for cancer

1. Metabolic reprogramming
in cancer
Presenter:
Anupama Modi
Supervisor:
Dr. Mithu Banerjee

2. Introduction
⮚What is cancer?
⮚Hallmarks of cancer
⮚What is metabolic reprogramming of cancer?
⮚Metabolic reprogramming in cancer cell compared with normal cell

3. Metabolic reprogramming in progression of
cancer
⮚Proliferation:
⮚ Inhibition of apoptosis:
⮚Angiogenesis:
⮚Metastasis:
⮚Chemoresistance:

4. Elevation of Glycolysis
⮚Warburg-Effect
⮚Glucose metabolism in normal cell
⮚Glucose metabolism in cancer cell compare with normal cell
⮚Aerobic glycolysis in cancer cell
⮚Lactate as inducer of cancer
⮚Master glycolysis inducing oncogenes
⮚p53 as a regulator of glycolysis
⮚Diagnosis of cancer through PET

5. Glutaminolysis
⮚What is glutaminolysis?
⮚How it is differ from normal cell?
⮚Regulation of glutaminolysis in cancer

6. Pentose phosphate pathway
⮚What is pentose phosphate pathway (PPP)?
⮚PPP in cancer
⮚PPP in drug resistance

7. Mitochondrial biogenesis
⮚Role of mitochondria in cancer
⮚Regulation of mitochondria biogenesis in cancer

8. Lipid synthesis
⮚Role of lipid synthesis in cancer
⮚Regulation of lipid synthesis in cancer
⮚Role of cholesterol in cancer
⮚Obesity increases the risk of cancer

9. Fatty acid oxidation (FAO)
• FAO generates more energy in cancer
• Regulation of FAO in cancer

10. Summary of key changes

11. Cancer metabolism and diagnostic
imaging

12. PET
⮚PET in combination with CT- Diagnosis of cancer
⮚Metabolites reprogrammed: Used as tracer in diagnosis of cancer
⮚18F-fluoro-2-deoxyglucose (FDG)
⮚11C Cholin
⮚3'-deoxy-3'-18F-fluorothymidine
⮚68Ga-DOTATOC
⮚16-α-18F-fluoro-17β-estradiol

13. MRI and MRSI
⮚MRI in combination with MSRI- clinical oncology diagnostics
⮚1H choline-containing metabolites
⮚choline/N-acetyl aspartate
⮚Choline/creatinine
⮚13C pyruvate-to-13C lactate flux

14. Therapeutic implication

16. Thank You