Viruses like HIV and influenza have demonstrated the ability to cross species boundaries from animals to humans. This presentation defines zoonotic transmission as the movement of viruses from animals to people through direct contact, consumption of contaminated animal products, or interaction in shared environments. Examples provided include SARS, Ebola, swine flu, rabies, and avian influenza. Factors such as human encroachment, changes in animal populations, and global travel can influence this cross-species transmission and the emergence of new zoonotic diseases. Effective prevention relies on surveillance, biosecurity measures, and a One Health approach across human, animal, and environmental sectors.