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DKR
Generations in Asymmetric Synthesis
1st
Generation – Substrate-controlled Asymmetric synthesis
Diastereoselective reaction...
Overview of generations
This is what called as 1,2-asymmetric induction
2
1 2 1
How does the center control the direction of attack at the triagonal carbon ?
Cram’s Rule
Nature is a good chemist. It will give 100% e.e.
Any Questions !!!
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
Asymmetric synthesis
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Asymmetric synthesis

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Presentation on Asymmetric synthesis

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Asymmetric synthesis

  1. 1. DKR
  2. 2. Generations in Asymmetric Synthesis 1st Generation – Substrate-controlled Asymmetric synthesis Diastereoselective reactions where the formation of a chiral centre is controlled by another chiral centre already present in the substrate. 2nd generation – Auxiliary-controlled Asymmetric synthesis Methods where a chiral auxiliary is covalently attached to the substrate and, through that, controls the asymmetric induction. This strategy, with intermolecular controlled induction, is basically the same in first- and second-generation methods. The difference is the attachment and removal of the auxiliary in the latter. 3rd generation – Reagent-controlled Asymmetric synthesis The formation of a new chiral centre is induced by a chiral reagent or catalyst, intermolecularly. 4th Generation – Catalyst-controlled Asymmetric synthesis Catalytic modifications of the first-, second-, and third-generation methods tend to be considered together with this new fourth-generation. One general procedure involves a reaction of a chiral substrate with a chiral reagent, and is especially useful in reactions where two new stereogenic units are formed stereo selectively in one step.
  3. 3. Overview of generations
  4. 4. This is what called as 1,2-asymmetric induction 2 1 2 1
  5. 5. How does the center control the direction of attack at the triagonal carbon ? Cram’s Rule
  6. 6. Nature is a good chemist. It will give 100% e.e.
  7. 7. Any Questions !!!

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