Paul Zelisko Brock University March 27 2019 ppt slides

1. +
Ian Gordon
CHEM 2P21
Information
Exercise
March 27, 2019
Happy
Pearl Jacobson, Science Librarian,

9. 1. Download and open ChemDraw
2. Search by chemical/drug by name and insert structure
3. Click on A text box and type in name
4. Centre and/or click on lasso or marquee box to drag text
box and structure
5. Play about and learn the basics or watch any number of tutorial(s)
6. Copy/Scan and paste into Word

28. Xie, H.; Hao, H.; Xu, N.; Liang, X.; Gao, D.; Xu, Y.; Gao, Y.; Tao, H.; Wong, M.
Pharmaceuticals and Personal Care Products in Water, Sediments, Aquatic
Organisms, and Fish Feeds in the Pearl River Delta: Occurrence,
Distribution, Potential Sources, and Health Risk Assessment. Sci. Total
Environ. 2019, 659, 230–239. https://doi.org/10.1016/j.scitotenv.2018.12.222.

33. Napoleon, J. V. ; Manheri, M. K. Direct Transformation of Baylis-
Hillman Acetates into N-Substituted Quinolones through an…
Oxidation Sequence. Synthesis 2011, 20, 3379-3388.

37. Napoleon, J. V.; Manheri, M. K. Direct Transformation of
Baylis-Hillman Acetates into N-Substituted Quinolones
through an SN2′ → SNAr → (Δ3,4-Δ2,3 Shift) → Oxidation
Sequence. Synthesis 2011, 20, 3379-3388.

41. Yachao, L. Chemical Synthesis Method for Norfloxacin. Patent
Application CN 107445892, 2017.

46. Possibly new:
• searching Reaxys chemistry and Espacenet patent databases
• knowledge of SciFinder (MEDLINE / PubMed) and Reaxys (Ovid / Embase) indexing conventions
• using small molecule databases including PubChem, ChemSpider Drugs.com
• accessing commercial chemical manufacturing suppliers e.g. Sigma-Aldrich
• determining whether to make or purchase chemical compounds
• register, download and use ChemDraw chemical drawing software
• being better informed of biochemical research on antibiotics / antibacterial drug development, their chemical
properties, reactions, regulatory and scholarly information
• analyzing and commenting on concepts fundamental to global health and green chemistry

47. +
Ian Gordon
CHEM 2P21
Information
Exercise
March 28, 2018
Happy
Pearl Jacobson, Science Librarian,