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NF-kB
1.
The NF-
B/Rel family
2.
3.
4.
Signal transduction pathway
Cytoplasm inactive Nucleus active Signals
5.
NF- B/Rel
proteins
6.
7.
8.
9.
Two main classes
of RHDs +TAD - TAD p105 p50 p100 p52 RelA(p65) cRel RelB Rel homology domain C-terminal I B-like domains Acitvation domains
10.
RHD proteins Ankyrin
repeats RHD
11.
12.
13.
14.
15.
16.
The I-
B family
17.
The I-
B proteins N-terminal Regulatory domain Ankyrin repeats
18.
19.
NF B-I
B complex IkB HMG I(Y)
20.
21.
22.
23.
Signaling pathways
24.
Upstream and downstream
Upstream Downstream NF- k B Signal transduction pathways + + . . + . .
25.
26.
27.
28.
The I
B-kinase complex central in the pathway I B-kinase complex
29.
30.
Stimulus-specific signal transduction
pathways?
31.
32.
33.
34.
35.
The solution Processing
depends on IKK Target of IKK
36.
Model - two
divergent pathways through the IKK complex TNF-R Altered processing of p100 NIK Signal 2 Affect B-cell maturation A role in adaptive immunity A role in innate immunity
37.
38.
Target genes
39.
Upstream and downstream
Upstream Downstream NF- k B Signal transduction pathways + + . . + . .
40.
41.
42.
43.
Disease links
44.
45.
Disease links
46.
47.
48.
49.
50.
51.
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