noticias biologia molecular

1. Mutation Rates in Cancer Cells Strongly
Linked to How Chromatin Is Organized.
And
Microbiologists reveal how T. brucei’s key
Ttulo dos noticias
proteins organize to replicate its mtDNA.
Su nombre

2. Medical utility Bibliography Mutation Rates in
Genetics can meet normal Cancer Cells Strongly
and abnormal processes - MARTINEZ S, Lina María.
Linked to How
in living organisms, Biología Molecular. 5 ed
Medellín: UPB Fac. Medicina Chromatin Is
understanding this
process will give us a Organized
broad knowledge of, as - Microbiologists reveal how T.
sick and why, and how to brucei’s key proteins organize to
replicate its mtDNA, Published on
do some early intervention
July 11, 2012 Universidad de
in disease processes. This
Massachusetts en Amherst.
study with efforts to
prevent the progression of - Mutation Rates in Cancer Cells Microbiologists reveal
diseases that kill millions Strongly Linked to How
of people each year, an how T. brucei’s key
Chromatin Is Organized.
important aspect of these ScienceDaily (July 26, 2012). proteins organize to
studies is to try to cure replicate its mtDNA
diseases without affecting
people who have them,
avoiding side effects are
often worse than the very
disease.
Jhon M. Cardona Betancur
Medicine Student -III
Semester.
Universidad Pontificia
Bolivariana
Molecular Biology- August 6
2012

3. Introduction ScienceDaily (July 26, 2012) Published on July 11, 2012
Mutation Rates in Universidad de Massachusetts en
Amherst
Studies to treat diseases Cancer Cells Strongly Microbiologists reveal
that affect humans are Linked to How how T. brucei’s key
made on many fronts, Chromatin Is proteins organize to
studying conditions of the Organized. replicate its mtDNA.
host, the environment, or
conditions own the Cancer is perhaps the area For many years, parasitic
organism, these studies where more research is diseases have affected
focus on the mechanisms done in this case, the thousands of people, and
by which reproduction is investigation focuses on has tried to avoid and cure
given of the cells of these the organization of them with little success in
microorganisms and the chromatin as cause of some areas of the world,
way to block these mutations that ultimately one possible cause is that
processes. become cancer. the treatment can affect the
host is looking for ways to
work around this.
Student observation: all work
carried out in cancer will always be
Student observation: Knowledge of
welcome, but even if they are made
the mechanisms used by
so that the least possible impact to
microorganisms to survive, gives
patients and their quality of life.
us tools to attack them more
effectively and with less affectation
to our health.

4. Introduction
Studies to treat diseases that affect
humans are made on many fronts,
studying conditions of the host, the
environment, or conditions own the
organism, these studies focus on the
mechanisms by which reproduction is
given of the cells of these
microorganisms and the way to block
these processes
conditions of the host
investigations focused on:
Environment
conditions
conditions of the
microsorganism

5. ScienceDaily (July 26, 2012)
Mutation Rates in Cancer Cells
Strongly Linked to How
Chromatin Is Organized.
Cancer is perhaps the area where
more research is done in this case, the
investigation focuses on the
organization of chromatin as cause of
mutations that ultimately become
cancer.
Student observation: all work carried
out in cancer will always be welcome,
but even if they are made so that the
least possible impact to patients and
their quality of life

6. Mutation Rates in Cancer Cells
Strongly Linked to How
Chromatin Is Organized.
Disease in which the body produces abnormal cells derived from the
tissues themselves. These are generally characterized by escape
reproductive control that required their original function, losing its
original capabilities, and over time, acquiring others that are not theirs,
invading progressively and by different routes nearby organs, or even
remotely via the lymphatic or hematogenous

7. Mutation Rates in Cancer Cells
Strongly Linked to How
Chromatin Is Organized.
cells in their body has a length of one
meter in the same DNA. In order to
properly package all the DNA in the cell
nucleus, to be mounted on a structure
called "chromatin".
To form chromatin, the nucleosomes are
bound together by another histone
proteins called H1. H1 winds the
nucleosomes together into a chromatin
fiber that is about 30 nanometers in
diameter. These chromatin fibers are
looped into a 300 nanometer coiled
chromatin fiber, and these coiled
chromatin fibers are then wound into 700
nanometer condensed chromatin

8. Mutation Rates in Cancer Cells
Strongly Linked to How
Chromatin Is Organized.
Chromatin
Euchromatin Heterochromatin
Chromatin Is transcriptionally inactive
genetically active in and is highly repetitive DNA
interface rolled out sequences,
Constituent Optional
Formed by DNA sequences Contains
are not transcribed as sequences that
sequences satellite located are transcribed in
in the centromeres of some cell types.
chromosomes.

9. Mutation Rates in Cancer Cells
Strongly Linked to How
Chromatin Is Organized.
Observation
This study is based on existing information as
the basis of the human genome, also generated
new information that may be used by other
researchers around the world for the benefit of
patients with cancer, given the importance that
we can learn more about the causes of cancer.
But can also be used to understand some of the
basic problems of genetics, such as why some
regions of the genome mutate faster than others.
and you can do to prevent this.

10. Published on July 11, 2012
Universidad de Massachusetts en Amherst
Microbiologists reveal how T.
brucei’s key proteins organize to
replicate its mtDNA
For many years, parasitic diseases
have affected thousands of people, and
has tried to avoid and cure them with
little success in some areas of the
world, one possible cause is that the
treatment can affect the host is looking
for ways to work around this.
Student observation: Knowledge of the
mechanisms used by microorganisms
to survive, gives us tools to attack them
more effectively and with less
affectation to our health.

11. Microbiologists reveal how T. brucei’s
key proteins organize to replicate its
mtDNA
Human African trypanosomiasis, also known
as sleeping sickness is a parasitic disease
transmitted by a vector. The parasites that
cause it are protozoa belonging to the genus
Trypanosoma. Are transmitted to humans by
the bite of the tsetse fly (genus Glossina) has
contracted the infection of humans or
animals that harbor the parasites
pathogenic to humans
Sleeping sickness occurs only in 36 sub-
Saharan Africa where there are tsetse flies
that can transmit it. People who are more
exposed to contact with the tsetse fly and
therefore to the disease are the rural people
engaged in agriculture, fisheries, livestock
or hunting.

12. Microbiologists reveal how T. brucei’s
key proteins organize to replicate its
mtDNA
The cell structure is typical with all eukaryotic organelles,
including the nucleus, mitochondria, endoplasmic reticulum,
Golgi apparatus and so on. The main unusual features include
a single large mitochondria with a condensed mitochondrial
DNA structure
Cicle of
tripanosome
brucei

13. Microbiologists reveal how T. brucei’s
key proteins organize to replicate its
mtDNA
Immunofluorescence experiments
focused set to follow its desired path,
known as the identification of mtDNA Matriz mitocondrial
polymerase (POLID). mitochondrial DNA
Proteínas de
mitochondrial
Granule
Ribosomal inner
membrane
intermembrane
They found a mechanism how this protein is space
involved in kDNA replication. In response to outer
changes during kDNA replication cycle, membrane
POLID redistributed, changing location of
the mitochondrial matrix approaches
concentrated around the kDNA, and
dynamically relocalizaba the withdrawal of
the molecules of kDNA.

14. Microbiologists reveal how T. brucei’s
key proteins organize to replicate its
mtDNA
Observation
Knowing the mechanism by which
microorganisms survive gives us
tools to attack them in a more
selective, without using toxic
substances that alter the health of
the person concerned.
The importance of this study is that
it can also improve control of other
parasitic type diseases.

15. Medical utility
Genetics can meet normal and
abnormal processes in living
organisms, understanding this process
will give us a broad knowledge of, as
sick and why, and how to do some
early intervention in disease
processes. This study with efforts to
prevent the progression of diseases
that kill millions of people each year, an
important aspect of these studies is to
try to cure diseases without affecting
people who have them, avoiding side
effects are often worse than the very
disease.

16. Medical utility
The development of
increasingly
selective drugs for
their site of action in
the future allow
more timely action
on the affected
organ or even more
on the molecule
defective

17. Medical utility
The studies conducted on the human
genome, deciphering every day but the
tangle of questions there in front of the
origin and explanation of many pathologies.
Also reoriented many studies are underway.

18. Medical utility
The medicine of the future
must address problems even
before they appear, making
diagnosis by genes that have
an individual.
It could also have resources
to intervene in the DNA in
many ways one could be
nanotechnology, which would
allow damage repair and
embed information in the dna
of an individual.

19. Bibliography
- MARTINEZ S, Lina María. Biología Molecular. 5 ed Medellín: UPB
Fac. Medicina. Pag 46
- Mutation Rates in Cancer Cells Strongly Linked to How Chromatin
Is Organized. ScienceDaily (July 26, 2012).
- Microbiologists reveal how T. brucei’s key proteins organize to
replicate its mtDNA, Published on July 11, 2012 Universidad de
Massachusetts en Amherst

20. Science and life can not and must be separated.
For me science gives a partial explanation of life.
Mutation Rates in Cancer Cells Strongly Linked to How Chromatin Is Organized
As it is based on facts, experience and
experiments ... I agree that faith is essential to
succeed in life, but I do not accept your definition
of faith, the belief that there is life after death.
In my opinion, all you need is faith the belief that
striving to do the best we can we will come to
success, and success for our purposes, the
improvement of mankind today and the future, it
is penalty to be achieved.
Rosalind Franklin 1940