Maurizio Vecchione represents Global Good to deliver the presentation on Reverse Innovation in Global Health and Global Development to drive catalytic invention, with the power to move the bottom Billion into the Sustainable Development Goals. Case studies include AI-based Microscopy, Photonic Fence for vector control in health and agriculture eradication, High Sensitivity Point of Care Diagnostics for disease eradication.

1. Invention saving lives

2. “What unifies all forms of creative
capitalism is that they are market-driven
efforts to bring solutions we take for
granted to people who can't get them.”
— Bill Gates
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3. No one has a monopoly on innovation.
Great ideas can come from
rich and poor areas alike
‒ and provide benefit to both.
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• Inventing for challenging physical environments can result in more robust
products for all environments
• Usability enables operation by greater number of health workers
• Partner distribution agreements leverage market forces to support scalability and
sustainability
Reverse Innovation
Solutions to developing-world needs can deliver value to all economies worldwide

5. Untapped potential for invention
Booz & Company’s
“Global Innovation 1000”
G-FINDER’s
34 Neglected Diseases
$600B
TOTAL R&D
Healthcare
$130B
Computer &
Electronics
$170B
$3B
TOTAL R&D
HIV/TB/Malaria
$2.1B

6. INVENTING FOR THE
BOTTOM BILLION

7. Hundreds of thousands
of preventable deaths not prevented
20% of vaccines spoil before delivery

12. HIGH-TECH, LOW-COST
DIAGNOSTICS

14. Like a Pregnancy Test, But More Powerful
• As clinically sensitive as PCR
• Asymptomatic malaria
• TB detection from urine
• Quantitative results
• Made and distributedby the
suppliersof current test strips,
at similar cost

15. PREDICTIVE
MODELING FOR
DISEASE
ERADICATION

16. Guiding the Polio Campaign in Nigeria
Upfill-Brown et al., BMC Medicine 2014

17. Partnering for Invention
Government, Multilateral
NGO and Commercial
Sectors
Late stage
Execution
Invention Technology
Development
Product
Development
Piloting
Clinical
and
Field
trials
Manufacturing
Capacity
Sales
Marketing
Distribution
Early stage
High risk

18. AI Based Microscopy
“Smart microscope” makes the gold-standard of malaria diagnosis accessible to all
• Trained to recognize malaria parasites
• Machine learning was based on millions of
actual sample slides
• Can diagnose malaria as accurately as the
best trained expert microscopist
• Also being trained to detect other
pathologies
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19. Improving Oxygen
Delivery to Infants
• O2 is key therapy for pediatric pneumonia, the
leading cause of death in children in the poorest 75
countries
• Oxygen delivery is often interrupted due to lack of
power
• We invented new systems that can double duration
of oxygen delivery, bridging most power failures
• To test new designs, we generated scale models
based on actual face and respiratory cavities CT
scans for thousands of children
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20. THANK YOU