Slideshow is from the University of Michigan Medical School's M1 Embryology sequence View additional course materials on Open.Michigan: openmi.ch/med-M1Embryology

1. Author: Catherine Keegan, M.D., Ph.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution – Non-Commercial 3.0 License: http://creativecommons.org/licenses/by-nc/3.0/ We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact open.michigan@umich.edu with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.

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3. Reproductive Embryology Catherine Keegan, M.D., Ph.D. Spring 2009 M1 Embryology

6. Division of the cloacal region 5 weeks 6 weeks 8 weeks Controversy over existence of “urorectal septum” Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

7. The prostate develops as an outgrowth of the urogenital sinus epithelium Urogenital sinus: prostate, bulbourethral gland Ureteric bud: ureter Mesonephric duct: seminal vesicle, vas deferens Larsen. Human Embryology. Philadelphia : Churchill Livingstone/Elsevier, 2009. 4 th ed. ed

10. Developmental abnormalities of the urogenital sinus Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

12. The first 7 weeks of gestation is the indifferent stage Larsen. Human Embryology. Philadelphia : Churchill Livingstone/Elsevier, 2009. 4 th ed. ed

13. Migration of primordial germ cells to urogenital ridges Mesonephric duct = Wollfian duct Paramesonephric duct = Mullerian duct Indifferent stage Source Undetermined Larsen. Human Embryology. Philadelphia : Churchill Livingstone/Elsevier, 2009. 4 th ed. ed

14. Sertoli cells Leydig cells No MIS No Testosterone Sexual Determination Sexual Differentiation Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

15. Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

16. Appendix testis Prostatic utricle Epoophoron Paroophoron Gartner’s cyst Para-mesonephric duct remnants in males Mesonephric duct remnants in females Larsen. Human Embryology. Philadelphia : Churchill Livingstone/Elsevier, 2009. 4 th ed. ed

17. Formation of uterus and vagina Paramesonephric (Mullerian) ducts fuse to form uterus and upper 1/3 of vagina Langman. Medical Embriology. Lippincott, 2004. 9th ed.

19. Virilization of male genitalia Effects of Testosterone and DHT mediated by Androgen Receptors Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

20. Male virilization Blue = DHT Brown = Testosterone Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

21. Formation of external genitalia Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

22. Formation of the urethra Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

23. Hypospadias Normal midline raphe Raphe off center meatus Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. J. Park J. Park

24. Developmental anomalies of the uterus Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

25. Testicular descent 3 rd month Requires Insl3 2 nd month 7 th month term Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.

29. SRY translocation Pairing of X and Y chromosomes in pseudoautosomal region during meiosis Rare crossing over causes translocation of SRY to X chromosome: XY females or XX males Source Undetermined

43. Cases

50. Additional Source Information for more information see: http://open.umich.edu/wiki/CitationPolicy Slide 6: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 7: Larsen. Human Embryology. Philadelphia : Churchill Livingstone/Elsevier, 2009. 4 th ed. Ed Slide 9: Langman. Medical Embriology. Lippincott, 2004. 9th ed. Slide 10: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 12: Larsen. Human Embryology. Philadelphia : Churchill Livingstone/Elsevier, 2009. 4 th ed. Ed Slide 13: Source Undetermined; Larsen. Human Embryology. Philadelphia : Churchill Livingstone/Elsevier, 2009. 4 th ed. Ed Slide 14: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 15: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 16: Larsen. Human Embryology. Philadelphia : Churchill Livingstone/Elsevier, 2009. 4 th ed. Ed Slide 17: Langman. Medical Embriology. Lippincott, 2004. 9th ed. Slide 19: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 20: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 21: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 22: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 23: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed.; John Park (Both images) Slide 24: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 25: Carlson. Human Embryology and Developmental Biology. Elsevier, 2004. 3rd. Ed. Slide 28: Source Undetermined Slide 29: Source Undetermined Slide 30: Source Undetermined Slide 35: John Park Slide 38: John Park Slide 39: John Park