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This study was carried out to evaluate the effect of ethanolic leaf extract of Sida acuta on the micro-anatomy of the liver and some biochemical parameters in adult Wistar rats. Thirty rats weighing between 140-180g were assigned to three groups (A, B and C) with ten animals each. Group A served as the control while groups B and C served as the experimental groups and received 100mg/kgbw and 200mg/kgbw of the extract respectively for fourteen days. All the animals were sacrificed after fourteen days. Blood was collected by cardiac puncture for biochemical analysis of serum liver enzymes s The liver was removed, preserved and processed for paraffin sections and hematoxylin and eosin (H&E) staining. The animals in the control group showed normal histological and biochemical parameters. Conversely, animals that received 100mg/kgbw of the extract showed slight difference in their hepatic cyto-architecture while animals that were administered with 200mg/kgbw of the extract revealed distorted morphological feature showing shrunken sinusoid and dilation of the central vein suggesting that the extract has adverse effect on the morphology of the liver. Results of the serum liver enzymes of animals treated with 100mg/kgbw and 200mg/kg revealed significantly decreased values of AST, ALP and ALT (P <0.05) relative to the control. From the result of this experiment, it is concluded that administration of ethanolic extract of Sida acuta leaves may be toxic to Wistar rats at the doses administered.
The evaluation of the effect of Sida acuta leaf extract on the microanatomy a...
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IOSR Journals
This paper aims at identifying an effective and appropriate method of calculating the cost of transporting goods from several supply centers to several demand centers out of many available methods. Transportation algorithms of North-West corner method (NWCM), Least Cost Method (LCM), Vogel’s Approximation Method (VAM) and Optimality Test were carried out to estimate the cost of transporting produced newspaper from production center to ware-houses using Statistical software called TORA. The results revealed that: NWCM = 36,689,050.00, LCM = 55,250,034.00, VAM = 29,097,700.00 and Optimal solution = 19,566,332.00. It was discovered that Vogel’s Approximation method gives the transportation cost that closer to optimal solution. Also, the study revealed that a production center should be created at northern part of Nigeria to replace the dummy supply center used in the analysis, so as to make production capacity equal to requirement.
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IOSR Journals
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The evaluation of the effect of Sida acuta leaf extract on the microanatomy a...
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Power972003
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