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Cerebral palsy
History
• William Little, a British surgeon, first identified Cerebral Palsy
then called ‘Cerebral Paralysis’.
• Sigmund Freud in 1897 suggested that difficult birth was not
the only cause but rather only a symptom of other factors on
the fetal development. Modern research has shown that 75%
of cases were not due to birth asphyxia supporting Freud’s
view even though through the 19th and 20th Centuries.
Little’s view was the accepted explanation.
What is Cerebral Palsy?
• Cerebral palsy (CP) is a group of disorders that
affect a person’s ability to move and maintain
balance and posture.
• CP is the most common motor disability in
childhood.
• Cerebral means having to do with the
brain. Palsy means weakness or problems with
using the muscles.
Pathology
• The following pathological changes can be seen-
• Malformations: hypogenesis and dsygenesis
• Infarction,focal necrosis and selective neuronal necrosis in
brainstem or cortex.
• Periventricular leukomalacia , necrosis and cystic
degeneration of central white matter.
• Degeneration and gliosis of hypothalamus , globus pallidus,
substantia nigra, cerebral white matter and body of corpus
callosum.
• Status marmoratus in caudate nucleus, putamen and
thalamus
• Encephalitis/vasculitis.
• We classify CP according to the main type of
movement disorder involved. Depending on
which areas of the brain are affected, one or
more of the following movement disorders
can occur:
• Stiff muscles (spasticity)
• Uncontrollable movements (dyskinesia)
• Poor balance and coordination (ataxia)
Types of Cerebral Palsy
• Spastic Cerebral Palsy
• The most common type of CP is spastic CP.
Spastic CP affects about 80% of people with
CP.
• People with spastic CP have increased muscle
tone. This means their muscles are stiff and,
as a result, their movements can be awkward.
Spastic CP usually is described by what parts
of the body are affected:
• Spastic diplegia/diparesis―In this type of CP, muscle stiffness is mainly in
the legs, with the arms less affected or not affected at all. People with
spastic diplegia might have difficulty walking because tight hip and leg
muscles cause their legs to pull together, turn inward, and cross at the
knees (also known as scissoring)
• Spastic hemiplegia/hemiparesis―This type of CP affects only one side of
a person’s body; usually the arm is more affected than the leg.
• Spastic quadriplegia/quadriparesis―Spastic quadriplegia is the most
severe form of spastic CP and affects all four limbs, the trunk, and the
face. People with spastic quadriparesis usually cannot walk and often have
other developmental disabilities such as intellectual disability; seizures; or
problems with vision, hearing, or speech.
• Dyskinetic Cerebral Palsy (also includes
athetoid, choreoathetoid, and dystonic
cerebral palsies)
• People with dyskinetic CP have problems controlling the movement of
their hands, arms, feet, and legs, making it difficult to sit and walk.
• The movements are uncontrollable and can be slow and writhing or rapid
and jerky.
• A person with dyskinetic CP has muscle tone that can change (varying
from too tight to too loose) not only from day to day, but even during a
single day.
• Ataxic Cerebral Palsy
• People with ataxic CP have problems with balance and coordination.
• They might be unsteady when they walk. They might have a hard time
with quick movements or movements that need a lot of control, like
writing.
• They might have a hard time controlling their hands or arms when they
reach for something
• Mixed Cerebral Palsy
• Some people have symptoms of more than one type of CP.
• The most common type of mixed CP is spastic-dyskinetic CP.
Early signs
• The signs of CP vary greatly because there are
many different types and levels of disability.
The main sign that a child might have CP is a
delay reaching motor or movement
milestones (such as rolling over, sitting,
standing, or walking). Following are some
other signs of possible CP. It is important to
note that some children without CP also might
have some of these signs.
• In a Baby Younger Than 6 Months of Age
• His head lags when you pick him up while he’s lying
on his back
• He feels stiff
• He feels floppy
• When held cradled in your arms, he seems to
overextend his back and neck, constantly acting as if
he is pushing away from you
• When you pick him up, his legs get stiff and they
cross or scissor
• In a Baby Older Than 6 Months of Age
• She doesn’t roll over in either direction
• She cannot bring her hands together
• She has difficulty bringing her hands to her
mouth
• She reaches out with only one hand while
keeping the other fisted
• In a Baby Older Than 10 Months of Age
• He crawls in a lopsided manner, pushing off
with one hand and leg while dragging the
opposite hand and leg
• He scoots around on his buttocks or hops on
his knees, but does not crawl on all fours
Clinical features
• Delayed motor & mental milestones.
• Abnormal reflexes- persistence of primitive
reflexes( moro, asymmetric tonic neck,palmar
grasp)
• Failure to develop maturational
responses(landau,parachute,traction)
• Abnormal muscle tone.
• Abnormal movements
• Definite hand preference before 1 year.
• Skeletal deformities and joint contractures
(secondary to spastic muscles).
• Gait disturbances.
• Growth disturbances.
• Problems with
posture,balance,coordination,walking,speech,hearin
g,vision,swallowing,bowel & bladder etc.
• Are there any Neurological problems associated with
Cerebral Palsy?
• (1) Seizure Disorders (fits) 33% - 50%
• (2) Mental Retardation 50% - 70%
• (3) Learning Disorder 60% - 70%
• (4) Attention Deficit Hyperactive Disorders/ Behavioural
problems
• (5) Speech deficits/ shallow breath
• (6) Dysarthria - 50%
• (7) Feeding difficulties – swallowing problems, mouth
closures, tongue moments.
• (8) Sleep disturbances
Causes and Risk Factors of Cerebral
Palsy
• The brain damage that leads to CP can happen before birth,
during birth, within a month after birth, or during the first
years of a child’s life, while the brain is still developing.
• CP related to brain damage that occurred before or during
birth is called congenital CP. The majority of CP (85%–90%) is
congenital. In many cases, the specific cause is not known.
• A small percentage of CP is caused by brain damage that
occurs more than 28 days after birth. This is
called acquired CP, and usually is associated with an infection
(such as meningitis) or head injury
• Congenital CP
• CP related to brain damage that happened before or
during birth is called congenital CP. The majority of
CP (85%–90%) is congenital. In many cases, the
specific cause is not known.
• Some of the risk factors for congenital CP are:
• Low birthweight
• Premature birth
• Multiple births
• Assisted reproductive technology
(ART) infertility treatments
• Infections during pregnancy
• Jaundice and kernicterus
• Medical conditions of the mother
• Birth complications
Acquired CP
• Some causes of acquired CP are:
• Infection―Infections of the brain, for
example, meningitis or encephalitis during infancy.
• Injury―Injuries to the brain, for example, head injuries
caused by motor vehicle crashes or child abuse.
• Problem with blood flow to the brain―Cerebrovascular
accidents, for example, stroke or bleeding in the brain
associated with a blood clotting problem, blood vessels
that didn’t form properly, a heart defect that was
present at birth, or sickle cell disease.
• Risk Factors
• Some things increase the chance that a child will have CP. These are called
risk factors. It is important to remember that having a risk factor does not
mean that a child will have CP.
• Infection―Infections of the brain, for example, meningitis or encephalitis
during infancy.
• Injury―Injuries to the brain, for example, head injuries caused by motor
vehicle crashes or child abuse.
• Problem with blood flow to the brain―Cerebrovascular accidents, for
example, stroke or bleeding in the brain associated with a blood clotting
problem, blood vessels that didn’t form properly, a heart defect that was
present at birth, or sickle cell disease.
Screening and Diagnosis
• Developmental Monitoring
• Developmental monitoring (also called surveillance) means
tracking a child’s growth and development over time. If any
concerns about the child’s development are raised during
monitoring, then a developmental screening test should be
given as soon as possible
• Developmental Screening
• During developmental screening a short test is given to see if
the child has specific developmental delays, such as motor or
movement delays. If the results of the screening test are
cause for concern, then the doctor will make referrals for
developmental and medical evaluations.
Investigations
• Urine screening tests.
• Csf analysis
• Xray skull
• Xray spine
• TORCH screening.
• EMG/EEG
• USG cranium,CT brain,MRI
• Thyroid profile.
Treatments and Intervention Services
• There is no cure for CP, but treatment can
improve the lives of those who have the
condition. It is important to begin a treatment
program as early as possible.
• After a CP diagnosis is made, a team of health
professionals works with the child and family to
develop a plan to help the child reach his or her
full potential. Common treatments include
medicines; surgery; braces; and physical,
occupational, and speech therapy.

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Cerebral palsy

  • 2. History • William Little, a British surgeon, first identified Cerebral Palsy then called ‘Cerebral Paralysis’. • Sigmund Freud in 1897 suggested that difficult birth was not the only cause but rather only a symptom of other factors on the fetal development. Modern research has shown that 75% of cases were not due to birth asphyxia supporting Freud’s view even though through the 19th and 20th Centuries. Little’s view was the accepted explanation.
  • 3. What is Cerebral Palsy? • Cerebral palsy (CP) is a group of disorders that affect a person’s ability to move and maintain balance and posture. • CP is the most common motor disability in childhood. • Cerebral means having to do with the brain. Palsy means weakness or problems with using the muscles.
  • 4. Pathology • The following pathological changes can be seen- • Malformations: hypogenesis and dsygenesis • Infarction,focal necrosis and selective neuronal necrosis in brainstem or cortex. • Periventricular leukomalacia , necrosis and cystic degeneration of central white matter. • Degeneration and gliosis of hypothalamus , globus pallidus, substantia nigra, cerebral white matter and body of corpus callosum. • Status marmoratus in caudate nucleus, putamen and thalamus • Encephalitis/vasculitis.
  • 5. • We classify CP according to the main type of movement disorder involved. Depending on which areas of the brain are affected, one or more of the following movement disorders can occur: • Stiff muscles (spasticity) • Uncontrollable movements (dyskinesia) • Poor balance and coordination (ataxia)
  • 6. Types of Cerebral Palsy • Spastic Cerebral Palsy • The most common type of CP is spastic CP. Spastic CP affects about 80% of people with CP. • People with spastic CP have increased muscle tone. This means their muscles are stiff and, as a result, their movements can be awkward. Spastic CP usually is described by what parts of the body are affected:
  • 7. • Spastic diplegia/diparesis―In this type of CP, muscle stiffness is mainly in the legs, with the arms less affected or not affected at all. People with spastic diplegia might have difficulty walking because tight hip and leg muscles cause their legs to pull together, turn inward, and cross at the knees (also known as scissoring) • Spastic hemiplegia/hemiparesis―This type of CP affects only one side of a person’s body; usually the arm is more affected than the leg. • Spastic quadriplegia/quadriparesis―Spastic quadriplegia is the most severe form of spastic CP and affects all four limbs, the trunk, and the face. People with spastic quadriparesis usually cannot walk and often have other developmental disabilities such as intellectual disability; seizures; or problems with vision, hearing, or speech.
  • 8. • Dyskinetic Cerebral Palsy (also includes athetoid, choreoathetoid, and dystonic cerebral palsies) • People with dyskinetic CP have problems controlling the movement of their hands, arms, feet, and legs, making it difficult to sit and walk. • The movements are uncontrollable and can be slow and writhing or rapid and jerky. • A person with dyskinetic CP has muscle tone that can change (varying from too tight to too loose) not only from day to day, but even during a single day.
  • 9. • Ataxic Cerebral Palsy • People with ataxic CP have problems with balance and coordination. • They might be unsteady when they walk. They might have a hard time with quick movements or movements that need a lot of control, like writing. • They might have a hard time controlling their hands or arms when they reach for something • Mixed Cerebral Palsy • Some people have symptoms of more than one type of CP. • The most common type of mixed CP is spastic-dyskinetic CP.
  • 10. Early signs • The signs of CP vary greatly because there are many different types and levels of disability. The main sign that a child might have CP is a delay reaching motor or movement milestones (such as rolling over, sitting, standing, or walking). Following are some other signs of possible CP. It is important to note that some children without CP also might have some of these signs.
  • 11. • In a Baby Younger Than 6 Months of Age • His head lags when you pick him up while he’s lying on his back • He feels stiff • He feels floppy • When held cradled in your arms, he seems to overextend his back and neck, constantly acting as if he is pushing away from you • When you pick him up, his legs get stiff and they cross or scissor
  • 12. • In a Baby Older Than 6 Months of Age • She doesn’t roll over in either direction • She cannot bring her hands together • She has difficulty bringing her hands to her mouth • She reaches out with only one hand while keeping the other fisted
  • 13. • In a Baby Older Than 10 Months of Age • He crawls in a lopsided manner, pushing off with one hand and leg while dragging the opposite hand and leg • He scoots around on his buttocks or hops on his knees, but does not crawl on all fours
  • 14. Clinical features • Delayed motor & mental milestones. • Abnormal reflexes- persistence of primitive reflexes( moro, asymmetric tonic neck,palmar grasp) • Failure to develop maturational responses(landau,parachute,traction) • Abnormal muscle tone. • Abnormal movements
  • 15. • Definite hand preference before 1 year. • Skeletal deformities and joint contractures (secondary to spastic muscles). • Gait disturbances. • Growth disturbances. • Problems with posture,balance,coordination,walking,speech,hearin g,vision,swallowing,bowel & bladder etc.
  • 16. • Are there any Neurological problems associated with Cerebral Palsy? • (1) Seizure Disorders (fits) 33% - 50% • (2) Mental Retardation 50% - 70% • (3) Learning Disorder 60% - 70% • (4) Attention Deficit Hyperactive Disorders/ Behavioural problems • (5) Speech deficits/ shallow breath • (6) Dysarthria - 50% • (7) Feeding difficulties – swallowing problems, mouth closures, tongue moments. • (8) Sleep disturbances
  • 17. Causes and Risk Factors of Cerebral Palsy • The brain damage that leads to CP can happen before birth, during birth, within a month after birth, or during the first years of a child’s life, while the brain is still developing. • CP related to brain damage that occurred before or during birth is called congenital CP. The majority of CP (85%–90%) is congenital. In many cases, the specific cause is not known. • A small percentage of CP is caused by brain damage that occurs more than 28 days after birth. This is called acquired CP, and usually is associated with an infection (such as meningitis) or head injury
  • 18. • Congenital CP • CP related to brain damage that happened before or during birth is called congenital CP. The majority of CP (85%–90%) is congenital. In many cases, the specific cause is not known. • Some of the risk factors for congenital CP are:
  • 19. • Low birthweight • Premature birth • Multiple births • Assisted reproductive technology (ART) infertility treatments • Infections during pregnancy • Jaundice and kernicterus • Medical conditions of the mother • Birth complications
  • 20. Acquired CP • Some causes of acquired CP are: • Infection―Infections of the brain, for example, meningitis or encephalitis during infancy. • Injury―Injuries to the brain, for example, head injuries caused by motor vehicle crashes or child abuse. • Problem with blood flow to the brain―Cerebrovascular accidents, for example, stroke or bleeding in the brain associated with a blood clotting problem, blood vessels that didn’t form properly, a heart defect that was present at birth, or sickle cell disease.
  • 21. • Risk Factors • Some things increase the chance that a child will have CP. These are called risk factors. It is important to remember that having a risk factor does not mean that a child will have CP. • Infection―Infections of the brain, for example, meningitis or encephalitis during infancy. • Injury―Injuries to the brain, for example, head injuries caused by motor vehicle crashes or child abuse. • Problem with blood flow to the brain―Cerebrovascular accidents, for example, stroke or bleeding in the brain associated with a blood clotting problem, blood vessels that didn’t form properly, a heart defect that was present at birth, or sickle cell disease.
  • 22. Screening and Diagnosis • Developmental Monitoring • Developmental monitoring (also called surveillance) means tracking a child’s growth and development over time. If any concerns about the child’s development are raised during monitoring, then a developmental screening test should be given as soon as possible • Developmental Screening • During developmental screening a short test is given to see if the child has specific developmental delays, such as motor or movement delays. If the results of the screening test are cause for concern, then the doctor will make referrals for developmental and medical evaluations.
  • 23. Investigations • Urine screening tests. • Csf analysis • Xray skull • Xray spine • TORCH screening. • EMG/EEG • USG cranium,CT brain,MRI • Thyroid profile.
  • 24. Treatments and Intervention Services • There is no cure for CP, but treatment can improve the lives of those who have the condition. It is important to begin a treatment program as early as possible. • After a CP diagnosis is made, a team of health professionals works with the child and family to develop a plan to help the child reach his or her full potential. Common treatments include medicines; surgery; braces; and physical, occupational, and speech therapy.