The document discusses the pathology of the endocrine system, focusing on the thyroid gland. It describes the normal histology of the thyroid gland, which includes a capsule, thyroid follicles lined by cuboidal to low columnar epithelium, and colloid material in the follicles. It then discusses two cases: papillary carcinoma of the thyroid showing papillary fronds, orphan Annie's eye nuclei, ground glass optically clear nuclei, and psammoma bodies; and multinodular goiter with multiple nodules in the thyroid gland.

1. PRACTICAL :
PATHOLOGY OF
ENDOCRINE SYSTEM
Dr. Mie Mie Sein
MM 20605

2. Thyroid Gland

3. Thyroid Gland
• Capsule
• Thyroid follicles – lined by cuboidal to low columnar
epithelium
• Colloid material- homogenous, eosinophilic
material
• Parafollicular cells/C cells - in the inter-follicular
spaces

4. HISTOLOGY
Adapted from Nephron (Own work) [GFDL (http://www.gnu.org/copyleft/fdl.html) or CC BY-SA 4.0-3.0-2.5-2.0-1.0
(https://creativecommons.org/licenses/by-sa/4.0-3.0-2.5-2.0-1.0)], via Wikimedia Commons

5. GA 1: Papillary carcinoma thyroid
Adapted from Robbins and Cotran Pathologic basis of disease 9th edition

6. Normal thyroid follicles
Tumour area

7. PAPILLARY FRONDS

8. ORPHAN ANNIE’S EYE NUCLEI
GROUND GLASS OPTICALLY CLEAR

9. PSAMMOMA BODIES

10. GA2:Multinodular Goiter
Adapted from Robbins and Cotran Pathologic basis of disease 9th edition