Gro els

GroEL-GroES Chaperonin Complex PDB ID = 1AON

What are Chaperonins? ,[object Object],[object Object]

Where can chaperonins be found? ,[object Object],[object Object],[object Object]

Causes of Aggregations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Consequences of Aggregation ,[object Object],[object Object]

Chaperonins counteract non-native protein aggregation ,[object Object]

Experimental Details ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GroEL-GroES Architecture E = E. coli ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GroEL-GroES Architecture Equatorial = pink Intermediate = yellow Apical = blue Polar + Charge = blue Hydrophobic = yellow Backbone = white Solvent-Excluded surfaces = gray

GroEL-GroES Sequences 8337 Residues 58884 Atoms Equatorial = orange Intermediate = purple Apical = cyan

GroES Domain ,[object Object],[object Object]

GroEL Domains ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Conformational Change of Cavity

How do chaperonins work? ,[object Object],[object Object]

Overall Chaperonins Protein Folding Reaction ,[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

1AON chain A = red 1A6E chain A = yellow 1A6D chain A = green 1A6E Thermosome - Mg-ADP-Alf3 Complex 1A6D Thermosome From T. Acidophilum Ca 4.15A 87 atoms Ca 4.58 A 87 atoms

Structural Neighbors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ALDEHYDE DEHYDROGENASE (CHAIN A) PDB ID: 1BPW

Gro els

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