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FACTORS INFLUENCING (AFFECTING) ON SOLUBILITY OF DRUGS IN SOLVENT SOLUBILITY
FACTORS INFLUENCING (AFFECTING) ON SOLUBILITY OF DRUGS IN SOLVENT
FACTORS INFLUENCING (AFFECTING) ON SOLUBILITY OF DRUGS IN SOLVENT
AMAR RAVAL
Factors Affecting Solubility and Rate of Dissolution Solubility is the ability of a substance to be dissolved in another substance at a specific temperature and pressure. It is also defined as the maximum amount of solute that can be dissolved in a given amount of solvent at a specified temperature and pressure to produce a solution in equilibrium. It is usually expressed in grams of solute per milliliters of solvent. Factors Affecting Solubility 1. Nature of Solute and Solvent A solute can only be dissolved in a solvent when they are “alike.” A general rule is “like dissolves like.” 2. Temperature The solubility of a solid and liquid solute increases when temperature is increased. The solubility of a gaseous solute to a liquid solvent decreases as temperature increases. 3. Pressure The effect of pressure is only applicable for the solubility of gases in liquids. The higher the pressure of a gas, the more soluble it is. Rate of Dissolution The rate of dissolution is defined as how fast a solute dissolves in a given solvent at a specific temperature. The process of dissolving a solute is called dissolution. Factors Affecting the Rate of Dissolution 1. Stirring Stirring a solute will increase its rate of dissolution. When you stir, solute particles come into closer contact more often with solvent particles. 2. Size of the solute particle The smaller the particles of the solute, the faster it dissolves in the solvent. Small particles provide larger surface area for contact with the solvent. 3. Temperature As temperature increases, the rate of dissolution of solid and liquid solutes also increases. 4. Amount of solute present in a solution When you have little amount of solute in the solution, it is easier to dissolve the same solute in the given solvent. However, when you have a lot of solute already present in the solvent, dissolution takes slowly.
Factors Affecting Solubility and Rate of Dissolution.pptx
Factors Affecting Solubility and Rate of Dissolution.pptx
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FACTORS INFLUENCING (AFFECTING) ON SOLUBILITY OF DRUGS IN SOLVENT SOLUBILITY
FACTORS INFLUENCING (AFFECTING) ON SOLUBILITY OF DRUGS IN SOLVENT
FACTORS INFLUENCING (AFFECTING) ON SOLUBILITY OF DRUGS IN SOLVENT
AMAR RAVAL
Factors Affecting Solubility and Rate of Dissolution Solubility is the ability of a substance to be dissolved in another substance at a specific temperature and pressure. It is also defined as the maximum amount of solute that can be dissolved in a given amount of solvent at a specified temperature and pressure to produce a solution in equilibrium. It is usually expressed in grams of solute per milliliters of solvent. Factors Affecting Solubility 1. Nature of Solute and Solvent A solute can only be dissolved in a solvent when they are “alike.” A general rule is “like dissolves like.” 2. Temperature The solubility of a solid and liquid solute increases when temperature is increased. The solubility of a gaseous solute to a liquid solvent decreases as temperature increases. 3. Pressure The effect of pressure is only applicable for the solubility of gases in liquids. The higher the pressure of a gas, the more soluble it is. Rate of Dissolution The rate of dissolution is defined as how fast a solute dissolves in a given solvent at a specific temperature. The process of dissolving a solute is called dissolution. Factors Affecting the Rate of Dissolution 1. Stirring Stirring a solute will increase its rate of dissolution. When you stir, solute particles come into closer contact more often with solvent particles. 2. Size of the solute particle The smaller the particles of the solute, the faster it dissolves in the solvent. Small particles provide larger surface area for contact with the solvent. 3. Temperature As temperature increases, the rate of dissolution of solid and liquid solutes also increases. 4. Amount of solute present in a solution When you have little amount of solute in the solution, it is easier to dissolve the same solute in the given solvent. However, when you have a lot of solute already present in the solvent, dissolution takes slowly.
Factors Affecting Solubility and Rate of Dissolution.pptx
Factors Affecting Solubility and Rate of Dissolution.pptx
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Factors Affecting Solubility
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Factors Affecting Solubility
Joan Santos Elena Villanueva
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and Solvent Insoluble Soluble Ionic Soluble Insoluble Non-Polar Insoluble Soluble Polar Non-polar solvent Polar Solvent Solute
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