Substance abuse is a major preventable health issue in the United States, responsible for more deaths, illnesses, and disabilities than any other condition. Substance abuse has widespread social consequences and affects all groups in society regardless of age or economic status. The most commonly used substances are alcohol, tobacco, and illicit drugs like marijuana, cocaine, heroin, and prescription medications. Prevention and treatment of substance abuse disorders is a complex issue with no single solution, requiring efforts across multiple levels including education, social support, and tailored treatment programs.