2. INTRODUCTION
• Diabetes mellitus is a clinical syndrome characterised by
hyperglycemia caused by absolute or relative deficiency
of insulin.
• characterized by abnormally elevated blood glucose
level and dysregulation of carbohydrate , protein & lipid
metabolism.
2
3. Etiologic classification of Diabetes
Mellitus
Type 1 diabetes mellitus
• Beta cell destruction usually leading to absolute insulin deficiency
• Immune mediated
• Idiopathic
Type 2 diabetes mellitus
• Insulin resistance and relative deficiency
3
5. Other specific types
• Genetic defects of beta-cell functions
• Decrease of exocrine pancreas
• Endocrinopathies
• Drug or chemical usage
• Infections
5
6. Gestational diabetes mellitus (GDM)
• Defined as any degree of glucose intolerance with onset
or first recognition during pregnancy.
• 4% of pregnancy.
6
7. Classical symptoms of DM
Delayed wound healing
Weight loss
weakness
polyuria polydipsia polyphagia
7
9. Complications
• People with DM have an increased incidence of both
microvascular and macrovascular complications.
Major organs/systems showing changes Long term complications
Cardiovascular system:
heart, brain, blood vessels
Myocardial infarction; atherosclerosis;
hypertension; microangiopathy; cerebral
vascular infarcts; cerebral hemorrhage
Pancreas Islet cell loss; insulitis (Type 1); amyloid (Type 2)
Kidneys Nephrosclerosis; glomerulosclerosis;
arteriosclerosis; pyelonephritis
Eyes Retinopathy; cataracts; glaucoma
Nervous system Autonomic neuropathy; peripheral neuropathy
Peripherals Peripheral vascular atherosclerosis; infections;
gangrene
9
10. Oral manifestations
• Much attention given to heart diseases, kidney diseases, nerve
diseases and eye diseases associated with diabetes.
• Oral complications are often overlooked.
• There is a strong relationship between a person's oral health
and their general health.
• In people with diabetes, the first signs and symptoms of a
medical condition can develop in the mouth.
11
17. Diagnosis
• Random plasma glucose level of 200 mg/dL or greater.
• Fasting plasma glucose level of 126 or greater. (Normal 70-
110 mg/dL)
• Oral glucose tolerance test (OGTT) value in blood of 200 mg or
greater.
• ADA recommend >45 y/o screened every 3 years.
Diabetes Care, 2000
National Institutes of Health, Aug 2001
17
19. Monitoring
Laboratory Evaluation of Diabetes Control:
Glycosylated Hemoglobin Assay (Hb A1c)
4 – 6% Normal
<7% Good Diabetes Control
7 – 8% Moderate Diabetes Control
>8% Action suggested to improve
diabetes control
American Diabetes Association Guidelines 19
27. Dental management considerations
To minimize the risk of an intraoperative emergency,
clinicians need to consider some issues before initiating
dental treatment.
• Medical history: Take history and assess glycemic control at
initial appointment.
• Glucose levels
• Frequency of hypoglycemic episodes
• Medication, dosage and times.
• Consultation
27
28. Dental management considerations
Scheduling of visits
• Morning appointment
• Do not coincide with peak activity.
Diet
• Ensure that the patient has eaten normally and taken medications
as usual.
Prophylactic antibiotics
• Established infection
• Pre-operation contamination wound
• Major surgery
28
29. Dental management considerations
Blood glucose monitoring
• Measured before beginning. (˃70 mg/dL)
During treatment
• The most complication of DM occur is hypoglycemia episode.
• Hyperglycemia
After treatment
• Infection control
• Dietary intake
• Medications : salicylates increase insulin secretion and sensitivity
avoid aspirin.
29
30. Known diabetic patients
• Inquire about the medication, the type, severity and control of
diabetes, the physician treating the patient and the date of last
visit
• The dentist should be aware of the patient’s recent glycated
hemoglobin values.
• HbA1c values of less than 8% indicate relatively good
glycemic control; greater than 10% indicate poor control
• When the level of control of diabetes is not known, consult
patients physician and the treatment should be just limited to
palliation
30
31. Known diabetic patients
• In patients with good glycemic control before starting any
procedure, verify that the patient has taken medication and
diet as usual
• Patients, receiving good medical management without serious
complications such as renal disease, hypertension, or coronary
atherosclerotic heart disease, can receive any indicated dental
treatment
• Local anesthesia is preferred, but such patients can even be
safely treated in general anesthesia
• Morning appointments should be preferred because this is the
time of high glucose and low insulin activity
• This reduces the risk of hypoglycemic episodes during the
dental procedures 31
32. Known diabetic patients
• Appointments should be of short duration
• a source of glucose such as an orange juice must be
available in the dental office to avoid hypoglycemic
attacks
• Prophylactic antibiotics for patients taking high doses of
insulin to prevent post-operative infection are
recommended
• It's best to do surgery when blood sugar levels are within
normal range
32
33. Known diabetic patients
To avoid hyperglycemia use anxiety reduction
protocol
Emotional stresses and painful conditions
increase the amount of cortisol and epinephrine
secretion which induce hyperglycemia so
• pre-treatment anxiety should be reduced by sedation
• pain during procedures can be avoided by a potent
anesthesia
33
34. Management of Diabetic emergency
• If the dental needs are urgent and blood sugar is poorly
controlled, treatment should be provided in a hospital or
other setting where more medical professionals can
monitor patient
• The most common diabetic emergency which a dentist
encounters is hypoglycemia
• it can lead to life-threatening consequences
• it occurs when the concentration of blood glucose drops
below 60 mg/dL
34
35. Management of Insulin Shock
Insulin shock is a hypoglycemic reaction to over dosage
of insulin, a skipped meal, a strenous exercise by an
insulin dependent diabetic( type I).
Features
• confusion, sweating, tremors, agitation,
• anxiety, dizziness, tingling or numbness, tachycardia.
• Severe hypoglycemia may result in seizures or
loss of consciousness , convulsions and coma.
35
36. Management of Insulin Shock
• As soon as such signs or symptoms are present the dentist
should check the blood glucose with a glucometer.
• Establish adequate airway, breathing & circulation by
loosening dress near the neck, switching on the fan/air
conditioners
• place the patient in the head-low-feet-up position
36
37. Management of Insulin Shock
If patient is conscious and able to take food by
mouth, give 15g of oral carbohydrate in one of
the following forms;
• 4-6 ounce fruit juice or soda,
• 3-4 teaspoon sugar,
• a hard candy.
• Small amount of honey/sweet syrup can also be placed in
the buccal fold
37
38. Management of Insulin Shock
• In unconscious patients, give 50ml of dextrose in 50%
concentration or 1mg glucagon intravenously, or give
1ml glucagon intramuscularly at almost any body site.
• Following treatment, the signs and symptoms of
hypoglycemia should resolve in 10 to 15 minutes
• The patient should be observed for 30 to 60 minutes
after recovery.
• Normal blood glucose level is confirmed by a
glucometer before the patient is allowed to leave
38
40. As soon as such signs or symptoms are present the dentist
should check the blood glucose with a glucometer,, the
“Golden Rule” is that manage the patients as if they are
hypoglycemic until proven otherwise
40
41. Hyperglycemia
Clinical symptoms
• thirst, increased urine output and dehydration.
• progressive reduction in conscious level and
hypotension, with coma and cessation of urine output
in severe cases.
Management
• Primary assessment and resuscitation securing the
airway, breathing and circulation.
• Transport to a hospital facility.
41
42. Post-operative Period
Eating the right diet is a critical part of diabetes therapy,
If the patient is expected to have difficulty in eating solid
food after dental procedure;
Diet should be modified to soft solids or liquids
Even the use of blender to blend food before eating is
recommended
42
43. Post-operative Period
Consult the patient’s physician for post-operative period
diet plan
It is necessary that the total caloric content and
proteins/carbohydrates/fats ratio of the diet remain same
43
44. Instructions to be given to a diabetic
diabetic patients should be strongly motivated to
maintain a good oral hygiene by
• brushing after every meal
• using floss daily
• keeping their dentures clean
44
45. Instructions to be given to a diabetic
patients should be frequently recalled for
• dental examinations
• prophylactic measures, such as topical fluorides should
be applied
45
46. Instructions to be given to a diabetic
Cavities should be treated as quickly as possible.
The dryness of mouth can be relieved by providing
salivary substitutes or
Asking the patient to suck sugar-free candy or gums and
frequently drink water
46
47. Instructions to be given to a diabetic
Because their good oral health can help in maintaining
good glycemic control,
They should be taught that if there is a problem like a
bleeding, swollen or tender gums, continuous bad taste or
white patches,
They should immediately contact a dentist
47
48. Instructions to be given to a diabetic
The patients should be encouraged to quit
smokingas it greatly increases the
risk of periodontal disease in diabetic
patients
48
49. Instructions to be given to a diabetic
Diabetics should be informed that they are more likely to
catch dental diseases than the normal ones.
Awareness and knowledge increases the tendency to seek
preventive dental care, and
Improves chances of maintaining healthy mouth.
49
51. MCQ
• 1)TYPE 1 DM is associated with
a)insulin resistance
b)defect in mitochondrial DNA
c)islet cell auto Antibodies
d)beta cell dysfunction
52. • 2)glycosylated haemoglobin assay(hbA1c)level of
4%_6% indicates
a)normal value
b)good diabetes control
c)moderate diabetes control
d)poor diabetes control
53. • 3)Enzyme deficient in diabetes mellitus is
a)glucokinase
b)hexokinase
c)phosphorylase
d)pyrophosphate dehydrogenase
54. • 4)oral hypoglycemic, which should be stopped prior to
surgery under GA
a)pioglitazone
b)gliclazide
c)metformin
d)glibenclamide
55. • 5)An individual has a fasting blood glucose concentration
of 115 mg/dl on three occasion,what is your conclusion?
a)he is normal
b)he is diabetic
c)he has impaired glucose tolerance
d)he needs further evaluation by other boichemical tests.