1. Liposomes In Drug Delivery
Presented by:
Chinchole Pravin Sonu
)M.PHARM 2nd
SEM(
DEPARTMENT OF PHARMACEUTICS & QUALITY ASSURANCE
R. C. Patel Institute of Pharmaceutical Education and Research,
shirpur.
2. Overview
•Definition of liposomes
•Classification of liposomes
•Structure of liposomes
•Preparation of liposomes
•Purification of liposomes
•Characterization of liposomes
•Liposome-cell interaction
•Liposomes as drug delivery systems
•Targeted Drug Delivery
4. Classification
•Small unilamellar vesicles
(SUV), 25 to 100 nm in size
that consist of a single
bilayer
•Large unilamellar vesicle
(LUV), 100 to 500 nm in
size that consist of a single
bilayer
•Multilamellar vesicle
(MLV), 200 nm to several
microns,that consist of two
or more concentric bilayer
11. Cholesterol
•Because of its rigid steroid ring system which interferes with
motion of fatty acid tails, stabilizes the lipid bilayer and
decrease the leakage of encapsulated drug
27. Liposomes in drug delivery
•Protect the encapsulated drug from metabolic
degradation
•Increase the half-life of drug
•Reduce the systemic toxicity of drugs
•Could be used as sustained release vehicles
•It is possible to target them to selected tissues
or cell
•Biodegradable and biocompatible