1. Dr Anil
Dwivedi
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2. Outline
Early development with regulating Genes.
Primordial Heart circulation.
Partitioning of AV canal.
Partitioning of Primordial Atrium.
Changes in Sinus Venosus.
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3. Formation of RA & LA.
Partitioning of Primordial Ventricle &
BC.
Development of Cardiac Valves &
Conducting System.
Congenital Anomalies.
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4. DEVELOPMENT OF HEART
•CVS – 1st major system.
•why?
•From-
•splanchnic mesoderm
•paraxial & lat meso
•neural crest cells.
•Earliest sign – angioblastic cords.
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5. •18 days embryo.
•Dorsal view
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6. •Angioblastic cord in
cardiogenic area.
•Pericardial coelom.
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7. •4th week
•Effect of head fold on position of
Heart
•Septum transversum-central tendon
of Diaph.
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8. •20 days
•Dorsal view
•Two endocardial Heart tube & lat fold.
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9. •22 days
•Formation of pericardial cavity & fusing heart tubes
•Single Heart tube suspended by dorsal mesocardium
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10. •28 days
•Degeneration of central part of dorsal mesocardium
•Formation of Tr. Sinus
•Three layers of Heart wall.
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11. Genetic basis of growth of heart tube
6 HLH
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12. •Rt & Lt Heart tubes
•Cranial to caudal fusion
•Partial fusion of Sinus Venosus.
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13. Subdivisions of Heart tube & their fate
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14. 26 days
horns of sinus Venosus
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15. 15

16. Early Heart development & folding of primitive Heart tube
• The Bulbus cordis moves Inf Ant
& to the embryo Rt.
• The primitive ventricle moves to
Lf
• The prim Atrium & Sinus venosus
moves sup & post
• Sinus venosus is post to atrium.
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17. Early Heart development & folding of primitive Heart tube
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18. Circulation through primordial Heart
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19. Partitioning of Atrioventricular canal
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20. Partitioning of Atrioventricular canal
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21. Partition of the Atrioventricular canal

22. Partitioning of primordial Atrium
•4th week
•Septum primum
•Foramen primum
•Foramen secundum
•Septum secundum
•Foramen ovale
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23. Partitioning of primordial Atrium
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24. Partitioning of primordial Atrium
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25. Partitioning of primordial Atrium
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26. Partitioning of the primordial atrium
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27. Changes in the Sinus Venosus
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28. Changes in the Sinus Venosus
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29. Changes in the Sinuatrial Orifice
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30. Formation of the Right Atrium
Rt ½ primitive atrium
Sinus venosus
Rt ½ AV canal
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31. Formation of the Right Atrium
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32. Formation of the Left Atrium & PPV
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33. Partitioning of primordial Ventricle
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34. Partitioning of primordial Ventricle
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35. Partitioning of primordial Ventricle
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36. Partitioning of Bulbus Cordis & TA
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37. Developments of the Cardiac Valves
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38. Developments of the Cardiac Valves
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39. Developments of the Cardiac Valves
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40. Conducting system of the Heart
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41. Anomalies of the Heart
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42. Anomalies of the Heart
Anomalies of Position
• Dextrocardia
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43. Anomalies of the Heart
Anomalies of Position
Ectopia Cardis
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44. Atresia or Stenosis
• Aortic valve Stenosis
• Pulmonary valve Stenosis
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45. Defective formation of septa
ASD
• Patent oval foramen.
• F>M
• Probe patent foramen
incomplete adh of sep
sec.
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46. Defective formation of septa
ASD
• Ostium secundum ASD
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47. Defective formation of septa
ASD
• Endocardial cushion defect with Ostium primum ASD
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48. Defective formation of septa
ASD
• Sinus Venosus ASD
• Common Atrium.
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49. Defective formation of septa
VSD- most common CHD. -25%, M>F,
• Membranous – most common.
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50. Defective formation of septa
VSD
• Muscular(Swiss cheese)
• Single ventricle
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51. Persistent Truncus Arteriosus
Failure of-
• Truncal ridges
• aorticopulmonaryseptum
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52. Transposition of Great Arteries
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53. Tetralogy of Fallot
• Pulmonary Stenosis
• VSD
• Overriding of aorta
• Right ventricular
hypertrophy
Unequal div of TA
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54. SUMMARY
1. Formation and division of the heart tube;
2. Partitioning of Atrioventricular canal, atrium, ventricle, and
Truncus and Bulbus;
3. Congenital heart diseases.
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