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DEVELOPMENTS IN TOXICOLOGY SUPPORT FOR THE DRE COMMUNITY Barry K Logan PhD, DABFT National Director of Forensic Services NMS Labs
[object Object],[object Object],Welcome
Oral Fluid Drug Testing for DRE
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Welcome
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],OF Drug Testing
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],History of OF Drug Testing
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],History of OF Drug Testing
DUID Oral Fluid Use Belgium: saliva screening, blood/saliva confirmation Australia: saliva screening (2x), saliva confirmation Germany: saliva/urine testing, blood confirmation UK: FST, blood sampling; no device being used France: saliva screening, blood confirmation Switzerland: Approved for use
DUID Oral Fluid Use OF Specifically Approved in: Alabama Arizona Colorado Indiana Kansas Louisiana Missouri New York North Carolina North Dakota Ohio Oregon South Dakota Utah
Making OF Testing work for DRE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Total OF Drug Test Solution
Total OF Drug Test Solution  ,[object Object],Amps Benzos Opiates Cocaine Methadone Cannabs Amphetamine Diazepam Codeine Benzoylecgonine Methadone THC Methamphetamine  Nordiazepam Morphine Cocaine EDDP THC-COOH MDMA Oxazepam Hydrocodone Cocaethylene MDA Temazepam 6-MAM Chlordiazepoxide Hydromorphone Lorazepam Oxycodone Clonazepam Oxymorphone Alprazolam Dihydrocodeine Midazolam
[object Object],[object Object],[object Object],Total OF Drug Test Solution
[object Object],[object Object],[object Object],Limitations and Solutions
Complements Existing NMS Labs Tests ,[object Object],[object Object],[object Object],[object Object]
Complements Existing DRE Tests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complements Existing NMS Labs Tests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Designer Drugs and Synthetics
Designer Drugs “Bath Salts” ,[object Object],[object Object],[object Object],[object Object]
Available Designer Drug Tests ,[object Object],[object Object]
Available Designer Drug Tests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],8755B/U Hallucinogens Panel (Expanded) includes: 30 more in development!
Available Designer Drug Tests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],As Special Request: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Designer Synthetic Cannabinoids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],JWH-018
Syn Cann:  DRE Case State College, PA Driving Male, 21 yo Five hits “Mr Nice Guy Incense” two hours prior, in a blunt Admits 20mg Zyprexa  one hour prior Minor one car crash into curb Toxicology (Blood) Behavioral Olanzapine JWH-018 10ng/mL 5ng/mL Subject has slurred speech, slow and low Unsteady on feet States he can hardly stand Fell asleep during evaluation Eyes rolled back in his head Poor coordination Cooperative DRE Opinion CNS Depressant/Cannabis
Syn Cann:  DRE Case State College, PA Physiological Male, 21 yo Five hits “Mr Nice Guy Incense” two hours prior, in a blunt Admits 20mg Zyprexa  one hour prior HGN VGN LOC Pulse BP Eyes Pupil size Temp. All six clues, immediate onset Present Present 86 BPM 108/54 Bloodshot Dilated 101 Toxicology (Blood) SFST Olanzapine JWH-018 10ng/mL 5ng/mL OLS Unable to perform WAT Unable to perform DRE Opinion CNS Depressant/Cannabis FTN Unable to perform
Designer Synthetic Cannabinoids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Designer Synthetic Cannabinoids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thank You! www.NMSLabs.com   www.draeger.com
DRE Immunoassay Panel For each of the immunoassay tests run, how often are they positive? Immunoassay Positivity Rate (%) (n=3810 cases) Amphetamines 5.3 Barbiturates 0.2 Benzodiazepines 21.4 Cocaine/Metabolites 11.0 Methadone 3.7 Opiates 13.7 PCP 1.2 Propoxyphene* 0.4 Cannabinoids 47.3
DRE Immunoassay Panel For each of the immunoassay test positives, how often are the confirmations negative? Reflex test All Negative Rate (%) Amphetamines 41.5 Barbiturates 14.5 Benzodiazepines 7.2 Cocaine/Metabolites 24.5 Methadone 8.8 Opiates 15.5 PCP 24.5 Propoxyphene* 23.2 Cannabinoids 42.1
DRE Immunoassay Panel For each of the immunoassay tests run, how often are they positive? Immunoassay Positivity Rate (%) (n=3810 cases) Amphetamines 5.3 Barbiturates 0.2 Benzodiazepines 21.4 Cocaine/Metabolites 11.0 Methadone 3.7 Opiates 13.7 PCP 1.2 Propoxyphene* 0.4 Cannabinoids 47.3
DRE Immunoassay Panel ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Developments in Toxicology Support for the DRE Community

  • 1. DEVELOPMENTS IN TOXICOLOGY SUPPORT FOR THE DRE COMMUNITY Barry K Logan PhD, DABFT National Director of Forensic Services NMS Labs
  • 2.
  • 3. Oral Fluid Drug Testing for DRE
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. DUID Oral Fluid Use Belgium: saliva screening, blood/saliva confirmation Australia: saliva screening (2x), saliva confirmation Germany: saliva/urine testing, blood confirmation UK: FST, blood sampling; no device being used France: saliva screening, blood confirmation Switzerland: Approved for use
  • 9. DUID Oral Fluid Use OF Specifically Approved in: Alabama Arizona Colorado Indiana Kansas Louisiana Missouri New York North Carolina North Dakota Ohio Oregon South Dakota Utah
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18. Designer Drugs and Synthetics
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24. Syn Cann: DRE Case State College, PA Driving Male, 21 yo Five hits “Mr Nice Guy Incense” two hours prior, in a blunt Admits 20mg Zyprexa one hour prior Minor one car crash into curb Toxicology (Blood) Behavioral Olanzapine JWH-018 10ng/mL 5ng/mL Subject has slurred speech, slow and low Unsteady on feet States he can hardly stand Fell asleep during evaluation Eyes rolled back in his head Poor coordination Cooperative DRE Opinion CNS Depressant/Cannabis
  • 25. Syn Cann: DRE Case State College, PA Physiological Male, 21 yo Five hits “Mr Nice Guy Incense” two hours prior, in a blunt Admits 20mg Zyprexa one hour prior HGN VGN LOC Pulse BP Eyes Pupil size Temp. All six clues, immediate onset Present Present 86 BPM 108/54 Bloodshot Dilated 101 Toxicology (Blood) SFST Olanzapine JWH-018 10ng/mL 5ng/mL OLS Unable to perform WAT Unable to perform DRE Opinion CNS Depressant/Cannabis FTN Unable to perform
  • 26.
  • 27.
  • 28. Thank You! www.NMSLabs.com www.draeger.com
  • 29. DRE Immunoassay Panel For each of the immunoassay tests run, how often are they positive? Immunoassay Positivity Rate (%) (n=3810 cases) Amphetamines 5.3 Barbiturates 0.2 Benzodiazepines 21.4 Cocaine/Metabolites 11.0 Methadone 3.7 Opiates 13.7 PCP 1.2 Propoxyphene* 0.4 Cannabinoids 47.3
  • 30. DRE Immunoassay Panel For each of the immunoassay test positives, how often are the confirmations negative? Reflex test All Negative Rate (%) Amphetamines 41.5 Barbiturates 14.5 Benzodiazepines 7.2 Cocaine/Metabolites 24.5 Methadone 8.8 Opiates 15.5 PCP 24.5 Propoxyphene* 23.2 Cannabinoids 42.1
  • 31. DRE Immunoassay Panel For each of the immunoassay tests run, how often are they positive? Immunoassay Positivity Rate (%) (n=3810 cases) Amphetamines 5.3 Barbiturates 0.2 Benzodiazepines 21.4 Cocaine/Metabolites 11.0 Methadone 3.7 Opiates 13.7 PCP 1.2 Propoxyphene* 0.4 Cannabinoids 47.3
  • 32.

Notes de l'éditeur

  1. Henderson (1986) first described a synthetic drug as one which was designed by a clandestine chemist to produce a certain pharmacological response.
  2. Henderson (1986) first described a synthetic drug as one which was designed by a clandestine chemist to produce a certain pharmacological response.
  3. Henderson (1986) first described a synthetic drug as one which was designed by a clandestine chemist to produce a certain pharmacological response.
  4. Henderson (1986) first described a synthetic drug as one which was designed by a clandestine chemist to produce a certain pharmacological response.