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Alan Schilowitz , Andy Riley, Dalia Yablon, Mark Disko ExxonMobil Research and Engineering Co. Corporate Strategic Research Laboratory Annandale, New Jersey Ultra-Sensitive Microsensors for Chemical Analysis
Why Microsensors ? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How Many Cantilevers Can Fit on the Head of a Pin ? 2 mm ,[object Object],[object Object],[object Object]
Micro-Cantilevers Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Laser PSD Focusing Lens
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Analysis in Dynamic Mode 0 2000 4000 6000 8000 10000 12000 Frequency (Hz) Amplitude Air Increasing Viscosity
Cantilevers Respond to Viscous Damping High Q Low Q Increasing Viscosity ,[object Object],[object Object],[object Object]
Chemical Analysis in Static Mode ,[object Object],Selective adsorbant  on one side only Untreated Cantilever Gold Coated Cantilever Detects Mercaptans Mercaptan Injection ,[object Object],[object Object]
Functionalized Cantilever Arrays for Aromatics Detection Self-Assembled Monolayers Impart Chemical Selectivity to Highly Sensitive Cantilever Transducers Self-Assembled Monolayer  Candidates: SH Benzyl Mercaptan SH Naphthalenethiol SH OH Mercaptohexanol SH (  ) 6 Octadecanethiol
Cantilever Response To Aromatic Vapor ,[object Object],[object Object],S OH S S (  ) 6 S toluene xylene toluene xylene d. ODT - octadecanethiol c. MH - mercaptohexanol b. NT - naphthalenethiol a. BM – benzyl mercaptan toluene xylene toluene xylene
Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Medical Applications Light traces are before exposure to e-coli Dark traces are after exposure B. Illic et.al., Appl. Phys. Lett.  77 (3),  450 (2000) E-Coli Sensor ,[object Object],[object Object],W. Guanghua et.al., Nature Biotechnology  19 ,  856 (2001) Prostate Specific Antigen (PSA) Sensor
References -  Medical Applications Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA  Zhang, J.; Lang, HP.; Huber, F.; Bietsch, A.; Grange, W.; Certa, U.;  McKendry, R . ; Guntherodt, HJ.; Hegner, M. & Gerber, Ch.   Nature Nanotechnology ,  1 , 214-220 (2006).   Novel electrical detection of label-free disease marker proteins using piezoresistive self-sensing micro-cantilevers Wee KW, Kang GY, Park J, Kang JY, Yoon DS, Park JH, Kim TS Biosens Bioelectron  2005 Apr 15;20(10):1932-8 Array of Nano­Cantilevers as a Bio­Assay for Cancer Diagnosis Klein, K.M.; Jiantao Zheng; Gewirtz, A.; Sarma, D.S.; Rajalakshmi, S.; Sitaraman, K. Electronic Components and Technology Conference, 2005. Proceedings. 55th Volume , Issue , 31 May-3 June 2005 Page(s): 583 - 587 A Review of Microcantilevers for Sensing Applications Vashist, S.K.,  June 2007 www.azonano.com/details.asp?ArticleID=1927

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Ultra-Sensitive Microsensors for Chemical Analysis, pumpsandpipesmdhc

  • 1. Alan Schilowitz , Andy Riley, Dalia Yablon, Mark Disko ExxonMobil Research and Engineering Co. Corporate Strategic Research Laboratory Annandale, New Jersey Ultra-Sensitive Microsensors for Chemical Analysis
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. Functionalized Cantilever Arrays for Aromatics Detection Self-Assembled Monolayers Impart Chemical Selectivity to Highly Sensitive Cantilever Transducers Self-Assembled Monolayer Candidates: SH Benzyl Mercaptan SH Naphthalenethiol SH OH Mercaptohexanol SH ( ) 6 Octadecanethiol
  • 9.
  • 10.
  • 11.
  • 12. References - Medical Applications Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA Zhang, J.; Lang, HP.; Huber, F.; Bietsch, A.; Grange, W.; Certa, U.; McKendry, R . ; Guntherodt, HJ.; Hegner, M. & Gerber, Ch.  Nature Nanotechnology , 1 , 214-220 (2006). Novel electrical detection of label-free disease marker proteins using piezoresistive self-sensing micro-cantilevers Wee KW, Kang GY, Park J, Kang JY, Yoon DS, Park JH, Kim TS Biosens Bioelectron 2005 Apr 15;20(10):1932-8 Array of Nano­Cantilevers as a Bio­Assay for Cancer Diagnosis Klein, K.M.; Jiantao Zheng; Gewirtz, A.; Sarma, D.S.; Rajalakshmi, S.; Sitaraman, K. Electronic Components and Technology Conference, 2005. Proceedings. 55th Volume , Issue , 31 May-3 June 2005 Page(s): 583 - 587 A Review of Microcantilevers for Sensing Applications Vashist, S.K., June 2007 www.azonano.com/details.asp?ArticleID=1927