1. Aplastic anemia( AA) 再生障碍性贫血 中山大学附属第一医院

4. He looked pallor and had Bilateral legs bleeding spots X-ras showed sever pneumonia

10. fanconi’s anemia

14. Many factors activate T-cell,manly CD4D8cells which injure stem cell and secrete inhibitor factors like INFNF-a inhibiting bone marrow hematopoietic function pancytopenia infection, bleeding, anemia Mechanisms hypocellularity of the bone marrow T cell APLASTIC ANEMIA

15. Young NS, et al. N Engl J Med 1997;336:1365–1372

23. 检验 2 骨髓涂片外观 There are a lot of fat drops on the smear of AA

24. 2 Bone marrow hypocellularity 骨髓小粒空虚，成空网状结构，其中造血细胞减少 normal bone marrow

25. Bone marrow biopsy 骨髓造血组织面积减少（ <10%) ，主要组分由脂肪细胞所构成，可见灶性出血。 骨髓造血活跃 Normal AA

27. 七、 severe 、 non-severe AA PLT ﹥20×10 9 / L PLT <20×10 9 / L moderate hypocellularity severe hypocellularity bone marrow NEC﹥0.5×10 9 / L NEC<0.5×10 9 / L RET ﹥1% -<1.5% RET<1% blood non-severe AA severe AA

33. Reconstruction Hematopoiesis Principle of All0-HSCT is by using immune suppression to inhibit the receptor immune function ， allo dornor stem cells start normal hematopoiesis T cell IST IST Allo HSC

36. Restore Hematopoiesis patients only use immunosuppressive therapy(IST) ， The time of restoring hematopoiesis will be long because of no dornor stem cell T cell IST IST

41. British Journal of Haematology, 2009,147, 43–70 再障的治疗选择 英国血液学标准委员会 2009

46. He is still alive up to now (8 years) patient donor

48. 谢谢