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Preventing alcohol misuse in young people:
implementation, feasibility and acceptability of a
primary-school-based intervention with a family
component - the Kids, Adults Together (KAT)
Programme
The KAT research team
Jeremy Segrott (PI)
Heather Rothwell
Simon Murphy
Gillian Hewitt
Matt Hickman
Rebecca Playle
Chao Huang
Hayley Reed
Laurence Moore
Cheryl Briscombe
Outline of presentation







Background and objectives of the study
Methods
Intervention
Outcomes
Results
Conclusions
Alcohol consumption during childhood
and adolescence
Harmful consequences in the short term [1, 2]
– Accidental injury and death
– Sexually transmitted disease
– Delinquency and violence
– Mental illness
– Impaired academic performance
Increased risk of long-term dependence and
physical, mental and social harm [3]

http://news.bbcimg.co.uk/media/images/49617000/jpg/_49617521_underage_drinking-spl.jpg
What is known about preventing
alcohol misuse (1)?

 Need for more evidence of effectiveness of
specific programmes targeting children [5]
 Some evidence programmes are more effective
when children have not started drinking [6,7]
 Schools are important locations for universal
prevention programmes
 maximise reach [8-10]
 deliver health curricula
 school environment/ethos important
What is known about preventing
alcohol misuse (2)?
 More promising programmes have [11-16]
– A clear theoretical basis
– Interactive delivery style
– Community (including parent/family) involvement

 Social Development theory [17] explains
importance of interactive delivery and
community involvement
Social Development Model

Perceived
opportunities
for prosocial
interaction

Involvement
in prosocial
interaction

Perceived
rewards
for prosocial
interaction

Attachment
to prosocial
others

prosocial = positive v antisocial

Prosocial
values &
behaviour
Parents’ role in preventing alcohol misuse
 Key influence on pre-adolescent children [18-20]
– Modelling norms and examples
– Controlling access to alcohol
– Broader family relationships and communication

 When involved in programmes:
– exposed to the same messages as children
– can reinforce them through actions and attitudes
Programmes, primary schools, parents
and prevention
 Few prevention programmes have been
implemented in primary schools with preadolescent children[30]
 Most studies have been conducted outside
the UK [5]
 Many prevention programmes and studies
have either not aimed to involve parents or
have not met recruitment targets for parent
participation [24-28]
The Kids, Adults Together (KAT) programme
Comprises three components

–
–
–
–

Classroom activities on key health issues about alcohol
(manual + resources for teachers)
Around 20 hours contact time
Designed to link into PSE and other curriculum areas
A way of addressing other school aims – e.g. parental
involvement

 Building to a family event at which pupils present their work
 Goody bag and DVD for parents and pupils to watch together
The Kids, Adults Together (KAT) programme
 For 9-11 year-old children at primary schools
 Intended effects in reducing alcohol misuse depend
on
–
–

parental participation
promotion of family communication

 Its message is “Not too much, not too soon”
 At two pilot schools in 2010 [29] KAT:
– engaged 40-50 parents at each of 2 events
– was acceptable to children, parents and teachers
KAT’s logic model

Perceived
opportunities
for prosocial
interaction
Classroom
preparation,
fun evening,
DVD, leaflets

Involvement
in prosocial
interaction
Interactive
learning in
classroom
and fun evening,
making smoothies,
watching DVD,
family
communication

Perceived
rewards
for prosocial
interaction
Teachers’
and parents’
recognition
and
appreciation
of children’s work

Attachment
to prosocial
others
Communication
fosters
parent-child
bond

Prosocial
values &
behaviour
Exploratory trial
 Design: Exploratory randomised controlled trial
 Aim: assess the value and feasibility of conducting
an effectiveness trial of KAT
 Setting: City in South Wales, UK
 Participants:
– Primary schools of varied size and sociodemographic profile (FSM entitlement rates)
– pupils in Years 5 and 6 (aged 9-11 years)
– parents/carers
– school staff
Exploratory trial
Intervention group (n=5)
 3 schools ran the KAT programme in addition to any existing
alcohol-related lessons / activities
 2 schools withdrew without implementing KAT
Control group (n=4)
 Schools continued with existing lessons / activities
Both groups
 Baseline + short term follow-up pupil questionnaires
 Telephone interviews conducted with parents
 Process evaluation conducted to look at implementation
Outcomes






quality of programme implementation
programme acceptability
recruitment and retention of research participants
acceptability and feasibility of research processes
Acceptability and feasibility of providing
demographic data and answering questions about
alcohol consumption and family communication
 estimates of potential effect and sample sizes
Findings: Implementation fidelity
 Good overall

 ... but some elements better than others
 Interactive methods well implemented
 ... But not all teachers promoted a healthy
approach to alcohol use.
 Hard to involve all staff in training/meetings
Findings: Programme acceptability
 Teachers liked KAT – good fit with curriculum
 Children liked interactive work & family involvement
 Parents liked the family events – informative, nonjudgemental, non-stigmatising
 “Not too much, not too soon” message was well
received and understood

 Wider implementation: A potential pathway was
identified but no funding was available
Findings: potential programme effects
Intervention effect on family communication:
(intermediate outcome):
– Mixed evidence from process evaluation
interviews with parents
– Statistical analysis of children’s questionnaire data
showed no evidence of an effect
– Some issues with reliability of questionnaire
responses
Findings: reach
70.0

Did any of your family go to the KAT event?

60.0

50.0

40.0
School 3
School 4
30.0

School 6

20.0

10.0

0.0
FSM (%)

Yes (%)

No (%)

Family members attending (n)
Findings: reach
Did any of your family go to the KAT event? Responses from 141
pupils who provided data on Family Affluence Score (FAS)

Family members attending (total n)

High FAS (n=83)

No (%)

Medium FAS (n=49)
Low FAS (n=9)

Yes (%)

0

10

20

30

40

50

60

70

80

90
Findings: Feasibility and acceptability
of research study (1)
 Acceptability:
– Asking children questions about alcohol use was acceptable to
children, parents and school staff
– School staff expressed positive views about research processes
but classroom data collections were sometimes hard to arrange
– Schools which withdrew appear to have done so because of the
work involved in running KAT, not due to research burden

 Participation:
– 69% to 81% children took part
– approximately 6.5% of parents (n=27) took part in telephone
interviews and the data were not analysed
Findings: Feasibility and acceptability
of research study (2)
Measures: Despite piloting and
adaptation, nearly all measures of children’s
demographics, alcohol consumption and
family communication were unsatisfactory
Potential sample size: Likely to need a large
number of schools to detect potential
intervention effects
Conclusions: KAT programme



A reliable mechanism for engaging parents
Concept of an alcohol prevention programme for younger
children was well received
 Children engaged well with the KAT activities and
understood programme content
 Implementation costs are low and KAT could be added to
existing primary-school curricular at little extra expense
 Future programme development - engagement of:
–
less affluent families in programme activities
–
teachers in training for programme delivery
Conclusions:
Value / feasibility of future evaluation
 KAT appeared to have little or no effect on
family communication
– Measurement error?
– Wrong theory?
– Intervention with small effect?

 Low cost of KAT, and large sample size
needed for an effectiveness trial, suggest
that an RCT would not be cost-effective
Conclusions: Future research
 Identification, development and validation of primary and
secondary outcome measures for children aged 9-11
 Inclusion in the design of any future effectiveness trial of:
– adequate time
– agency support
– financial incentives to optimise school recruitment and
retention rates
 Consideration of the role and importance of data from
parents/carers in any future effectiveness trial and the
cost-effectiveness of recruiting them to the research
Acknowledgements
The project Steering Group: John Foster, Faye Gowing (Programme manager),
Marion Henderson (Chair)Chris Roberts, Ruth Saw (Programme manager)
and Harry Sumnall

The project Stakeholder Group: Julie Bishop, Gill Crandon, Gareth Hewitt ,
Angela Latimer, Mary MacDonald, Joan Roberts, Linda Roberts, Alison Thomas,
Emma Toshack and Lyn Webber.
Statistical expertise was provided temporarily by Rebecca Cannings-John
covering for the Trial Statistician
Data collection for the process evaluation was conducted by Anna Flicker

All the
children, parent
s
and school staff
who took part

The KAT project was funded by the National
Institute for Health Research Public Health
Research Programme (project number
10/3002/03)
The views expressed in this presentation are
those of the authors and not necessarily those
of the MRC, NHS, NIHR or the Department of
Health.
Email: segrottj@cardiff.ac.uk
Twitter: @DrJeremySegrott
@DECIPHerCentre

DECIPHer Centre Website
www.decipher.uk.net
Personal website
http://drjeremysegrott.weebly.com/
References
1.
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Perry CL, Williams CL, Veblen-Mortenson S, Toomey TL, Komro KA, Anstine PS, et al. Project Northland:
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Velleman R. Influences on how children and young people learn about and behave towards alcohol. a review of the
literature for the Joseph Rowntree Foundation (part one). York: Joseph Rowntree Foundation, 2009.
9.
Burrell K, Jones L, Sumnall H, McVeigh J, Bellis MA. Tiered approach to drug prevention and treatment among
young people. Liverpool: National Collaborating Centre Drug Prevention, 2005.
10. Bryan H, Austin B, Hailes J, Parsons C, Stow W. On Track Multi-Agency Projects in Schools and Communities: A
Special Relationship. Children & Society. 2006;20(1):40-53.
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systematic review. Health Educ Res. 2007;22(2):177-91.
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Addictive Behaviors. 2002;27(6):867-86.
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prevention and policy. 2000;7(2):109-26.
14. Dishion TJ, Kavanagh K. A multilevel approach to family-centered prevention in schools: Process and outcome.
Addictive Behaviors. 2000;25(6):899-911.
15. Cuijpers P. Three Decades of Drug Prevention Research. Drugs: education, prevention and policy. 2003;10(1):7-20.
16. Stigler MH, Neusel E, Perry CL. School-Based Programs to Prevent and Reduce Alcohol Use Among Youth. Alcohol
Research & Health. 2011;34(2):157-62.
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editor. Delinquency and Crime: Current Theories. Cambridge: Cambridge University Press; 1996. p. 149-97.
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Archives of Pediatrics & Adolescent Medicine. 2012;166(11):1-5.
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21. National Institute for Health and Clinical Excellence (NICE). Interventions in schools to prevent and reduce alcohol
use among children and young people. London: National Institute for Health and Clinical Excellence, 2007 7.
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23. Goodall J, Vorhaus J. Review of best practice in parental engagement Institute of Education, 2011 Contract No.:
DFE-RR156
24. Axford N, Lehtonen M, Kaoukji D, Tobin K, Berry V. Engaging parents in parenting programs: Lessons from
research and practice. Children and Youth Services Review. 2012(0).
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26. Stead M, Stradling B, MacKintosh AM, MacNeil M, Minty S, Eadie D, et al. Delivery of the Blueprint Programme.
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References (contd.)
27. Faggiano F, Galanti MR, Bohrn K, Burkhart G, Vigna-Taglianti F, Cuomo L, et al. The effectiveness of a schoolbased substance abuse prevention program: EU-Dap cluster randomised controlled trial. Preventive Medicine.
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school programme against substance abuse. Drugs: Education, Prevention, and Policy. 2009;16(2):167-81.
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Cochrane Database of Systematic Reviews. 2011(5).
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KAT - ADEPIS seminar

  • 1. Preventing alcohol misuse in young people: implementation, feasibility and acceptability of a primary-school-based intervention with a family component - the Kids, Adults Together (KAT) Programme
  • 2. The KAT research team Jeremy Segrott (PI) Heather Rothwell Simon Murphy Gillian Hewitt Matt Hickman Rebecca Playle Chao Huang Hayley Reed Laurence Moore Cheryl Briscombe
  • 3. Outline of presentation       Background and objectives of the study Methods Intervention Outcomes Results Conclusions
  • 4. Alcohol consumption during childhood and adolescence Harmful consequences in the short term [1, 2] – Accidental injury and death – Sexually transmitted disease – Delinquency and violence – Mental illness – Impaired academic performance Increased risk of long-term dependence and physical, mental and social harm [3] http://news.bbcimg.co.uk/media/images/49617000/jpg/_49617521_underage_drinking-spl.jpg
  • 5. What is known about preventing alcohol misuse (1)?  Need for more evidence of effectiveness of specific programmes targeting children [5]  Some evidence programmes are more effective when children have not started drinking [6,7]  Schools are important locations for universal prevention programmes  maximise reach [8-10]  deliver health curricula  school environment/ethos important
  • 6. What is known about preventing alcohol misuse (2)?  More promising programmes have [11-16] – A clear theoretical basis – Interactive delivery style – Community (including parent/family) involvement  Social Development theory [17] explains importance of interactive delivery and community involvement
  • 7. Social Development Model Perceived opportunities for prosocial interaction Involvement in prosocial interaction Perceived rewards for prosocial interaction Attachment to prosocial others prosocial = positive v antisocial Prosocial values & behaviour
  • 8. Parents’ role in preventing alcohol misuse  Key influence on pre-adolescent children [18-20] – Modelling norms and examples – Controlling access to alcohol – Broader family relationships and communication  When involved in programmes: – exposed to the same messages as children – can reinforce them through actions and attitudes
  • 9. Programmes, primary schools, parents and prevention  Few prevention programmes have been implemented in primary schools with preadolescent children[30]  Most studies have been conducted outside the UK [5]  Many prevention programmes and studies have either not aimed to involve parents or have not met recruitment targets for parent participation [24-28]
  • 10. The Kids, Adults Together (KAT) programme Comprises three components  – – – – Classroom activities on key health issues about alcohol (manual + resources for teachers) Around 20 hours contact time Designed to link into PSE and other curriculum areas A way of addressing other school aims – e.g. parental involvement  Building to a family event at which pupils present their work  Goody bag and DVD for parents and pupils to watch together
  • 11. The Kids, Adults Together (KAT) programme  For 9-11 year-old children at primary schools  Intended effects in reducing alcohol misuse depend on – – parental participation promotion of family communication  Its message is “Not too much, not too soon”  At two pilot schools in 2010 [29] KAT: – engaged 40-50 parents at each of 2 events – was acceptable to children, parents and teachers
  • 12.
  • 13. KAT’s logic model Perceived opportunities for prosocial interaction Classroom preparation, fun evening, DVD, leaflets Involvement in prosocial interaction Interactive learning in classroom and fun evening, making smoothies, watching DVD, family communication Perceived rewards for prosocial interaction Teachers’ and parents’ recognition and appreciation of children’s work Attachment to prosocial others Communication fosters parent-child bond Prosocial values & behaviour
  • 14. Exploratory trial  Design: Exploratory randomised controlled trial  Aim: assess the value and feasibility of conducting an effectiveness trial of KAT  Setting: City in South Wales, UK  Participants: – Primary schools of varied size and sociodemographic profile (FSM entitlement rates) – pupils in Years 5 and 6 (aged 9-11 years) – parents/carers – school staff
  • 15. Exploratory trial Intervention group (n=5)  3 schools ran the KAT programme in addition to any existing alcohol-related lessons / activities  2 schools withdrew without implementing KAT Control group (n=4)  Schools continued with existing lessons / activities Both groups  Baseline + short term follow-up pupil questionnaires  Telephone interviews conducted with parents  Process evaluation conducted to look at implementation
  • 16. Outcomes      quality of programme implementation programme acceptability recruitment and retention of research participants acceptability and feasibility of research processes Acceptability and feasibility of providing demographic data and answering questions about alcohol consumption and family communication  estimates of potential effect and sample sizes
  • 17. Findings: Implementation fidelity  Good overall  ... but some elements better than others  Interactive methods well implemented  ... But not all teachers promoted a healthy approach to alcohol use.  Hard to involve all staff in training/meetings
  • 18. Findings: Programme acceptability  Teachers liked KAT – good fit with curriculum  Children liked interactive work & family involvement  Parents liked the family events – informative, nonjudgemental, non-stigmatising  “Not too much, not too soon” message was well received and understood  Wider implementation: A potential pathway was identified but no funding was available
  • 19. Findings: potential programme effects Intervention effect on family communication: (intermediate outcome): – Mixed evidence from process evaluation interviews with parents – Statistical analysis of children’s questionnaire data showed no evidence of an effect – Some issues with reliability of questionnaire responses
  • 20. Findings: reach 70.0 Did any of your family go to the KAT event? 60.0 50.0 40.0 School 3 School 4 30.0 School 6 20.0 10.0 0.0 FSM (%) Yes (%) No (%) Family members attending (n)
  • 21. Findings: reach Did any of your family go to the KAT event? Responses from 141 pupils who provided data on Family Affluence Score (FAS) Family members attending (total n) High FAS (n=83) No (%) Medium FAS (n=49) Low FAS (n=9) Yes (%) 0 10 20 30 40 50 60 70 80 90
  • 22. Findings: Feasibility and acceptability of research study (1)  Acceptability: – Asking children questions about alcohol use was acceptable to children, parents and school staff – School staff expressed positive views about research processes but classroom data collections were sometimes hard to arrange – Schools which withdrew appear to have done so because of the work involved in running KAT, not due to research burden  Participation: – 69% to 81% children took part – approximately 6.5% of parents (n=27) took part in telephone interviews and the data were not analysed
  • 23. Findings: Feasibility and acceptability of research study (2) Measures: Despite piloting and adaptation, nearly all measures of children’s demographics, alcohol consumption and family communication were unsatisfactory Potential sample size: Likely to need a large number of schools to detect potential intervention effects
  • 24. Conclusions: KAT programme   A reliable mechanism for engaging parents Concept of an alcohol prevention programme for younger children was well received  Children engaged well with the KAT activities and understood programme content  Implementation costs are low and KAT could be added to existing primary-school curricular at little extra expense  Future programme development - engagement of: – less affluent families in programme activities – teachers in training for programme delivery
  • 25. Conclusions: Value / feasibility of future evaluation  KAT appeared to have little or no effect on family communication – Measurement error? – Wrong theory? – Intervention with small effect?  Low cost of KAT, and large sample size needed for an effectiveness trial, suggest that an RCT would not be cost-effective
  • 26. Conclusions: Future research  Identification, development and validation of primary and secondary outcome measures for children aged 9-11  Inclusion in the design of any future effectiveness trial of: – adequate time – agency support – financial incentives to optimise school recruitment and retention rates  Consideration of the role and importance of data from parents/carers in any future effectiveness trial and the cost-effectiveness of recruiting them to the research
  • 27. Acknowledgements The project Steering Group: John Foster, Faye Gowing (Programme manager), Marion Henderson (Chair)Chris Roberts, Ruth Saw (Programme manager) and Harry Sumnall The project Stakeholder Group: Julie Bishop, Gill Crandon, Gareth Hewitt , Angela Latimer, Mary MacDonald, Joan Roberts, Linda Roberts, Alison Thomas, Emma Toshack and Lyn Webber. Statistical expertise was provided temporarily by Rebecca Cannings-John covering for the Trial Statistician Data collection for the process evaluation was conducted by Anna Flicker All the children, parent s and school staff who took part The KAT project was funded by the National Institute for Health Research Public Health Research Programme (project number 10/3002/03) The views expressed in this presentation are those of the authors and not necessarily those of the MRC, NHS, NIHR or the Department of Health.
  • 28. Email: segrottj@cardiff.ac.uk Twitter: @DrJeremySegrott @DECIPHerCentre DECIPHer Centre Website www.decipher.uk.net Personal website http://drjeremysegrott.weebly.com/
  • 29. References 1. Spoth R, Greenberg M, Turrisi R. Preventive Interventions Addressing Underage Drinking: State of the Evidence and Steps Toward Public Health Impact. Pediatrics. 2008;121(Supplement 4):S311-S36. 2. Stone AL, Becker LG, Huber AM, Catalano RF. Review of risk and protective factors of substance use and problem use in emerging adulthood. Addictive Behaviors. 2012;37(7):747-75. 3. Deutsch AR, Slutske WS, Richmond-Rakerd LS, Chernyavskiy P, Heath AC, Martin NG. Causal Influence of Age at First Drink on Alcohol Involvement in Adulthood and Its Moderation by Familial Context. Journal of Studies on Alcohol and Drugs. 2013;74(5):703-13. 4. Currie C, Zanotti C, Morgan A, Currie D, de Looze M, Roberts C, et al. Social determinants of health and well-being among young people. Health Behaviour in School-aged Children (HBSC) study: international report from the 2009/2010 survey. Copenhagen: WHO Regional Office for Europe, 2012 ISBN 978 92 890 1423 6. 5. Foxcroft DR, Tsertsvadze A. Universal alcohol misuse prevention programmes for children and adolescents: Cochrane systematic reviews. Perspectives in Public Health. 2012;132(3):128-34. 6. Nation M, Crusto C, Wandersman A, Kumpfer KL, Seybolt D, Morrissey-Kane E, et al. What Works in Prevention: Principles of Effective Prevention Programs. American Psychologist. 2003;58(6/7):449-56. 7. Perry CL, Williams CL, Veblen-Mortenson S, Toomey TL, Komro KA, Anstine PS, et al. Project Northland: outcomes of a communitywide alcohol use prevention program during early adolescence. American Journal of Public Health. 1996;86(7):956-65. 8. Velleman R. Influences on how children and young people learn about and behave towards alcohol. a review of the literature for the Joseph Rowntree Foundation (part one). York: Joseph Rowntree Foundation, 2009. 9. Burrell K, Jones L, Sumnall H, McVeigh J, Bellis MA. Tiered approach to drug prevention and treatment among young people. Liverpool: National Collaborating Centre Drug Prevention, 2005. 10. Bryan H, Austin B, Hailes J, Parsons C, Stow W. On Track Multi-Agency Projects in Schools and Communities: A Special Relationship. Children & Society. 2006;20(1):40-53. 11. Petrie J, Bunn F, Byrne G. Parenting programmes for preventing tobacco, alcohol or drugs misuse in children <18: a systematic review. Health Educ Res. 2007;22(2):177-91. 12. Marlatt GA, Witkiewitz K. Harm reduction approaches to alcohol use: Health promotion, prevention, and treatment. Addictive Behaviors. 2002;27(6):867-86.
  • 30. References (contd.) 13. Lloyd C, Joyce R, Hurry J, Ashton M. The Effectiveness of Primary School Drug Education. Drugs: education, prevention and policy. 2000;7(2):109-26. 14. Dishion TJ, Kavanagh K. A multilevel approach to family-centered prevention in schools: Process and outcome. Addictive Behaviors. 2000;25(6):899-911. 15. Cuijpers P. Three Decades of Drug Prevention Research. Drugs: education, prevention and policy. 2003;10(1):7-20. 16. Stigler MH, Neusel E, Perry CL. School-Based Programs to Prevent and Reduce Alcohol Use Among Youth. Alcohol Research & Health. 2011;34(2):157-62. 17. Catalano RF, Hawkins JD. The Social Development Model: A Theory of Antisocial Behavior. In: Hawkins JD, editor. Delinquency and Crime: Current Theories. Cambridge: Cambridge University Press; 1996. p. 149-97. 18. Velleman RDB, Templeton LJ, Copello AG. The role of the family in preventing and intervening with substance use and misuse: a comprehensive review of family interventions, with a focus on young people. Drug and Alcohol Review. 2005;24:93-109. 19. Jackson C. Letting children sip: Understanding why parents allow alcohol use by elementary school-aged children. Archives of Pediatrics & Adolescent Medicine. 2012;166(11):1-5. 20. Garmiene A, Zemaitiene N, Zaborskis A. Family time, parental behaviour model and the initiation of smoking and alcohol use by ten-year-old children: an epidemiological study in Kaunas, Lithuania. BMC Public Health. 2006;6(1):287. 21. National Institute for Health and Clinical Excellence (NICE). Interventions in schools to prevent and reduce alcohol use among children and young people. London: National Institute for Health and Clinical Excellence, 2007 7. 22. Estyn. Education about substance misuse: Evaluation of the implementation and impact in schools of the guidance 'substance misuse: children and young people' in welsh assembly government circular 17/02. Cardiff: Estyn, 2007. 23. Goodall J, Vorhaus J. Review of best practice in parental engagement Institute of Education, 2011 Contract No.: DFE-RR156 24. Axford N, Lehtonen M, Kaoukji D, Tobin K, Berry V. Engaging parents in parenting programs: Lessons from research and practice. Children and Youth Services Review. 2012(0). 25. Faggiano F, Vigna-Taglianti FD, Versino E, Zambon A, Borraccino A, Lemma P. School-based prevention for illicit drugs' use. Cochrane Database Syst Rev. 2005:CD003020. 26. Stead M, Stradling B, MacKintosh AM, MacNeil M, Minty S, Eadie D, et al. Delivery of the Blueprint Programme. Stirling: Institute for Social Marketing, 2007.
  • 31. References (contd.) 27. Faggiano F, Galanti MR, Bohrn K, Burkhart G, Vigna-Taglianti F, Cuomo L, et al. The effectiveness of a schoolbased substance abuse prevention program: EU-Dap cluster randomised controlled trial. Preventive Medicine. 2008;47(5):537-43. 28. van der Kreeft P, Wiborg G, Galanti MR, Siliquini R, Bohrn K, Scatigna M, et al. 'Unplugged': A new European school programme against substance abuse. Drugs: Education, Prevention, and Policy. 2009;16(2):167-81. 29. Rothwell H, Segrott J. Preventing alcohol misuse in young people aged 9-11 years through promoting family communication: an exploratory evaluation of the Kids, Adults Together (KAT) Programme. BMC Public Health. 2011;11(1):810. 30. Foxcroft David R, Tsertsvadze A. Universal school-based prevention programs for alcohol misuse in young people. Cochrane Database of Systematic Reviews. 2011(5). 31. Medical Research Council. Developing and evaluating complex interventions: new guidance. [Online at http://www.mrc.ac.uk/Utilities/Documentrecord/index.htm?d=MRC004871]: 2008.