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ANTI-ARRHYTHMIC DRUGS Ma. Janetth B. Serrano, M.D.,DPBA
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ANTI – ARRHYTHMIC  DRUGS
ELECTRO-PHYSIOLOGY  OF  NORMAL  CARDIAC  RHYTHM ,[object Object],AV node ATRIA His-Purkinje System VENTRICLES ANTI – ARRHYTHMIC  DRUGS
IONIC BASIS OF MEMBRANE ELECTRICAL ACTIVITY ,[object Object],[object Object],[object Object],ANTI – ARRHYTHMIC  DRUGS
PHASES OF ACTION POTENTIAL ,[object Object],[object Object],[object Object],[object Object],Phase 1 >Limited depolarization >Inactivation of  fast  Na+ channels -> Na+  ion conc equalizes >↑ K+ efflux & Cl- influx Phase 2 >Plateau Stage >Cell less permeable to Na+ >Ca++ influx through slow Ca++ channels >K+ begins to leave cell Phase 3 >Rapid repolarization >Na+ gates closed >K+ efflux >Inactivation of slow Ca++ channels Phase 4 >Resting Membrane Potential >High K+ efflux >Ca++ influx ANTI – ARRHYTHMIC  DRUGS
MECHANISMS OF ARRHYTHMIA ,[object Object],[object Object],ARRHYTHMIAS result from: ,[object Object],[object Object],[object Object],[object Object],ANTI – ARRHYTHMIC  DRUGS
FACTORS PRECIPITATING CARDIAC ARRHYTHMIAS: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ARRHYTHMIAS: ANTI – ARRHYTHMIC  DRUGS
CLASS I: Sodium Channel Blocking Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],CLASS II: BETA-BLOCKING AGENTS ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],CLASS III: POTASSIUM CHANNEL BLOCKERS ANTI – ARRHYTHMIC  DRUGS
CLASS IV: CALCIUM CHANNEL BLOCKERS ,[object Object],[object Object],[object Object],[object Object],[object Object],ANTI – ARRHYTHMIC  DRUGS
Miscellaneous: ,[object Object],[object Object],[object Object],[object Object],ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: Sodium Channel Blocking Drugs CLASS IA:  QUINIDINE ANTI – ARRHYTHMIC  DRUGS
CLASS I: SODIUM CHANNEL BLOCKERS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS IA: QUINIDINE ANTI – ARRHYTHMIC  DRUGS
CLASS I: SODIUM CHANNEL BLOCKERS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS IA: QUINIDINE ANTI – ARRHYTHMIC  DRUGS
CLASS I: SODIUM CHANNEL BLOCKERS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS IA: QUINIDINE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: PROCAINAMIDE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: PROCAINAMIDE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: PROCAINAMIDE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: PROCAINAMIDE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: DISOPYRAMIDE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: DISOPYRAMIDE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: AMIODARONE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: AMIODARONE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: AMIODARONE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IA: AMIODARONE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IB: LIDOCAINE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IB: LIDOCAINE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IB: LIDOCAINE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IB: TOCAINIDE & MEXILETENE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IB: PHENYTOIN ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IC: FLECAINIDE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IC: PROPAFENONE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS I: SODIUM CHANNEL BLOCKERS CLASS IC: MORICIZINE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS II: BETA ADRENOCEPTOR BLOCKERS ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS II: BETA ADRENOCEPTOR BLOCKERS ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],CLASS II: BETA ADRENOCEPTOR BLOCKERS Specific agents: ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS III: POTASSIUM CHANNEL BLOCKERS ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS III: POTASSIUM CHANNEL BLOCKERS BRETYLIUM ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS III: POTASSIUM CHANNEL BLOCKERS BRETYLIUM ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS III: POTASSIUM CHANNEL BLOCKERS SOTALOL ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS III: POTASSIUM CHANNEL BLOCKERS IBUTILIDE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],CLASS III: POTASSIUM CHANNEL BLOCKERS DOFETILIDE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],CLASS IV: CALCIUM CHANNEL BLOCKERS VERAPAMIL ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS IV: CALCIUM CHANNEL BLOCKERS VERAPAMIL ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],CLASS IV: CALCIUM CHANNEL BLOCKERS DILTIAZEM & BEPRIDIL ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],MISCELLANEOUS ANTIARRHYTHMIC AGENTS: DIGITALIS ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],MISCELLANEOUS ANTIARRHYTHMIC AGENTS: ADENOSINE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],MISCELLANEOUS ANTIARRHYTHMIC AGENTS: ADENOSINE ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],MISCELLANEOUS ANTIARRHYTHMIC AGENTS: MAGNESIUM ANTI – ARRHYTHMIC  DRUGS
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ANTI – ARRHYTHMIC  DRUGS MISCELLANEOUS ANTIARRHYTHMIC AGENTS: POTASSIUM

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Editd anti arrhythmic

  • 1. ANTI-ARRHYTHMIC DRUGS Ma. Janetth B. Serrano, M.D.,DPBA
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Notes de l'éditeur

  1. S,