cream for 4-6
weeks, ABs if infections occur (Recurrence 67%)
 Large, necrotic, or urination is obstructed: surgical resection
Urethral prolapse
 The mother of 3 year old girl is concerned because she saw blood in her
underpants, The patient complains of no pain.
 Examination shows the following
 Note the complete circular eversion of the distal urethral mucosa
 Intraoperatively, prolapsed mucosa is excised in quadrants, and the 2
layers of smooth muscle are apposed together.
Lichen sclerosus
 A destructive inflammatory condition causing pruritis
 Ivory colored plaques that bruise easily
 Rx local steroids
Foreign body
 Purulent , foul, bloody discharge
 Does not respond to ABs
 Commonly toilet paper
 Vaginal irrigation or EUA Vaginoscopy for removal
 Investigations: WBC is urine & NEGATIVE urine culture
Endometrial sheddingEndometrialshedding
Physiological
Precocious puberty
Central
Peripheral
Isolated premature
menarc
Physiological
 In neonates
 Due to withdrawal of maternal hormones
 Ceases within the first 7-10 days of life
Precocious puberty
 Definition: appearance of 2ry sexual characters before 8 years of age or
menarche before 10 yrs
Central Peripheral Isolated premature
menarche
Physiologically normal
pubertal dev occurring at
an early age
Dt inappropriate sex H.
secretion or exposure to
exogenous sex steroids
Excessive sensitivity of the
target tissue to low levels
of sex steroids
GnRH dependent GnRH independent
1. Idiopathic 80-90%
2. CNS TR
3. CNS dysfunction
1. Functioning ovarian
tumors or cysts
2. Adrenal tumors, CAH 3.
Chr 1ry hypothyroidism
4. McCune-Albright synd
1. Spontaneous regression
of ovarian cysts
2. Hypothyroidism
3. McCune Albright Synd
Rx of CPP: Rx of cause & GnRH
analogues
Trauma
 Accidental injuries:
 Blunt trauma: (straddle injury…> hematoma)
 Managed conservatively with ice packs
 If it continues to expand…> evacuation & ligation of bleeding vessels
 Penetrating injury:
 Hymenal injury alone:
 If no active bleeding; conservative management
 Active bleeding: indicates involvement of the vagina…> Exploration & repair
under GA to exclude injury to the upper vagina
 If vaginal vault is involved…> Laparotomy
 Bladder & bowel integrity must be confirmed
 Sexual abuse
Trauma
Genital tumors
Vulval
Hemangioma
Wart
Vaginal & Cx
Sarcoma
botryoids
Cx & vaginal
adenosis
Cx polyp
Adenexal
Granulosa cell
tumor
Gonadoblastoma
Teratoma
Vulval tumors
Vulval hemangioma Vulval Wart
Sarcoma botryoides
 Aggressive malignant tumor affecting either vagina, uterus, bladder or
urethra
 Incidence: Most common in children 90% < 5Y
 Classically presents with polypoid mass protruding through vagina
 May present with vaginal bleeding, foul smelling discharge , abdominal
pain
 Rx:
 Chemotherapy followed by
 Surgical resection preserving bladder & rectum
 Post-op radiotherapy
Sarcoma botryoides
Vaginal & Cx adenosis
 Lead to clear cell carcinoma is daughters of mothers who took DES
during pregnancy
Cx polyp
 Rare condition present by vaginal bleeding with maloderous discharge
 Rx: polyp removal & coagulation of base to avoid recurrence
Rare Causes
 1ry hypothyroidism
 CAH
Evaluation of prepubertal girl
with vaginal bleeding
 Hx (duration, quantity, UT symptoms, recent UTI
 Physical examination
 General: Growth & signs of puberty
 Abdominal palpation: masses
 Genital examination
 Investigations:
 Thryroid Fx test
 FSH, LH
 US/MRI
 Bone age
 Vaginoscope under GA
Conclusion
 Vaginal bleeding in premenarchal girls is a rare condition
 But it’s an alarming clinical presentation & always a cause of concern for
parents & medical staff
 Serious medical or sociological problems can underlay this symptom in
young girls
 It requires careful medical evaluation to exclude serious underlying
causes
Conclusion
 Local lesions of the genital tract are the MCC of vaginal bleeding during
the prepubertal period
 Precocious puberty is the 2nd MCC of premenarcheal vaginal bleeding
 Although rare, malignant neoplasms of the genital tract must be
considered
 Vaginoscopy using the hystroscope is very helpful in the evaluation of
young girls with vaginal bleeding
 Prompt and correct diagnosis will lead to successful management
Feel free to Download this
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Prepubertal bleeding

  • 2. Agenda  Definition  Developmental anatomy & physiology  Causes  Approach for Management  Conclusion
  • 3. Definition  Bleeding from Genital tract from day 0 till puberty (9-11)
  • 4. Developmental anatomy & physiology 3 stages Infant & toddler Pre-school & school-age (3-6 yrs) Older school age & pre-teen (7-12)
  • 5. Infant & toddler  Affected by maternal Estrogen, passes placenta  Normally  Breast buds are present, milky discharge, Mastitis  Vaginal discharge, epithelium demonstrates E effect  Vagina 4 cm long, Cx : uterine corpus ration (3:1)
  • 6.  Anatomy:  Clitoral hood is prominent, urethral maybe obscured by redundant hymenal tissue  Long hymenal tags, normally extending outside vestibule  Hymen surrounds vaginal orifice & appears circumferential
  • 7. Examination  Should engage the child in a distracting conversation  In toddlers examine when as if changing diaper on parents lap  Position:  Hips are flexed and abducted, Dr’s hands placed on each thigh  Technique:  Labial separation  Labial traction Gently grasps the labia minora with thumb & forefinger & pull forward & out to better visualize entire introitus
  • 8. Preschool & school age (3-6 yrs)  H-P-G axis becomes suppressed, hormonal effect on genital structures recede  Labia becomes flatter, clitoris less prominent, hymen becomes thinner & recedes to give a cresent appearance  Normally:  Some maintain thickened redundant configuration  Single or multiple hymenal tags
  • 9. Examination  Gain trust of PARENT, if parent is uneasy, child will be uncomfortable  Position: frog leg position either on table or on parent’s lap  Technique:  Labial separation or traction  Prone knee-chest position Better visualize vaginal vault because of concern for a foreign body
  • 10. Older school age & pre-teen (7-12)  Labia minora become a separate layer & join at the posterior commissure years after onset of menarche  Vestibular mucosa thickens & gains cobble stone app  Hymen thickens & develops fimbriations  PHYSIOLOGICAL leucorrhea precedes menses by 3-6 months
  • 12. Examination  Actively engage the child, explain anatomy & procedure with pics  Ask father or other male relatives to leave examination room  Avoid embarrassment by using drapes instead of taking off all cloths  Position:  Frog leg position  Lithotomy position
  • 13. Normal Anatomical Variants  Pigmentation variations NOT to be confused with bruises  Peri-urethral band with labial traction  Deep notches or absent areas of hymen in superior ½ of hymen  An external hymenal ridge & a midline avascular area on the fossa navicularis (linea alba)  Diaper rash mash lead to labial fusion starting at posterior introitus, varying from few mm or so extensive that entire introitus is obscured External hymenal ridge (arrow) & sleevelike hymen
  • 14. Causes Vulvar & vaginal Disorders Vulvovaginitis Urethral prolapse Lichen sclerosus Foreign bodies Trauma Accidental injuries Sexual abuse Genital Tumors Adenocarcinoma Cx or vagina Ovarian cyst Hemangioma Sarcoma botryodes Endometrial shedding Physiologic Precocious puberty
  • 15. Vulvovaginitis  VV is the most common gynecological problem in PP girls Infection Bacterial GABHSC (18%) S.Flexenari (20%) Pinworm Dermatological Irritant Atopic dermatitis Contact dermatitisTrauma Lead to pruritis, scratching & bleeding
  • 16. Vulvovaginitis 1. Bacterial Group A β-hemolytic streptococci Shigella Fexinari Spread Oral-digital to genital area (auto-inoculation) GIT to genital region History Upper RTI Diarrhea is absent in most patients Symptoms Vaginal discharge (92 %) Itching (45%) Redness (30%) Dysuria (19%) Pain (8%) Bleeding (5%) Mucopurulent, malodorous, bloody discharge
  • 18. Vulvovaginitis 2. Dermatological  Irritant as shampoo, bubble bath, tight clothing  Acute or chronic dermatitis lead to pruritis, scratching, break down of skin & bleeding
  • 19. Urethral prolapse  Definition: Protrusion of the urethral mucosa through the meatus forming a hemorrhagic donut shaped mass  Incidence:  Average age is 5 years, common is black girls  Initial diagnosis correct in only 21 % of girls  Occurs following an episode of increase IAP  Management:  Small & urination not obstructed: Sitz bath, topical Estrogen cream for 4-6 weeks, ABs if infections occur (Recurrence 67%)  Large, necrotic, or urination is obstructed: surgical resection
  • 20. Urethral prolapse  The mother of 3 year old girl is concerned because she saw blood in her underpants, The patient complains of no pain.  Examination shows the following  Note the complete circular eversion of the distal urethral mucosa  Intraoperatively, prolapsed mucosa is excised in quadrants, and the 2 layers of smooth muscle are apposed together.
  • 21. Lichen sclerosus  A destructive inflammatory condition causing pruritis  Ivory colored plaques that bruise easily  Rx local steroids
  • 22. Foreign body  Purulent , foul, bloody discharge  Does not respond to ABs  Commonly toilet paper  Vaginal irrigation or EUA Vaginoscopy for removal  Investigations: WBC is urine & NEGATIVE urine culture
  • 24. Physiological  In neonates  Due to withdrawal of maternal hormones  Ceases within the first 7-10 days of life
  • 25. Precocious puberty  Definition: appearance of 2ry sexual characters before 8 years of age or menarche before 10 yrs Central Peripheral Isolated premature menarche Physiologically normal pubertal dev occurring at an early age Dt inappropriate sex H. secretion or exposure to exogenous sex steroids Excessive sensitivity of the target tissue to low levels of sex steroids GnRH dependent GnRH independent 1. Idiopathic 80-90% 2. CNS TR 3. CNS dysfunction 1. Functioning ovarian tumors or cysts 2. Adrenal tumors, CAH 3. Chr 1ry hypothyroidism 4. McCune-Albright synd 1. Spontaneous regression of ovarian cysts 2. Hypothyroidism 3. McCune Albright Synd Rx of CPP: Rx of cause & GnRH analogues
  • 26. Trauma  Accidental injuries:  Blunt trauma: (straddle injury…> hematoma)  Managed conservatively with ice packs  If it continues to expand…> evacuation & ligation of bleeding vessels  Penetrating injury:  Hymenal injury alone:  If no active bleeding; conservative management  Active bleeding: indicates involvement of the vagina…> Exploration & repair under GA to exclude injury to the upper vagina  If vaginal vault is involved…> Laparotomy  Bladder & bowel integrity must be confirmed  Sexual abuse
  • 28. Genital tumors Vulval Hemangioma Wart Vaginal & Cx Sarcoma botryoids Cx & vaginal adenosis Cx polyp Adenexal Granulosa cell tumor Gonadoblastoma Teratoma
  • 30. Sarcoma botryoides  Aggressive malignant tumor affecting either vagina, uterus, bladder or urethra  Incidence: Most common in children 90% < 5Y  Classically presents with polypoid mass protruding through vagina  May present with vaginal bleeding, foul smelling discharge , abdominal pain  Rx:  Chemotherapy followed by  Surgical resection preserving bladder & rectum  Post-op radiotherapy
  • 32. Vaginal & Cx adenosis  Lead to clear cell carcinoma is daughters of mothers who took DES during pregnancy
  • 33. Cx polyp  Rare condition present by vaginal bleeding with maloderous discharge  Rx: polyp removal & coagulation of base to avoid recurrence
  • 34. Rare Causes  1ry hypothyroidism  CAH
  • 35. Evaluation of prepubertal girl with vaginal bleeding  Hx (duration, quantity, UT symptoms, recent UTI  Physical examination  General: Growth & signs of puberty  Abdominal palpation: masses  Genital examination  Investigations:  Thryroid Fx test  FSH, LH  US/MRI  Bone age  Vaginoscope under GA
  • 36. Conclusion  Vaginal bleeding in premenarchal girls is a rare condition  But it’s an alarming clinical presentation & always a cause of concern for parents & medical staff  Serious medical or sociological problems can underlay this symptom in young girls  It requires careful medical evaluation to exclude serious underlying causes
  • 37. Conclusion  Local lesions of the genital tract are the MCC of vaginal bleeding during the prepubertal period  Precocious puberty is the 2nd MCC of premenarcheal vaginal bleeding  Although rare, malignant neoplasms of the genital tract must be considered  Vaginoscopy using the hystroscope is very helpful in the evaluation of young girls with vaginal bleeding  Prompt and correct diagnosis will lead to successful management
  • 38. Feel free to Download this lecture

Notes de l'éditeur

  1. Epithilium shows glycogen & acidic pH
  2. genital examination that requires either physical or psychological force cannot result in accurate examination findings and may lead to fear on the part ofthe patient and her parent
  3. Multiple hymenal tags are evident during examination by using saline or water to float the hymenal tissue Vaginal epithelium shows ovoid epithelial cells Labia minora appears as an extension of clitoral hood & extends only 1/3 of length of labia majora
  4. Must discuss examination in details to the PARENT to avoid cultural & religious views
  5. Vagina elongates & become 8 cm long, vaginal swab is polygonal eopithelial cells Nl lactobacilli & acidic secretions
  6. Add
  7. Such bands oftissue extend from the urethra, creating a false pocket on either side. The pockets can be confused with the actual urethra, which usually appears as a small midline dimple. Sometimes the urethra is dilated, which may present another unexpected configuration. Urethral dilatation is a simple variant and is not a sign of trauma or disease. Perihymenal bands may extend from the hymen to the vestibular wall. Normal as the hymen changes from circumferential to a crescentic configuration Discuss Rx if u want
  8. pics