Diaporama présenté lors des dernières journées SFEROV de Toulouse (26 octobre 2014). Utilisation de l'OCT dans le diagnostic des affections de la cornée chez le chien et le chat.
Accelerated cxl for the treatment of infectious keratitisFrank FAMOSE
This document summarizes a study on using accelerated corneal collagen cross-linking (CXL) to treat infectious keratitis in dogs and cats. The study used an accelerated CXL protocol involving 30 minutes of UVA exposure at 30 mW/cm2 (5.4 J/cm2 total dose) after corneal soaking with riboflavin drops. The results showed no adverse reactions and complete resolution of corneal infiltration and vascularization in 8/8 dogs and 10/10 cats by one month post-op, with minimal corneal scarring. The accelerated CXL provided a single, highly successful treatment that preserved vision and did not require specialized technical skills or long procedure times.
Cxl for the treatment of bullous keratopathy in dogsFrank FAMOSE
This document discusses bullous keratopathy (BK), a condition causing corneal edema, ulceration, and vision loss. It describes current treatments for BK like topical drugs and corneal grafts, which often have poor results. The document then reviews how corneal collagen cross-linking (CXL) has been used in humans to treat BK by strengthening the cornea and reducing edema, with over 30 publications since 2007 reporting temporary relief and improved vision. Finally, it outlines two veterinary case studies that found CXL resolved ulceration in dogs with BK within a week, though edema returned over six months.
This study evaluated the use of accelerated collagen cross-linking (CXL) after iontophoresis for the treatment of melting keratitis in 6 cats. Iontophoresis uses a constant electric current to enhance penetration of ionized substances like riboflavin through the cornea. The study found that using iontophoresis to apply riboflavin before accelerated CXL reduced clinical scores and pain levels in the cats and led to complete epithelial healing and resolution of corneal melting within an average of 40 days, with results similar to conventional riboflavin instillation but in a shorter procedure time and without adverse effects. The authors conclude that iontophoresis is an effective way to enhance riboflavin penetration for C
This document provides an overview of corneal collagen cross-linking (CXL) for veterinarians. It discusses the basic principles of CXL including riboflavin activation and its tissular effects. Guidelines are provided for riboflavin administration through both epi-off and epi-on methods as well as iontophoresis. The document also reviews UVA irradiation parameters and protocols for different corneal conditions. Expected outcomes from CXL are summarized for dogs and cats based on published studies. Financial considerations including cost analysis, pricing models and calculating the treatment "dead point" are also covered.
Présentation proposée aux journées d'actualités thérapeutique de la SFEROV en octobre 2014. Intérêt de la Iontophorèse pour l'imprégnation de la cornée par la riboflavine avant cross-linking du collagène cornéen.
Présentation faite au Xème congrés international sur le cross-linking du collagène cornéen (Zurich 5-6 décembre 2014).
Lecture given during the Xth international congress of corneal collagen cross-linking, (Zurich 5-6 th december 2014)
Evaluation of accelerated collagen cross-linking for the treatment of melting...Frank FAMOSE
Accelerated collagen cross-linking was used to treat melting keratitis in 8 dogs. The following results were observed:
1) Pain improvement was seen in all cases within 3 days after treatment.
2) Epithelial healing was observed within 15 days for all cases.
3) Disappearance of cellular infiltration was observed in all cases by day 7.
4) Corneal vascularization disappeared in 4 cases and was reduced in 4 cases by 1 month.
5) At 1 month, all eyes had visual function despite variable corneal scarring. No recurrent infections occurred.
The study suggests that accelerated collagen cross-linking is a valuable treatment for melting keratitis in dogs.
Newsletter n°1 de juin 2013. Actualités en ophtalmologie vétérinaire.
Les lentilles de collagène résorbables.
Cas clinique : cécité brutale chez un chat
This document evaluates the use of accelerated collagen cross-linking (CXL) to treat corneal melting in 8 dogs and 10 cats. It finds that accelerated CXL using an exposure time of 3 minutes at 30 mW/cm2 was effective in reducing corneal infiltration and vascularization in all treated animals. No adverse reactions were observed. The accelerated protocol allows for a shorter anesthesia time compared to the standard 30-minute CXL protocol, while delivering the same total energy to the cornea.
35 normal and 40 pathological canine eyes were studied using anterior segment optical coherence tomography (AS-OCT). AS-OCT provided highly accurate imaging and measurement of corneal diseases, allowing quantitative and qualitative evaluation. AS-OCT was somewhat useful for evaluating lens and iris conditions but provided limited additional information compared to other techniques for glaucoma evaluation. The main advantage of AS-OCT is its non-contact high resolution imaging of the cornea without need for ocular contact.
Diaporama présenté lors des dernières journées SFEROV de Toulouse (26 octobre 2014). Utilisation de l'OCT dans le diagnostic des affections de la cornée chez le chien et le chat.
Accelerated cxl for the treatment of infectious keratitisFrank FAMOSE
This document summarizes a study on using accelerated corneal collagen cross-linking (CXL) to treat infectious keratitis in dogs and cats. The study used an accelerated CXL protocol involving 30 minutes of UVA exposure at 30 mW/cm2 (5.4 J/cm2 total dose) after corneal soaking with riboflavin drops. The results showed no adverse reactions and complete resolution of corneal infiltration and vascularization in 8/8 dogs and 10/10 cats by one month post-op, with minimal corneal scarring. The accelerated CXL provided a single, highly successful treatment that preserved vision and did not require specialized technical skills or long procedure times.
Cxl for the treatment of bullous keratopathy in dogsFrank FAMOSE
This document discusses bullous keratopathy (BK), a condition causing corneal edema, ulceration, and vision loss. It describes current treatments for BK like topical drugs and corneal grafts, which often have poor results. The document then reviews how corneal collagen cross-linking (CXL) has been used in humans to treat BK by strengthening the cornea and reducing edema, with over 30 publications since 2007 reporting temporary relief and improved vision. Finally, it outlines two veterinary case studies that found CXL resolved ulceration in dogs with BK within a week, though edema returned over six months.
This study evaluated the use of accelerated collagen cross-linking (CXL) after iontophoresis for the treatment of melting keratitis in 6 cats. Iontophoresis uses a constant electric current to enhance penetration of ionized substances like riboflavin through the cornea. The study found that using iontophoresis to apply riboflavin before accelerated CXL reduced clinical scores and pain levels in the cats and led to complete epithelial healing and resolution of corneal melting within an average of 40 days, with results similar to conventional riboflavin instillation but in a shorter procedure time and without adverse effects. The authors conclude that iontophoresis is an effective way to enhance riboflavin penetration for C
This document provides an overview of corneal collagen cross-linking (CXL) for veterinarians. It discusses the basic principles of CXL including riboflavin activation and its tissular effects. Guidelines are provided for riboflavin administration through both epi-off and epi-on methods as well as iontophoresis. The document also reviews UVA irradiation parameters and protocols for different corneal conditions. Expected outcomes from CXL are summarized for dogs and cats based on published studies. Financial considerations including cost analysis, pricing models and calculating the treatment "dead point" are also covered.
Présentation proposée aux journées d'actualités thérapeutique de la SFEROV en octobre 2014. Intérêt de la Iontophorèse pour l'imprégnation de la cornée par la riboflavine avant cross-linking du collagène cornéen.
Présentation faite au Xème congrés international sur le cross-linking du collagène cornéen (Zurich 5-6 décembre 2014).
Lecture given during the Xth international congress of corneal collagen cross-linking, (Zurich 5-6 th december 2014)
Evaluation of accelerated collagen cross-linking for the treatment of melting...Frank FAMOSE
Accelerated collagen cross-linking was used to treat melting keratitis in 8 dogs. The following results were observed:
1) Pain improvement was seen in all cases within 3 days after treatment.
2) Epithelial healing was observed within 15 days for all cases.
3) Disappearance of cellular infiltration was observed in all cases by day 7.
4) Corneal vascularization disappeared in 4 cases and was reduced in 4 cases by 1 month.
5) At 1 month, all eyes had visual function despite variable corneal scarring. No recurrent infections occurred.
The study suggests that accelerated collagen cross-linking is a valuable treatment for melting keratitis in dogs.
Newsletter n°1 de juin 2013. Actualités en ophtalmologie vétérinaire.
Les lentilles de collagène résorbables.
Cas clinique : cécité brutale chez un chat
This document evaluates the use of accelerated collagen cross-linking (CXL) to treat corneal melting in 8 dogs and 10 cats. It finds that accelerated CXL using an exposure time of 3 minutes at 30 mW/cm2 was effective in reducing corneal infiltration and vascularization in all treated animals. No adverse reactions were observed. The accelerated protocol allows for a shorter anesthesia time compared to the standard 30-minute CXL protocol, while delivering the same total energy to the cornea.
35 normal and 40 pathological canine eyes were studied using anterior segment optical coherence tomography (AS-OCT). AS-OCT provided highly accurate imaging and measurement of corneal diseases, allowing quantitative and qualitative evaluation. AS-OCT was somewhat useful for evaluating lens and iris conditions but provided limited additional information compared to other techniques for glaucoma evaluation. The main advantage of AS-OCT is its non-contact high resolution imaging of the cornea without need for ocular contact.