a motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes (muscle tone) with exaggerated tendon jerks, resulting from hyperexcitability of the stretch reflex
16. Botulinum Toxin Type A (BOTOX ® ) : History of Development 1944 1920s 1895 Botulinum toxin type A first isolated Dr. Schantz begins investigation C. botulinum identified Dr. Scott initiates first therapeutic testing in humans 1978 1989 FDA approval of BOTOX ®