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Lecture Notes                                      16
                                      Reproductive System
                                     Diseases and Disorders

Classroom Activity to Accompany
Diseases of the Human Body
Fifth Edition
Carol D. Tamparo   Marcia A. Lewis
Copyright © 2011 by F.A. Davis Company. All rights
reserved. This product is protected by copyright. No part
 of it may be reproduced, stored in a retrieval system, or
  transmitted in any form or by any means—electronic,
  mechanical, photocopying, recording, or otherwise—
       without written permission from the publisher.
Nobody will ever win the battle
of the sexes. There’s too much
 fraternizing with the enemy.

             —Henry A. Kissinger


                                   3
Infertility

• Description
  • Failure to become pregnant after 1 year of
    regular unprotected intercourse, even after
    one or more pregnancies
  • Female fertility peaks at age 24 and
    diminishes after age 30
  • Male fertility peaks at age 25 and declines
    after age 40

                                                  4
Infertility
• Etiology: female
     • Hormonal problems
     • Nutritional deficiencies
     • Tumors
     • Infections
     • Anomalies of the reproductive system


                                              5
Infertility
• Etiology: male
     • Sperm deficiencies
     • Congenital abnormalities
     • Endocrine imbalances
     • Surgical intervention
     • Infection or chronic inflammation of the
       testes, epididymis, vas deferens


                                                  6
Infertility
• Etiology: both sexes
  • Advancing age
  • Heavy alcohol use
  • Drug abuse
  • Obesity (especially in women)
  • Radiation exposure
  • Idiopathic in 10% of cases


                                    7
Infertility
• Signs and symptoms
  • Inability to conceive after 1 year of regular
    unprotected intercourse




                                                    8
Infertility
• Diagnostic procedures: female
    • Complete gynecologic history and physical exam
    • Urinalysis
    • CBC, blood hormone levels
    • Endoscopy
    • X-rays
    • Ultrasound
    • Huhner test: cervical mucus analysis
    • Laparoscopy

                                  CBC = complete blood count.

                                                                9
Infertility
• Diagnostic procedures: male
    • Examination of ejaculate
    • Complete history and physical exam
    • CBC, blood hormone levels
    • Sperm count
    • Urine 17-ketosteroid
    • Cystoscopy and catheterization of ejaculatory
      ducts
    • Vasography
    • Seminal vesiculography

                                                      10
Infertility
• Treatment: female
    • Salpingostomy
    • Lysis of adhesions
    • Removal of ovarian abnormalities
    • Correction of endocrine imbalance
    • Correction of cervicitis
    • Hormone therapy
    • Microsurgery


                                          11
Infertility
• Treatment: male
    • Surgical correction of any abnormality
    • Correction of testicular hypofunction
    • Surgical correction of hydrocele or varicocele
    • Hormone therapy




                                                       12
Infertility
• Treatment
    •   Assisted reproductive therapy (ART)
    •   In vitro fertilization (IVF)
    •   Gamete fallopian transfer (GIFT)
    •   Zygote intrafallopian transfer (ZIFT)
    •   Tubal embryo transplant (TET)




                                                13
Infertility
    Complementary therapy
    • Acupuncture, meditation, guided imagery
    • Yoga
    • Herbal therapy
    Client communication
    • Encourage weight loss
    • Educate about how alcohol and cigarette smoking
      decreases fertility


                                                    14
Infertility
• Prognosis
  • 60% of couples who are treated achieve
    pregnancy
  • Some cases are untreatable
• Prevention
  • Avoid causative factors


                                             15
Sexually Transmitted Diseases




                                16
Common Signs and Symptoms of
Sexually Transmitted Diseases
• Dysuria, hematuria, urinary frequency,
  incontinence, purulent discharge, burning, itching
  on urination
• Pelvic or genital pain
• Any skin ulcerations, especially in genital areas
• Fever, malaise
• Dyspnea


                                                   17
Gonorrhea
• Description
  • Contagious bacterial infection of epithelial
    surfaces of the GU tract
  • Most prevalent among teenagers and young
    adults


                                  GU = genitourinary.



                                                        18
Gonorrhea

• Etiology
  • Bacteria (Neisseria gonorrhoeae) transmitted during
    sexual intercourse or other intimate sexual contact
    with infected partner
  • Bacteria can grow in the mouth, throat, eyes, and
    anus
  • Infected mother can infect infant during vaginal
    delivery



                                                          19
Gonorrhea

• Signs and symptoms
  • Females: may be asymptomatic or present with
    purulent, greenish-yellow discharge from cervix
  • Itching, burning pain
  • Males: purulent, urethral discharge; pain; urinary
    frequency
  • Newborns: gonorrheal ophthalmia neonatorum



                                                         20
Gonorrhea
• Diagnostic procedures
  • Culture and sensitivity of discharge or urine
• Treatment
  • Antibiotics; newer, potent antibiotics
  • Culture after 1 to 2 weeks, 6 months
  • Test for other STDs, also


                                    STDs = sexually transmitted diseases.

                                                                            21
Gonorrhea
   Complementary therapy
   • Stimulate immune system by eliminating fatty
     foods, sugar, white flour, salt, caffeine
   • Vitamin, herbal supplements
   Client communication
   • Practice safer sex
   • Take all medications
   • Return for repeat cultures

                                                    22
Gonorrhea
• Prognosis
  • Good with prompt treatment
  • PID is complication among females
  • Epididymitis is complication among males




                             PID = pelvic inflammatory disease.


                                                                  23
Gonorrhea
• Prevention
  • Use condoms, avoid multiple partners, trace
    sexual partners of infected person
  • Instill 1% silver nitrate solution in newborn’s
    eyes




                                                      24
Genital Herpes
• Description
  • Highly contagious viral infection of genitalia
  • Recurs spontaneously
  • Two stages
     • Active with skin lesions
     • Latent without symptoms



                                                     25
Genital Herpes
• Etiology
  • HSV-1, HSV-2; latter most common genitally
  • Transmitted through direct contact with
    infected bodily secretions during sexual
    intimacy
  • Life-threatening form in infants during vaginal
    birth

                                    HSV = herpes simplex virus.

                                                                  26
Genital Herpes
• Signs and Symptoms
  • Multiple, shallow ulcerations, pustules, or
    erythematous vesicles on genitals, mouth,
    anus
  • Erythema
  • Vesicles rupture causing pain, itching



                                                  27
Genital Herpes
• Diagnostic procedures
  • Physical exam shows lesions
  • Scrapings, biopsy
  • Blood test for antibodies




                                  28
Genital Herpes
• Treatment
  • Treat with valacyclovir
  • Topical medications for edema, pain




                                          29
Genital Herpes
   Complementary therapy
   • Ice pack for erupted sores
   • Cold compress or baking soda to soothe
   • Topical cream
   Client communication
   • Take proper precautions; practice safer sex
   • Alleviate embarrassment



                                                   30
Genital Herpes
• Prognosis
  • No cure
  • 80% with primary genital herpes have
    recurrence within 12 months
  • Associated with cervical cancer




                                           31
Genital Herpes
• Prevention
  • Avoid sexual intercourse and intimacy with
    infected persons
  • Use condoms
  • C-section if mother is infected




                                                 32
Genital Herpes
• Herpes is characterized by multiple
  erythematous
  1. papules
  2. pustules
  3. vesicles
  4. macules

                                        33
Genital Human Papilloma (HPV)
Infection
• Description
  • Most common STD
  • Forty types of HPV that can infect the genital
    areas
  • Genital warts: circumscribed, elevated skin
    lesions, usually seen on the external
    genitalia or near the anus


                                                     34
Genital Human Papilloma (HPV)
Infection
• Etiology
  • Spread by intimate sexual contact
  • Pregnant women can pass the virus to the
    fetus during childbirth
  • Has an incubation of 1 to 6 months




                                               35
Genital Human Papilloma (HPV)
Infection
• Signs and symptoms
  • Most individuals are asymptomatic
  • Warts can be solitary in form or in clusters
  • In males warts at end of the penis or in perianal
    area
  • In females warts appear at vaginal entrance
  • High-risk HPV can cause cervical cancer




                                                        36
Genital Human Papilloma (HPV)
Infection
• Diagnostic procedures
  • Characteristic appearance and location
  • Cervical cell changes can be found during a
    Papanicolaou (Pap) smear




                                                  37
Genital Human Papilloma (HPV)
Infection
• Treatment
  • No treatment
  • A healthy immune system can deter HPV
  • Warts can be removed by carbon dioxide
    laser, cryosurgery, electrocautery,
    debridement
  • Cervical cancer is treatable if detected early


                                                     38
Genital Human Papilloma (HPV)
Infection
   Complementary therapy
   • Ointment of vitamin A and herbs may be applied
     topically – wash hands after application


   Client communication
   • Recommend the use of condoms
   • Encourage annual Pap smears
   • Limit number of sexual partners


                                                      39
Genital Human Papilloma (HPV)
Infection
• Prognosis
  • Low-risk HPV responds well to treatment
  • Prognosis is variable for high-risk HPV or
    cervical cancer
• Prevention
  • HPV vaccine
  • Annual Pap test


                                                 40
Trichomoniasis
• Description
  • Protozoal infection of the vagina, urethra, or
    prostate
  • Common STD — 7.4 million new cases each
    year




                                                     41
Chlamydial Infections
• Description
   • Highly prevalent
   • One of the most potentially damaging STDs in the United
     States
• Etiology
   • Chlamydia trachomatis through vaginal, oral, or anal sexual
     contact with infected person
   • Neonate exposed during delivery may develop conjunctivitis



                                                                   42
Chlamydial Infections
• Signs and symptoms
  • Silent STD; asymptomatic; transmission occurs
    unknowingly
  • Burning, itching in genitalia
  • Mucopurulent vaginal discharge
  • Discharge from penis
  • Burning on urination
  • Swollen scrotum


                                                    43
Chlamydial Infections
• Diagnostic procedures
  • Cytologic, serologic studies of bodily fluids
• Treatment
  • Antibiotics for both partners




                                                    44
Chlamydial Infections
   Complementary therapy
   • Diet that eliminates sugar and includes probiotics
   • Multivitamins
   Client communication
   • Refrain from sexual activity until treatment is
     completed
   • Take all medications



                                                          45
Chlamydial Infections
• Prognosis
  • Good with early treatment
  • If untreated, such complications as PID, infertility in
    females; epididymitis in males; sterility in both
• Prevention
  • Use condoms
  • Contact tracing of intimate partners


                                                              46
Reproductive System
Diseases & Disorders
      in Males



                       47
Common Signs and Symptoms of
Reproductive System Diseases and
Disorders in Males
• Urinary complaints
  • Frequency, urgency, incontinence, dysuria,
    nocturia
  • Pain in any reproductive organ or unusual
    discharge
  • Swelling or enlargement of any reproductive
    organs
  • Any sexual disorder or concern
                                                  48
Benign Prostatic Hyperplasia
• Description
  • An enlarged prostate caused by growth
     •   Cells multiply and squeeze the urethra
     •   Cells grow into urethra and bladder outlet
     •   Common over age 50
     •   Significant if obstructs urinary outflow

• Etiology
     • Due to metabolic, hormonal changes associated with aging



                                                                  49
Benign Prostatic Hyperplasia
• Signs and symptoms
  • Difficulty initiating urination or completely
    emptying bladder
  • Nocturia, urinary frequency
  • Dribbling, weak stream
  • Incontinence


                                                    50
Benign Prostatic Hyperplasia
• Diagnostic procedures
  • Symptoms
  • Digital rectal exam
  • Blood test for PSA and PAP
  • Completion of AUA Prostate Symptom Index
  • Uroflowmetry

  PSA = prostate-specific antigen; PAP = prostatic acid phosphatase; AUA = American Urological Association.


                                                                                                          51
Benign Prostatic Hyperplasia
• Treatment
  • “Watchful waiting”
  • Alpha blocker medications
  • Thermotherapy: microwave or radio
    frequency
  • Transurethral prostate resection (TURP)



                                              52
Benign Prostatic Hyperplasia
   Complementary therapy
   • Avoid caffeine, tobacco, red pepper
   • Herbal remedy from saw palmetto products
   • Add soy and tomatoes to diet
   Client communication
   • Regular prostate exams
   • Discuss sexuality, impotence concerns



                                                53
Benign Prostatic Hyperplasia
• Prognosis
  • Good with proper intervention; 80% to 90% surgical
    success rate
  • Complications include cystitis, dilation of ureters,
    hydronephrosis
• Prevention
  • None
  • Regular prostate exams

                                                           54
Prostatitis
• Description
  • Inflammation of the prostate gland
  • May be acute or chronic
  • Most common in males over age 50
  • Routes of infection through urethra or blood




                                                   55
Epididymitis
• Description
  • Inflammation due to infection
  • Typically unilateral
  • Most common infection of male reproductive
    system
  • Typically affects those ages 19 to 35



                                                 56
Epididymitis
• Etiology
  • Result of prostatitis, UTI, TB, STDs
  • Chlamydia trachomatis, Neisseria gonorrhoeae
    most common agents



                                         TB = tuberculosis.



                                                              57
Epididymitis
• Signs and symptoms
  •   Epididymis becomes enlarged, hard, tender, painful
  •   Scrotal, groin tenderness
  •   Fever, malaise
  •   “Waddle” walk
• Diagnostic procedures
  • UA with culture and sensitivity
  • Ultrasound


                                                           58
Epididymitis
• Treatment
  • Antibiotics
  • Antimicrobial therapy
  • If STD is cause, treat partner(s)




                                        59
Epididymitis
   Complementary therapy
   • Scrotal support, analgesic
   • Scrotal elevation, cool compress to reduce
     swelling, pain


   Client communication
   • Take all medication, analgesics



                                                  60
Epididymitis
• Prognosis
  • Responds well to therapy
  • Epididymis may be scarred
  • Sterility is threat; orchitis is a complication
  • Mumps vaccine for young males to prevent
    orchitis



                                                      61
Epididymitis
• Prevention
  • Early treatment of UTIs
  • Use condoms




                              62
Epididymitis

• Untreated epididymitis can lead to
  1. incontinence
  2. sterility
  3. testicular cancer
  4. BPH



                                       63
Prostatic Cancer
• Description
  • Generally classified as adenocarcinoma
  • Third leading cause of cancer deaths in
    males
  • Tends to metastasize
  • Rare before age 50



                                              64
Prostatic Cancer
• Etiology
  • Family or race predisposition
  • Exposure to environmental elements
  • Coexisting STDs
  • Endogenous hormonal influence
  • Eating fat-containing animal products


                                            65
Prostatic Cancer
• Signs and symptoms
  • Asymptomatic or symptoms of urinary
    obstruction
  • Dysuria, difficulty voiding
  • Urinary frequency, urinary retention
  • Hematuria, bone pain
  • Weight loss

                                           66
Prostatic Cancer
• Diagnostic procedures
  • Digital rectal exam
  • Biopsy
  • CT scan or ultrasonography
  • PSA blood test
  • AMACR genetic marker
                           AMACR = alpha-methylacyl-CoA racemase.



                                                                    67
Prostatic Cancer
• Treatment
  • Depends on tumor stage/grade
  • Surgical removal
  • Hormonal therapy, radiation, chemotherapy
  • “Watchful waiting” for some older clients




                                                68
Prostatic Cancer
   Complementary therapy
   • Genistein appears to inhibit growth of prostatic
     cancer
   • Cryoablation


   Client communication
   • Explain procedures, any possibility of impotence,
     potential for cure


                                                         69
Prostatic Cancer
• Prognosis
  • The earlier detected, the better the prognosis
• Prevention
  • None




                                                 70
Testicular Cancer
• Description
  • Malignant neoplasm of the testis
  • Affects men under age 40
  • Cryptorchidism may be predisposing factor
  • Cure rate of nearly 90% if caught early




                                                71
Reproductive System
Diseases & Disorders
     in Females


                       72
Common Signs and Symptoms of
Reproductive System Diseases and
Disorders in Females
• Pre-, postmenstrual complaints
  (amenorrhea, dysmenorrhea, oligomenorrhea,
  metrorrhagia; skin changes; psychological
  reactions to hormonal changes)
• Lower abdominal or pelvic pain
• Any abnormal vaginal discharge or itching




                                               73
Common Signs and Symptoms of
Reproductive System Diseases and
Disorders in Females
• Fever
• Dyspareunia or any sexual dysfunction
• Breast changes (unusual swelling, lumpiness,
  mass formation, pain, nipple abnormalities)
• Bloating or fullness




                                                 74
Premenstrual Syndrome
• Description
  • Distinct cluster of physical, psychological
    symptoms; regularly recur 3 to 14 days
    before menses; relieved by onset
  • 30% to 40% experience mild to severe PMS
  • More frequent in 30s and 40s


                                   PMS = premenstrual syndrome.

                                                            75
Premenstrual Syndrome
• Etiology
  • Multifactorial
  • Water retention, estrogen-progesterone
    imbalance
  • Psychological factors, dietary deficiencies
  • Endorphin level changes



                                                  76
Premenstrual Syndrome
• Signs and symptoms
  • Irritability, anxiety, depression
  • Sleeplessness, fatigue
  • Food cravings, headaches
  • Abdominal bloating
  • Heart palpitations
  • Swollen, tender breasts

                                        77
Premenstrual Syndrome
• Diagnostic procedures
  • Depends on timing of symptoms
  • Keep journal for 3 months to document
  • Blood levels of estrogen, progesterone
  • History and physical examination




                                             78
Premenstrual Syndrome
• Treatment
  •   Multivitamin with high folic acid, calcium, and vitamin D
  •   Reduce salt intake 2 weeks prior to menses
  •   Diuretics, analgesics
  •   Avoid coffee, nicotine, alcohol, simple sugars
  •   Proper diet, exercise, rest




                                                            79
Premenstrual Syndrome
   Complementary therapy
   • Daily exercise
   • Relaxation programs
   • Vitamin B6, vitamin E, calcium, magnesium, zinc
   • Acupuncture
   Client communication
   • Encourage support from family, friends



                                                       80
Premenstrual Syndrome
• Prognosis
  • Variable
  • Chronic condition ceases at menopause
• Prevention
  • None




                                            81
Dysmenorrhea
• Description
  • Pain associated with menstruation
     • Primary: not associated with identifiable pelvic
       disorder
     • Secondary: there is underlying pelvic pathology or
       disease
     • More common in women with early onset of
       menses


                                                        82
Ovarian Cysts and Tumors
• Description
  • Cysts derived from ovarian follicles that do not open
    to release ovum
  • Occur from puberty to menopause
  • True ovarian neoplasms may be benign (teratomas),
    ovarian, or polycystic
  • PCOS is a complex endocrine disorder in females in
    reproductive years

                                   PCOS = polycystic ovarian syndrome.


                                                                         83
Ovarian Cysts and Tumors
• Etiology
  • Unknown
  • Genetics, especially in PCOS
  • Defects in ovary
  • Hypothalamus–pituitary dysfunction
  • Irregular menstrual cycles


                                         84
Ovarian Cysts and Tumors
• Signs and symptoms
  • Asymptomatic with small cysts
  • Large cysts produce pelvic pain, lower-back
    pain
  • Dyspareunia
  • Spasmodic abdominal pain
  • Fever and vomiting

                                                  85
Ovarian Cysts and Tumors
• Diagnostic procedures
  • Ultrasonography
  • CT scan
  • Blood tests for hormone levels




                                     86
Ovarian Cysts and Tumors
• Treatment
  • Cyst may disappear spontaneously
  • Drug-induced ovulation therapy
  • Surgical resection
  • Oral contraceptives to regulate periods,
    encourage ovulation



                                               87
Ovarian Cysts and Tumors
• Ovarian cysts derive from the
  1. fimbriae
  2. epithelium
  3. endometrium
  4. follicles


                                  88
Ovarian Cysts and Tumors
   Complementary therapy
   • Exercise, weight control
   • Vegetarian diet with organic foods
   • Avoid fried foods, coffee, tobacco, alcohol, sugar
   Client communication
   • Educate about disease process
   • Offer support if infertility results



                                                          89
Ovarian Cysts and Tumors
• Prognosis
  • Varies
  • Resultant infertility
  • Chronic nonovulation predisposes to
    endometrial cancer, CV disease
  • Hyperinsulinemia
• Prevention
  • None
                                          CV = cardiovascular.

                                                           90
Endometriosis
• Description
  • Growth of endometrial tissue in areas
    outside the endometrium
  • Responds to hormonal signals but no tissue
    sloughing
  • May lead to scarring of ectopic site



                                                 91
Endometriosis
• Etiology
  • Unknown, perhaps familial
  • Endometrial tissue gets into blood or lymph
  • Dioxin exposure




                                                  92
Endometriosis
• Signs and symptoms
  • Dysmenorrhea, profuse menses
  • Pain in lower back, vagina
  • Pain at ectopic site during menses
  • Dyspareunia
  • Dysuria


                                         93
Endometriosis
• Diagnostic procedures
  • History and physical examination
  • Laparoscopy
  • Palpation
  • Staged from 1 (superficial to minor lesions)
    to 4 (deep involvement, dense adhesions)


                                                   94
Endometriosis
• Treatment
  • Depends on symptoms, desire to have child,
    stage of disease
  • Hormone therapy; pain medications
  • Surgery




                                                 95
Endometriosis
   Complementary therapy
   • Increase essential fatty acids
   • Reduce intake of meat, eggs, dairy products


   Client communication
   • Client support




                                                   96
Endometriosis
• Prognosis
  • Varies with location of ectopic site, severity
    of symptoms
  • Infertility
• Prevention
  • None


                                                     97
Pelvic Inflammatory Disease
• Description
  • Acute or subacute infection of the uterus,
    fallopian tubes, or ovaries
  • May be recurrent or chronic




                                                 98
Pelvic Inflammatory Disease
• Etiology
  • Infections from Neisseria gonorrhoeae or
    Chlamydia trachomatis
  • Infections following parturition
  • Iatrogenic




                                               99
Pelvic Inflammatory Disease
• Signs and symptoms
  • Often asymptomatic, but damage occurs
  • Symptoms include
     •   Sudden pelvic pain
     •   Purulent, foul-smelling discharge
     •   Fever
     •   Sexual dysfunction
     •   Metrorrhea
     •   Rebound pain



                                             100
Pelvic Inflammatory Disease
• Diagnostic procedures
  • Difficult to diagnose
  • Smear of uterine secretions for culture
  • ESR, WBC
  • C-reactive protein (CRP) in the blood
  • Ultrasonography


                       ESR = erythrocyte sedimentation rate; WBC = white blood cell.

                                                                              101
Pelvic Inflammatory Disease
• Treatment
  • Antibiotics
  • Analgesics
  • Bed rest
  • Surgery




                              102
Pelvic Inflammatory Disease
   Complementary Therapy
   •   Abstinence during the infectious stage
   •   Acupuncture for pain
   •   Multivitamins and vitamin C
   •   Castor oil packs warmed and placed on the lower abdomen
   Client Communication
   • Remind client of the importance of taking all medication
   • Educate about possible complications




                                                                103
Pelvic Inflammatory Disease
• Prognosis
  • Good with early treatment
  • Delayed treatment may result in formation of
    scar tissue and adhesions
• Prevention
  • Prompt treatment of an STD


                                               104
Menopause
• Description
  • Not a disease
  • Cessation of menses, ovarian function due to
    decrease in estrogen levels




                                               105
Menopause


  I used to have Saturday night
fever; now I have Saturday night
            hot flashes.

                        —Maxine


                                   106
Menopause
• Etiology
  • Occurs between ages 45 and 55
  • Surgically induced by oophorectomy
  • Also induced by malnutrition, severe stress,
    or disease with hormonal imbalance




                                                   107
Menopause
• Signs and symptoms
  • Menstrual irregularities; flow decreases, then
    ceases
  • Occurs over months or years
  • Night sweats, hot flashes
  • Syncope
  • Tachycardia
  • Loss of skin elasticity
  • Transient psychological symptoms
                                                 108
Menopause

• Diagnostic procedures
  • History and physical examination
  • Screening of blood serum levels of
    estradiol, FSH, LH



                    FSH = follicle-stimulating hormone; LH = luteinizing hormone.



                                                                                    109
Menopause
• Treatment
  • No treatment or some require HRT
  • Antidepressants may lessen symptoms




                          HRT = hormone replacement therapy.



                                                               110
Menopause
   Complementary therapy
   • Avoid spicy food, caffeine, alcohol
   • Increase calcium intake
   • Moderate exercise
   • Acupuncture, yoga, meditation
   Client communication
   • Teach symptoms and treatment options



                                            111
Menopause
• Prognosis
  • Good; recognize mood swings
  • Postmenopausal women may suffer bone
    loss and cholesterol changes
• Prevention
  • None


                                           112
Menopause

• Menopause can be surgically induced
  by
  1. oophorectomy
  2. oophorotomy
  3. salpingectomy
  4. hysterectomy

                                        113
Ovarian Cancer
• Description
  • Sixth most common cancer among females
  • Risk decreases by 60% for women who take
    oral contraceptives for longer than 5 years
  • “Silent killer”




                                              114
Ovarian Cancer
• Etiology
  • Exact cause is unknown
  • Contributing factors
     •   Familial tendency
     •   HRT with only estrogen
     •   Obesity
     •   Use of androgens to treat endometriosis
  • Increased risk for women who carry BRCA1,
    BRCA2, BNC2, or HNPCC genes

                                HNPCC = hereditary nonpolyposis colorectal cancer.

                                                                                     115
Ovarian Cancer
• Signs and symptoms
  • Urinary urgency
  • Pelvic pain
  • Abdominal pressure
  • Fullness and bloating
  • Persistent indigestion or nausea
  • Change in bowel habits


                                       116
Ovarian Cancer
• Signs and symptoms (cont.)
  • Loss of appetite
  • Increased abdominal girth
  • Dyspareunia
  • Lack of energy
  • Low back pain
  • Changes in menstruation

                                117
Ovarian Cancer
• Diagnostic procedures
  •   Clinical evaluation
  •   Complete history and physical
  •   Transvaginal sonography
  •   Abdominal ultrasound
  •   CT scan
  •   Test for HE4 biomarker
  •   Test for protein CA125


                                      118
Ovarian Cancer
• Treatment
  • Dependent on grading and staging
  • Surgery to remove tumor
  • Chemotherapy
  • Immunotherapy
  • Drug Avastin


                                       119
Ovarian Cancer
   Complementary therapy
   • Controlled amino acid therapy
   • Green tea and ginger capsules for nausea
   • Acupuncture, meditation, and aroma therapy

   Client communication
   • Educate clients about staging, typing of cancer, and
     subsequent treatment plans
   • Encourage reporting of treatment side effects




                                                            120
Ovarian Cancer
• Prognosis
  • Dependent upon type and stage of cancer when diagnosed
  • Early detection has a 95% 5-year survival rate
  • If progressed, survival rate is less than 35%
• Prevention
  • Yearly pelvic exam
  • Genetic testing
  • Factors that reduce risk are oral contraceptives, breast feeding
    after pregnancy, tubal ligation or hysterectomy



                                                                   121
Fibrocystic Breasts
• Description
  • Palpable lumps, cysts that fluctuate in size
    with menses
  • Fluid-filled round or oval cysts, fibrosis, and
    hyperplasia of the cells lining the milk ducts
  • Ages 30 to 55




                                                      122
Fibrocystic Breasts
• Etiology
  • Linked to hormonal changes associated with
    ovarian activity
  • Familial




                                             123
Fibrocystic Breasts
• Signs and symptoms
  • Most frequent in upper, outer quadrant of
    breast
  • Widespread lumpiness or localized mass
  • Pain, tenderness, feeling of fullness before
    menses
  • Fluctuating size
  • Nonbloody nipple discharge (rare)

                                                   124
Fibrocystic Breasts
• Diagnostic procedures
  • Monthly breast self-exam
  • Mammogram
  • Ultrasound
  • Biopsy for suspicious area




                                 125
Fibrocystic Breasts
• Treatment
  • Severe pain or large cysts may require
    •   Needle aspiration
    •   Analgesics
    •   Supportive bra to alleviate pain
    •   Restricting caffeine and salt




                                             126
Fibrocystic Breasts
   Complementary therapy
   • Evening primrose oil, 1 capsule 3 times a day
   • Removal of caffeine


   Client communication
   • Teach breast self-exam to determine “normal”
     from “abnormal” lumps



                                                     127
Fibrocystic Breasts
• Prognosis
  • Good
  • Exacerbations may continue until
    menopause
• Prevention
  • Monthly breast self-exams
  • Regular mammography
  • Reduce caffeine in diet

                                       128
Carcinoma of the Breast
• Description
  • Variety of malignant neoplasms of the breast
  • Usually begins in milk-producing glands
  • Most common site of cancer in females




                                               129
Carcinoma of the Breast
• Etiology
  • Unknown
  • Hereditary
  • Higher in women with biopsy-confirmed
    atypical hyperplasia, a long menstrual
    history, obesity after menopause, smoking
  • High-fat diet; little or no exercise


                                                130
Carcinoma of the Breast
• Signs and symptoms
  • Abnormality on mammogram
  • Breast changes such as lump, thickening,
    dimpling, swelling, skin irritation, distortion
  • Nipple discharge
  • Pain, tenderness


                                                      131
Carcinoma of the Breast
• Diagnostic procedures
  • Monthly breast self-exam
  • Mammogram
  • Ultrasound, CT, and MRI
  • Biopsy
  • Staging, typing

                               MRI = magnetic resonance imaging.

                                                           132
Carcinoma of the Breast
• Treatment
  • Depends on stage, type
  • Surgery: lumpectomy or mastectomy
  • Radiation, chemotherapy
  • Hormone therapy




                                        133
Carcinoma of the Breast
   Complementary therapy
   • Enhance immune system
   • Acupuncture, massage, Reiki, tai chi, yoga
   Client communication
   • Educate about all types of treatment
   • Refer to support system




                                                  134
Carcinoma of the Breast
• Prognosis
  • In early stages, prognosis is good, especially
    without metastasis
• Prevention
  • Breast self-exam, regular mammography




                                                 135
Common Symptoms of Diseases
and Disorders of Pregnancy and
Delivery
• Abdominal pain, tenderness, cramping
• Unusual discharge, pink or brown in color,
  or clotted
• Hypertension, rapid weight gain, edema
• Malaise



                                           136
Spontaneous Abortion
• Description
  • Also called miscarriage
  • Expulsion of the fetus before the 20th week of
    pregnancy
  • Incidence is higher in first pregnancy
  • Risk higher in women over age 35



                                                 137
Ectopic Pregnancy
• Description
  • Fertilized ovum implants, grows somewhere
    other than uterine cavity
  • Usually within one fallopian tube




                                                138
Ectopic Pregnancy
• Etiology
  • Scarring, inflammation of fallopian tubes as
    result of infection
  • Congenital tube malformation
  • Endometriosis, PID, tumors




                                                   139
Ectopic Pregnancy
• Signs and symptoms
  • Signs of early pregnancy
  • Abdominal pain, tenderness
  • Slight vaginal bleeding
  • If tube ruptures, severe abdominal pain,
    intra-abdominal bleeding


                                               140
Ectopic Pregnancy
• Diagnostic procedures
  • Pelvic exam
  • History and physical examination
  • Serum pregnancy test
  • Ultrasound
  • Laparoscopy, exploratory laparotomy


                                          141
Ectopic Pregnancy
• Treatment
  • Laparotomy with saving ovary if possible
  • Blood transfusions




                                               142
Ectopic Pregnancy
   Complementary therapy
   • None

   Client communication
   • Support during diagnosis, treatment
     phases



                                           143
Ectopic Pregnancy
• Prognosis
  • With rupture, complications can be life-
    threatening: hemorrhage, shock, peritonitis
• Prevention
  • Prompt treatment of any GU infection




                                                  144
Pregnancy-Induced
 Hypertension
• Description
  • PIH disorder develops during third trimester
  • Occurs more frequently in primigravidae, ages 12 to
    18 or older than age 35 with multiple births
  • Preeclampsia is the nonconvulsive form
  • Eclampsia is the convulsive form with coma




                                                          145
Pregnancy-Induced
Hypertension
• Etiology
  • Unknown
  • Related to malnutrition, especially lack of
    protein
  • Preexisting vascular, renal disease




                                                  146
Pregnancy-Induced
 Hypertension
• Signs and symptoms
  • Preeclampsia              • Eclampsia
    • Hypertension              • Tonic-clonic
                                  convulsions
    • Generalized     edema
                                • Coma
    • Proteinuria
                                • Rales, rhonchi
    • Sudden weight    gain     • Nystagmus
                                • Oliguria, anuria


                                                     147
Pregnancy-Induced
Hypertension
• Diagnostic procedures
  • Elevated, steadily rising blood pressure
  • UA for low levels of placental growth factor
  • Clinical picture




                                                   148
Pregnancy-Induced
Hypertension
• Treatment
  • Preeclampsia: prevent eclampsia, deliver
    normal baby, rest, antihypertensives
  • Eclampsia: hospitalized with intensive care
  • Goal is to manage delivery until 32 to 34
    weeks into pregnancy; then cesarean
    delivery


                                                  149
Pregnancy-Induced
Hypertension
   Complementary therapy
   • None

   Client communication
   • Stress importance of rest during preeclampsia
   • Support during labor, delivery




                                                     150
Pregnancy-Induced
Hypertension
• Prognosis
  • Good with preeclampsia
  • In eclampsia, maternal mortality rate is 15%
• Prevention
  • Adequate nutrition
  • Good prenatal care
  • Control of blood pressure during pregnancy


                                                   151
Pregnancy-Induced
Hypertension
• Eclampsia is the _____ form of PIH.
 1. benign
 2. convulsive
 3. malignant
 4. nonconvulsive


                                        152
Placenta Previa
• Description
  • Placenta is implanted abnormally low in the
    uterus so that it covers all or part of the
    cervical os
  • Placenta may prematurely separate from the
    uterus causing maternal hemorrhage and
    interrupting oxygen flow to the fetus


                                              153
Credits

Publisher: Margaret Biblis
Acquisitions Editor: Andy McPhee
Developmental Editor: Yvonne Gillam, Julie Munden
Backgrounds: Joseph John Clark, Jr.
Production Manager: Sam Rondinelli
Manager of Electronic Product Development: Kirk Pedrick
Electronic Publishing: Frank Musick
The publisher is not responsible for errors of omission or for consequences from application of information in this presentation,
and makes no warranty, expressed or implied, in regard to its content. Any practice described in this presentation should be
applied by the reader in accordance with professional standards of care used with regard to the unique circumstances that may
apply in each situation.




                                                                                                                                    154

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Session 15: Ch 16 PowerPoint Presentation

  • 1. Lecture Notes 16 Reproductive System Diseases and Disorders Classroom Activity to Accompany Diseases of the Human Body Fifth Edition Carol D. Tamparo Marcia A. Lewis
  • 2. Copyright © 2011 by F.A. Davis Company. All rights reserved. This product is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means—electronic, mechanical, photocopying, recording, or otherwise— without written permission from the publisher.
  • 3. Nobody will ever win the battle of the sexes. There’s too much fraternizing with the enemy. —Henry A. Kissinger 3
  • 4. Infertility • Description • Failure to become pregnant after 1 year of regular unprotected intercourse, even after one or more pregnancies • Female fertility peaks at age 24 and diminishes after age 30 • Male fertility peaks at age 25 and declines after age 40 4
  • 5. Infertility • Etiology: female • Hormonal problems • Nutritional deficiencies • Tumors • Infections • Anomalies of the reproductive system 5
  • 6. Infertility • Etiology: male • Sperm deficiencies • Congenital abnormalities • Endocrine imbalances • Surgical intervention • Infection or chronic inflammation of the testes, epididymis, vas deferens 6
  • 7. Infertility • Etiology: both sexes • Advancing age • Heavy alcohol use • Drug abuse • Obesity (especially in women) • Radiation exposure • Idiopathic in 10% of cases 7
  • 8. Infertility • Signs and symptoms • Inability to conceive after 1 year of regular unprotected intercourse 8
  • 9. Infertility • Diagnostic procedures: female • Complete gynecologic history and physical exam • Urinalysis • CBC, blood hormone levels • Endoscopy • X-rays • Ultrasound • Huhner test: cervical mucus analysis • Laparoscopy CBC = complete blood count. 9
  • 10. Infertility • Diagnostic procedures: male • Examination of ejaculate • Complete history and physical exam • CBC, blood hormone levels • Sperm count • Urine 17-ketosteroid • Cystoscopy and catheterization of ejaculatory ducts • Vasography • Seminal vesiculography 10
  • 11. Infertility • Treatment: female • Salpingostomy • Lysis of adhesions • Removal of ovarian abnormalities • Correction of endocrine imbalance • Correction of cervicitis • Hormone therapy • Microsurgery 11
  • 12. Infertility • Treatment: male • Surgical correction of any abnormality • Correction of testicular hypofunction • Surgical correction of hydrocele or varicocele • Hormone therapy 12
  • 13. Infertility • Treatment • Assisted reproductive therapy (ART) • In vitro fertilization (IVF) • Gamete fallopian transfer (GIFT) • Zygote intrafallopian transfer (ZIFT) • Tubal embryo transplant (TET) 13
  • 14. Infertility Complementary therapy • Acupuncture, meditation, guided imagery • Yoga • Herbal therapy Client communication • Encourage weight loss • Educate about how alcohol and cigarette smoking decreases fertility 14
  • 15. Infertility • Prognosis • 60% of couples who are treated achieve pregnancy • Some cases are untreatable • Prevention • Avoid causative factors 15
  • 17. Common Signs and Symptoms of Sexually Transmitted Diseases • Dysuria, hematuria, urinary frequency, incontinence, purulent discharge, burning, itching on urination • Pelvic or genital pain • Any skin ulcerations, especially in genital areas • Fever, malaise • Dyspnea 17
  • 18. Gonorrhea • Description • Contagious bacterial infection of epithelial surfaces of the GU tract • Most prevalent among teenagers and young adults GU = genitourinary. 18
  • 19. Gonorrhea • Etiology • Bacteria (Neisseria gonorrhoeae) transmitted during sexual intercourse or other intimate sexual contact with infected partner • Bacteria can grow in the mouth, throat, eyes, and anus • Infected mother can infect infant during vaginal delivery 19
  • 20. Gonorrhea • Signs and symptoms • Females: may be asymptomatic or present with purulent, greenish-yellow discharge from cervix • Itching, burning pain • Males: purulent, urethral discharge; pain; urinary frequency • Newborns: gonorrheal ophthalmia neonatorum 20
  • 21. Gonorrhea • Diagnostic procedures • Culture and sensitivity of discharge or urine • Treatment • Antibiotics; newer, potent antibiotics • Culture after 1 to 2 weeks, 6 months • Test for other STDs, also STDs = sexually transmitted diseases. 21
  • 22. Gonorrhea Complementary therapy • Stimulate immune system by eliminating fatty foods, sugar, white flour, salt, caffeine • Vitamin, herbal supplements Client communication • Practice safer sex • Take all medications • Return for repeat cultures 22
  • 23. Gonorrhea • Prognosis • Good with prompt treatment • PID is complication among females • Epididymitis is complication among males PID = pelvic inflammatory disease. 23
  • 24. Gonorrhea • Prevention • Use condoms, avoid multiple partners, trace sexual partners of infected person • Instill 1% silver nitrate solution in newborn’s eyes 24
  • 25. Genital Herpes • Description • Highly contagious viral infection of genitalia • Recurs spontaneously • Two stages • Active with skin lesions • Latent without symptoms 25
  • 26. Genital Herpes • Etiology • HSV-1, HSV-2; latter most common genitally • Transmitted through direct contact with infected bodily secretions during sexual intimacy • Life-threatening form in infants during vaginal birth HSV = herpes simplex virus. 26
  • 27. Genital Herpes • Signs and Symptoms • Multiple, shallow ulcerations, pustules, or erythematous vesicles on genitals, mouth, anus • Erythema • Vesicles rupture causing pain, itching 27
  • 28. Genital Herpes • Diagnostic procedures • Physical exam shows lesions • Scrapings, biopsy • Blood test for antibodies 28
  • 29. Genital Herpes • Treatment • Treat with valacyclovir • Topical medications for edema, pain 29
  • 30. Genital Herpes Complementary therapy • Ice pack for erupted sores • Cold compress or baking soda to soothe • Topical cream Client communication • Take proper precautions; practice safer sex • Alleviate embarrassment 30
  • 31. Genital Herpes • Prognosis • No cure • 80% with primary genital herpes have recurrence within 12 months • Associated with cervical cancer 31
  • 32. Genital Herpes • Prevention • Avoid sexual intercourse and intimacy with infected persons • Use condoms • C-section if mother is infected 32
  • 33. Genital Herpes • Herpes is characterized by multiple erythematous 1. papules 2. pustules 3. vesicles 4. macules 33
  • 34. Genital Human Papilloma (HPV) Infection • Description • Most common STD • Forty types of HPV that can infect the genital areas • Genital warts: circumscribed, elevated skin lesions, usually seen on the external genitalia or near the anus 34
  • 35. Genital Human Papilloma (HPV) Infection • Etiology • Spread by intimate sexual contact • Pregnant women can pass the virus to the fetus during childbirth • Has an incubation of 1 to 6 months 35
  • 36. Genital Human Papilloma (HPV) Infection • Signs and symptoms • Most individuals are asymptomatic • Warts can be solitary in form or in clusters • In males warts at end of the penis or in perianal area • In females warts appear at vaginal entrance • High-risk HPV can cause cervical cancer 36
  • 37. Genital Human Papilloma (HPV) Infection • Diagnostic procedures • Characteristic appearance and location • Cervical cell changes can be found during a Papanicolaou (Pap) smear 37
  • 38. Genital Human Papilloma (HPV) Infection • Treatment • No treatment • A healthy immune system can deter HPV • Warts can be removed by carbon dioxide laser, cryosurgery, electrocautery, debridement • Cervical cancer is treatable if detected early 38
  • 39. Genital Human Papilloma (HPV) Infection Complementary therapy • Ointment of vitamin A and herbs may be applied topically – wash hands after application Client communication • Recommend the use of condoms • Encourage annual Pap smears • Limit number of sexual partners 39
  • 40. Genital Human Papilloma (HPV) Infection • Prognosis • Low-risk HPV responds well to treatment • Prognosis is variable for high-risk HPV or cervical cancer • Prevention • HPV vaccine • Annual Pap test 40
  • 41. Trichomoniasis • Description • Protozoal infection of the vagina, urethra, or prostate • Common STD — 7.4 million new cases each year 41
  • 42. Chlamydial Infections • Description • Highly prevalent • One of the most potentially damaging STDs in the United States • Etiology • Chlamydia trachomatis through vaginal, oral, or anal sexual contact with infected person • Neonate exposed during delivery may develop conjunctivitis 42
  • 43. Chlamydial Infections • Signs and symptoms • Silent STD; asymptomatic; transmission occurs unknowingly • Burning, itching in genitalia • Mucopurulent vaginal discharge • Discharge from penis • Burning on urination • Swollen scrotum 43
  • 44. Chlamydial Infections • Diagnostic procedures • Cytologic, serologic studies of bodily fluids • Treatment • Antibiotics for both partners 44
  • 45. Chlamydial Infections Complementary therapy • Diet that eliminates sugar and includes probiotics • Multivitamins Client communication • Refrain from sexual activity until treatment is completed • Take all medications 45
  • 46. Chlamydial Infections • Prognosis • Good with early treatment • If untreated, such complications as PID, infertility in females; epididymitis in males; sterility in both • Prevention • Use condoms • Contact tracing of intimate partners 46
  • 47. Reproductive System Diseases & Disorders in Males 47
  • 48. Common Signs and Symptoms of Reproductive System Diseases and Disorders in Males • Urinary complaints • Frequency, urgency, incontinence, dysuria, nocturia • Pain in any reproductive organ or unusual discharge • Swelling or enlargement of any reproductive organs • Any sexual disorder or concern 48
  • 49. Benign Prostatic Hyperplasia • Description • An enlarged prostate caused by growth • Cells multiply and squeeze the urethra • Cells grow into urethra and bladder outlet • Common over age 50 • Significant if obstructs urinary outflow • Etiology • Due to metabolic, hormonal changes associated with aging 49
  • 50. Benign Prostatic Hyperplasia • Signs and symptoms • Difficulty initiating urination or completely emptying bladder • Nocturia, urinary frequency • Dribbling, weak stream • Incontinence 50
  • 51. Benign Prostatic Hyperplasia • Diagnostic procedures • Symptoms • Digital rectal exam • Blood test for PSA and PAP • Completion of AUA Prostate Symptom Index • Uroflowmetry PSA = prostate-specific antigen; PAP = prostatic acid phosphatase; AUA = American Urological Association. 51
  • 52. Benign Prostatic Hyperplasia • Treatment • “Watchful waiting” • Alpha blocker medications • Thermotherapy: microwave or radio frequency • Transurethral prostate resection (TURP) 52
  • 53. Benign Prostatic Hyperplasia Complementary therapy • Avoid caffeine, tobacco, red pepper • Herbal remedy from saw palmetto products • Add soy and tomatoes to diet Client communication • Regular prostate exams • Discuss sexuality, impotence concerns 53
  • 54. Benign Prostatic Hyperplasia • Prognosis • Good with proper intervention; 80% to 90% surgical success rate • Complications include cystitis, dilation of ureters, hydronephrosis • Prevention • None • Regular prostate exams 54
  • 55. Prostatitis • Description • Inflammation of the prostate gland • May be acute or chronic • Most common in males over age 50 • Routes of infection through urethra or blood 55
  • 56. Epididymitis • Description • Inflammation due to infection • Typically unilateral • Most common infection of male reproductive system • Typically affects those ages 19 to 35 56
  • 57. Epididymitis • Etiology • Result of prostatitis, UTI, TB, STDs • Chlamydia trachomatis, Neisseria gonorrhoeae most common agents TB = tuberculosis. 57
  • 58. Epididymitis • Signs and symptoms • Epididymis becomes enlarged, hard, tender, painful • Scrotal, groin tenderness • Fever, malaise • “Waddle” walk • Diagnostic procedures • UA with culture and sensitivity • Ultrasound 58
  • 59. Epididymitis • Treatment • Antibiotics • Antimicrobial therapy • If STD is cause, treat partner(s) 59
  • 60. Epididymitis Complementary therapy • Scrotal support, analgesic • Scrotal elevation, cool compress to reduce swelling, pain Client communication • Take all medication, analgesics 60
  • 61. Epididymitis • Prognosis • Responds well to therapy • Epididymis may be scarred • Sterility is threat; orchitis is a complication • Mumps vaccine for young males to prevent orchitis 61
  • 62. Epididymitis • Prevention • Early treatment of UTIs • Use condoms 62
  • 63. Epididymitis • Untreated epididymitis can lead to 1. incontinence 2. sterility 3. testicular cancer 4. BPH 63
  • 64. Prostatic Cancer • Description • Generally classified as adenocarcinoma • Third leading cause of cancer deaths in males • Tends to metastasize • Rare before age 50 64
  • 65. Prostatic Cancer • Etiology • Family or race predisposition • Exposure to environmental elements • Coexisting STDs • Endogenous hormonal influence • Eating fat-containing animal products 65
  • 66. Prostatic Cancer • Signs and symptoms • Asymptomatic or symptoms of urinary obstruction • Dysuria, difficulty voiding • Urinary frequency, urinary retention • Hematuria, bone pain • Weight loss 66
  • 67. Prostatic Cancer • Diagnostic procedures • Digital rectal exam • Biopsy • CT scan or ultrasonography • PSA blood test • AMACR genetic marker AMACR = alpha-methylacyl-CoA racemase. 67
  • 68. Prostatic Cancer • Treatment • Depends on tumor stage/grade • Surgical removal • Hormonal therapy, radiation, chemotherapy • “Watchful waiting” for some older clients 68
  • 69. Prostatic Cancer Complementary therapy • Genistein appears to inhibit growth of prostatic cancer • Cryoablation Client communication • Explain procedures, any possibility of impotence, potential for cure 69
  • 70. Prostatic Cancer • Prognosis • The earlier detected, the better the prognosis • Prevention • None 70
  • 71. Testicular Cancer • Description • Malignant neoplasm of the testis • Affects men under age 40 • Cryptorchidism may be predisposing factor • Cure rate of nearly 90% if caught early 71
  • 72. Reproductive System Diseases & Disorders in Females 72
  • 73. Common Signs and Symptoms of Reproductive System Diseases and Disorders in Females • Pre-, postmenstrual complaints (amenorrhea, dysmenorrhea, oligomenorrhea, metrorrhagia; skin changes; psychological reactions to hormonal changes) • Lower abdominal or pelvic pain • Any abnormal vaginal discharge or itching 73
  • 74. Common Signs and Symptoms of Reproductive System Diseases and Disorders in Females • Fever • Dyspareunia or any sexual dysfunction • Breast changes (unusual swelling, lumpiness, mass formation, pain, nipple abnormalities) • Bloating or fullness 74
  • 75. Premenstrual Syndrome • Description • Distinct cluster of physical, psychological symptoms; regularly recur 3 to 14 days before menses; relieved by onset • 30% to 40% experience mild to severe PMS • More frequent in 30s and 40s PMS = premenstrual syndrome. 75
  • 76. Premenstrual Syndrome • Etiology • Multifactorial • Water retention, estrogen-progesterone imbalance • Psychological factors, dietary deficiencies • Endorphin level changes 76
  • 77. Premenstrual Syndrome • Signs and symptoms • Irritability, anxiety, depression • Sleeplessness, fatigue • Food cravings, headaches • Abdominal bloating • Heart palpitations • Swollen, tender breasts 77
  • 78. Premenstrual Syndrome • Diagnostic procedures • Depends on timing of symptoms • Keep journal for 3 months to document • Blood levels of estrogen, progesterone • History and physical examination 78
  • 79. Premenstrual Syndrome • Treatment • Multivitamin with high folic acid, calcium, and vitamin D • Reduce salt intake 2 weeks prior to menses • Diuretics, analgesics • Avoid coffee, nicotine, alcohol, simple sugars • Proper diet, exercise, rest 79
  • 80. Premenstrual Syndrome Complementary therapy • Daily exercise • Relaxation programs • Vitamin B6, vitamin E, calcium, magnesium, zinc • Acupuncture Client communication • Encourage support from family, friends 80
  • 81. Premenstrual Syndrome • Prognosis • Variable • Chronic condition ceases at menopause • Prevention • None 81
  • 82. Dysmenorrhea • Description • Pain associated with menstruation • Primary: not associated with identifiable pelvic disorder • Secondary: there is underlying pelvic pathology or disease • More common in women with early onset of menses 82
  • 83. Ovarian Cysts and Tumors • Description • Cysts derived from ovarian follicles that do not open to release ovum • Occur from puberty to menopause • True ovarian neoplasms may be benign (teratomas), ovarian, or polycystic • PCOS is a complex endocrine disorder in females in reproductive years PCOS = polycystic ovarian syndrome. 83
  • 84. Ovarian Cysts and Tumors • Etiology • Unknown • Genetics, especially in PCOS • Defects in ovary • Hypothalamus–pituitary dysfunction • Irregular menstrual cycles 84
  • 85. Ovarian Cysts and Tumors • Signs and symptoms • Asymptomatic with small cysts • Large cysts produce pelvic pain, lower-back pain • Dyspareunia • Spasmodic abdominal pain • Fever and vomiting 85
  • 86. Ovarian Cysts and Tumors • Diagnostic procedures • Ultrasonography • CT scan • Blood tests for hormone levels 86
  • 87. Ovarian Cysts and Tumors • Treatment • Cyst may disappear spontaneously • Drug-induced ovulation therapy • Surgical resection • Oral contraceptives to regulate periods, encourage ovulation 87
  • 88. Ovarian Cysts and Tumors • Ovarian cysts derive from the 1. fimbriae 2. epithelium 3. endometrium 4. follicles 88
  • 89. Ovarian Cysts and Tumors Complementary therapy • Exercise, weight control • Vegetarian diet with organic foods • Avoid fried foods, coffee, tobacco, alcohol, sugar Client communication • Educate about disease process • Offer support if infertility results 89
  • 90. Ovarian Cysts and Tumors • Prognosis • Varies • Resultant infertility • Chronic nonovulation predisposes to endometrial cancer, CV disease • Hyperinsulinemia • Prevention • None CV = cardiovascular. 90
  • 91. Endometriosis • Description • Growth of endometrial tissue in areas outside the endometrium • Responds to hormonal signals but no tissue sloughing • May lead to scarring of ectopic site 91
  • 92. Endometriosis • Etiology • Unknown, perhaps familial • Endometrial tissue gets into blood or lymph • Dioxin exposure 92
  • 93. Endometriosis • Signs and symptoms • Dysmenorrhea, profuse menses • Pain in lower back, vagina • Pain at ectopic site during menses • Dyspareunia • Dysuria 93
  • 94. Endometriosis • Diagnostic procedures • History and physical examination • Laparoscopy • Palpation • Staged from 1 (superficial to minor lesions) to 4 (deep involvement, dense adhesions) 94
  • 95. Endometriosis • Treatment • Depends on symptoms, desire to have child, stage of disease • Hormone therapy; pain medications • Surgery 95
  • 96. Endometriosis Complementary therapy • Increase essential fatty acids • Reduce intake of meat, eggs, dairy products Client communication • Client support 96
  • 97. Endometriosis • Prognosis • Varies with location of ectopic site, severity of symptoms • Infertility • Prevention • None 97
  • 98. Pelvic Inflammatory Disease • Description • Acute or subacute infection of the uterus, fallopian tubes, or ovaries • May be recurrent or chronic 98
  • 99. Pelvic Inflammatory Disease • Etiology • Infections from Neisseria gonorrhoeae or Chlamydia trachomatis • Infections following parturition • Iatrogenic 99
  • 100. Pelvic Inflammatory Disease • Signs and symptoms • Often asymptomatic, but damage occurs • Symptoms include • Sudden pelvic pain • Purulent, foul-smelling discharge • Fever • Sexual dysfunction • Metrorrhea • Rebound pain 100
  • 101. Pelvic Inflammatory Disease • Diagnostic procedures • Difficult to diagnose • Smear of uterine secretions for culture • ESR, WBC • C-reactive protein (CRP) in the blood • Ultrasonography ESR = erythrocyte sedimentation rate; WBC = white blood cell. 101
  • 102. Pelvic Inflammatory Disease • Treatment • Antibiotics • Analgesics • Bed rest • Surgery 102
  • 103. Pelvic Inflammatory Disease Complementary Therapy • Abstinence during the infectious stage • Acupuncture for pain • Multivitamins and vitamin C • Castor oil packs warmed and placed on the lower abdomen Client Communication • Remind client of the importance of taking all medication • Educate about possible complications 103
  • 104. Pelvic Inflammatory Disease • Prognosis • Good with early treatment • Delayed treatment may result in formation of scar tissue and adhesions • Prevention • Prompt treatment of an STD 104
  • 105. Menopause • Description • Not a disease • Cessation of menses, ovarian function due to decrease in estrogen levels 105
  • 106. Menopause I used to have Saturday night fever; now I have Saturday night hot flashes. —Maxine 106
  • 107. Menopause • Etiology • Occurs between ages 45 and 55 • Surgically induced by oophorectomy • Also induced by malnutrition, severe stress, or disease with hormonal imbalance 107
  • 108. Menopause • Signs and symptoms • Menstrual irregularities; flow decreases, then ceases • Occurs over months or years • Night sweats, hot flashes • Syncope • Tachycardia • Loss of skin elasticity • Transient psychological symptoms 108
  • 109. Menopause • Diagnostic procedures • History and physical examination • Screening of blood serum levels of estradiol, FSH, LH FSH = follicle-stimulating hormone; LH = luteinizing hormone. 109
  • 110. Menopause • Treatment • No treatment or some require HRT • Antidepressants may lessen symptoms HRT = hormone replacement therapy. 110
  • 111. Menopause Complementary therapy • Avoid spicy food, caffeine, alcohol • Increase calcium intake • Moderate exercise • Acupuncture, yoga, meditation Client communication • Teach symptoms and treatment options 111
  • 112. Menopause • Prognosis • Good; recognize mood swings • Postmenopausal women may suffer bone loss and cholesterol changes • Prevention • None 112
  • 113. Menopause • Menopause can be surgically induced by 1. oophorectomy 2. oophorotomy 3. salpingectomy 4. hysterectomy 113
  • 114. Ovarian Cancer • Description • Sixth most common cancer among females • Risk decreases by 60% for women who take oral contraceptives for longer than 5 years • “Silent killer” 114
  • 115. Ovarian Cancer • Etiology • Exact cause is unknown • Contributing factors • Familial tendency • HRT with only estrogen • Obesity • Use of androgens to treat endometriosis • Increased risk for women who carry BRCA1, BRCA2, BNC2, or HNPCC genes HNPCC = hereditary nonpolyposis colorectal cancer. 115
  • 116. Ovarian Cancer • Signs and symptoms • Urinary urgency • Pelvic pain • Abdominal pressure • Fullness and bloating • Persistent indigestion or nausea • Change in bowel habits 116
  • 117. Ovarian Cancer • Signs and symptoms (cont.) • Loss of appetite • Increased abdominal girth • Dyspareunia • Lack of energy • Low back pain • Changes in menstruation 117
  • 118. Ovarian Cancer • Diagnostic procedures • Clinical evaluation • Complete history and physical • Transvaginal sonography • Abdominal ultrasound • CT scan • Test for HE4 biomarker • Test for protein CA125 118
  • 119. Ovarian Cancer • Treatment • Dependent on grading and staging • Surgery to remove tumor • Chemotherapy • Immunotherapy • Drug Avastin 119
  • 120. Ovarian Cancer Complementary therapy • Controlled amino acid therapy • Green tea and ginger capsules for nausea • Acupuncture, meditation, and aroma therapy Client communication • Educate clients about staging, typing of cancer, and subsequent treatment plans • Encourage reporting of treatment side effects 120
  • 121. Ovarian Cancer • Prognosis • Dependent upon type and stage of cancer when diagnosed • Early detection has a 95% 5-year survival rate • If progressed, survival rate is less than 35% • Prevention • Yearly pelvic exam • Genetic testing • Factors that reduce risk are oral contraceptives, breast feeding after pregnancy, tubal ligation or hysterectomy 121
  • 122. Fibrocystic Breasts • Description • Palpable lumps, cysts that fluctuate in size with menses • Fluid-filled round or oval cysts, fibrosis, and hyperplasia of the cells lining the milk ducts • Ages 30 to 55 122
  • 123. Fibrocystic Breasts • Etiology • Linked to hormonal changes associated with ovarian activity • Familial 123
  • 124. Fibrocystic Breasts • Signs and symptoms • Most frequent in upper, outer quadrant of breast • Widespread lumpiness or localized mass • Pain, tenderness, feeling of fullness before menses • Fluctuating size • Nonbloody nipple discharge (rare) 124
  • 125. Fibrocystic Breasts • Diagnostic procedures • Monthly breast self-exam • Mammogram • Ultrasound • Biopsy for suspicious area 125
  • 126. Fibrocystic Breasts • Treatment • Severe pain or large cysts may require • Needle aspiration • Analgesics • Supportive bra to alleviate pain • Restricting caffeine and salt 126
  • 127. Fibrocystic Breasts Complementary therapy • Evening primrose oil, 1 capsule 3 times a day • Removal of caffeine Client communication • Teach breast self-exam to determine “normal” from “abnormal” lumps 127
  • 128. Fibrocystic Breasts • Prognosis • Good • Exacerbations may continue until menopause • Prevention • Monthly breast self-exams • Regular mammography • Reduce caffeine in diet 128
  • 129. Carcinoma of the Breast • Description • Variety of malignant neoplasms of the breast • Usually begins in milk-producing glands • Most common site of cancer in females 129
  • 130. Carcinoma of the Breast • Etiology • Unknown • Hereditary • Higher in women with biopsy-confirmed atypical hyperplasia, a long menstrual history, obesity after menopause, smoking • High-fat diet; little or no exercise 130
  • 131. Carcinoma of the Breast • Signs and symptoms • Abnormality on mammogram • Breast changes such as lump, thickening, dimpling, swelling, skin irritation, distortion • Nipple discharge • Pain, tenderness 131
  • 132. Carcinoma of the Breast • Diagnostic procedures • Monthly breast self-exam • Mammogram • Ultrasound, CT, and MRI • Biopsy • Staging, typing MRI = magnetic resonance imaging. 132
  • 133. Carcinoma of the Breast • Treatment • Depends on stage, type • Surgery: lumpectomy or mastectomy • Radiation, chemotherapy • Hormone therapy 133
  • 134. Carcinoma of the Breast Complementary therapy • Enhance immune system • Acupuncture, massage, Reiki, tai chi, yoga Client communication • Educate about all types of treatment • Refer to support system 134
  • 135. Carcinoma of the Breast • Prognosis • In early stages, prognosis is good, especially without metastasis • Prevention • Breast self-exam, regular mammography 135
  • 136. Common Symptoms of Diseases and Disorders of Pregnancy and Delivery • Abdominal pain, tenderness, cramping • Unusual discharge, pink or brown in color, or clotted • Hypertension, rapid weight gain, edema • Malaise 136
  • 137. Spontaneous Abortion • Description • Also called miscarriage • Expulsion of the fetus before the 20th week of pregnancy • Incidence is higher in first pregnancy • Risk higher in women over age 35 137
  • 138. Ectopic Pregnancy • Description • Fertilized ovum implants, grows somewhere other than uterine cavity • Usually within one fallopian tube 138
  • 139. Ectopic Pregnancy • Etiology • Scarring, inflammation of fallopian tubes as result of infection • Congenital tube malformation • Endometriosis, PID, tumors 139
  • 140. Ectopic Pregnancy • Signs and symptoms • Signs of early pregnancy • Abdominal pain, tenderness • Slight vaginal bleeding • If tube ruptures, severe abdominal pain, intra-abdominal bleeding 140
  • 141. Ectopic Pregnancy • Diagnostic procedures • Pelvic exam • History and physical examination • Serum pregnancy test • Ultrasound • Laparoscopy, exploratory laparotomy 141
  • 142. Ectopic Pregnancy • Treatment • Laparotomy with saving ovary if possible • Blood transfusions 142
  • 143. Ectopic Pregnancy Complementary therapy • None Client communication • Support during diagnosis, treatment phases 143
  • 144. Ectopic Pregnancy • Prognosis • With rupture, complications can be life- threatening: hemorrhage, shock, peritonitis • Prevention • Prompt treatment of any GU infection 144
  • 145. Pregnancy-Induced Hypertension • Description • PIH disorder develops during third trimester • Occurs more frequently in primigravidae, ages 12 to 18 or older than age 35 with multiple births • Preeclampsia is the nonconvulsive form • Eclampsia is the convulsive form with coma 145
  • 146. Pregnancy-Induced Hypertension • Etiology • Unknown • Related to malnutrition, especially lack of protein • Preexisting vascular, renal disease 146
  • 147. Pregnancy-Induced Hypertension • Signs and symptoms • Preeclampsia • Eclampsia • Hypertension • Tonic-clonic convulsions • Generalized edema • Coma • Proteinuria • Rales, rhonchi • Sudden weight gain • Nystagmus • Oliguria, anuria 147
  • 148. Pregnancy-Induced Hypertension • Diagnostic procedures • Elevated, steadily rising blood pressure • UA for low levels of placental growth factor • Clinical picture 148
  • 149. Pregnancy-Induced Hypertension • Treatment • Preeclampsia: prevent eclampsia, deliver normal baby, rest, antihypertensives • Eclampsia: hospitalized with intensive care • Goal is to manage delivery until 32 to 34 weeks into pregnancy; then cesarean delivery 149
  • 150. Pregnancy-Induced Hypertension Complementary therapy • None Client communication • Stress importance of rest during preeclampsia • Support during labor, delivery 150
  • 151. Pregnancy-Induced Hypertension • Prognosis • Good with preeclampsia • In eclampsia, maternal mortality rate is 15% • Prevention • Adequate nutrition • Good prenatal care • Control of blood pressure during pregnancy 151
  • 152. Pregnancy-Induced Hypertension • Eclampsia is the _____ form of PIH. 1. benign 2. convulsive 3. malignant 4. nonconvulsive 152
  • 153. Placenta Previa • Description • Placenta is implanted abnormally low in the uterus so that it covers all or part of the cervical os • Placenta may prematurely separate from the uterus causing maternal hemorrhage and interrupting oxygen flow to the fetus 153
  • 154. Credits Publisher: Margaret Biblis Acquisitions Editor: Andy McPhee Developmental Editor: Yvonne Gillam, Julie Munden Backgrounds: Joseph John Clark, Jr. Production Manager: Sam Rondinelli Manager of Electronic Product Development: Kirk Pedrick Electronic Publishing: Frank Musick The publisher is not responsible for errors of omission or for consequences from application of information in this presentation, and makes no warranty, expressed or implied, in regard to its content. Any practice described in this presentation should be applied by the reader in accordance with professional standards of care used with regard to the unique circumstances that may apply in each situation. 154