Modern Nanostructures for Diagnosis and Treatment

1. Modern Nanostructures for Diagnosis and Treatment

3. Present at target in sufficient quantity

4. No loss of efficacyWhy work with nanoscale drug delivery systems?

6. Large Particles (>200 nm) are quickly captured and excreted

7. Particles between 70 and 200 nm show longest circulation time

8. Particles between 10 and 70 nm penetrate capillary vesselsActive Targeting Bioactive substances can be triggered to release drugs at target area. Long circulation time- Particle size

10. Non-ionized, lipophilic materials

11. Epithelial junctions in skin

12. Gene transfection

14. This is the motivation for a number of the structuresManaging Distribution

15. Nanocapsules Nanotubes Nanogels Dendrimers Nanoshells Nanocomposites Nanofibers Other Structures Nanostructures

17. Synthesized with polymers

18. Tendency to aggregate and fuseNanostructures- Liposomes

19. Liposome Micelles in Practice Effect of the hydrophobic molecule on the morphology of the micelles. (a) 10% wt. F127, (b) 10% wt. F127 with 0.2% wt. Haloperidol.

21. Extended stability

22. Low Toxicity

23. Limited methods for surface coatingNanostructures-Nanogels

26. Industrial - fuel cells, filtration Nanofibers

28. High pressure