a brief presentation on hydrogels

1. Presented By: SANDEEP MOLLIDAIN M.Pharmacy (pharmaceutical technology) Dept. of pharmaceutical technology. Vsp.

7. Classification Of Hydrogels:

33. Monomers Used In The Synthesis Of Synthetic Hydrogels: Monomer abbreviation Monomer HEMA Hydroxyethyl methacrylate HEEMA Hydroxyethoxyethyl methacrylate HDEEMA Hydroxydiethoxyethyl methacrylate MEMA Methoxyethyl methacrylate MEEMA Methoxyethoxyethyl methacrylate

34. Monomers Used In The Synthesis Of Synthetic Hydrogels: Monomer abbreviation Monomer EG Ethylene glycol EGDMA Ethylene glycol dimethacrylate NVP N-vinyl-2-pyrrolidone AA Acrylic acid PEGMA PEG methacrylate

36. Crosslinking: Linear polymers Crosslinking Chemical compounds Irradiation Monomers used in the preparation of the ionic polymer network contain an ionizable group, gets ionized, or undergoes substitution after the polymerization is completed.

38. Isostatic Ultra High Pressure : ultrahigh pressure of 300-700 MPa gelatinization of starch molecules occur. IUHP brings about changes in the morphology of the polymer. Where as heat-induced gelatinization (40 to 52°C) causes a change in ordered state of polymer. Suspension of natural biopolymers (starch) 5or 20 min

39. Nucleophilic Substitution Reaction: Methacyloyl chloride 2-dimethylamino ethylamine. Nucleophilic substitution. N-2-dimethyl amino ethyl-methacryalmide (DMAEMA) (a pH and temperature sensitive.)

43. Characterization Of Hydrogels:

50. Swelling Behavior: The SD was calculated as follows: W0 = Weight of the original Hydrogel Wt = is the weight of hydrogel at various swelling times SD (%)= (Wt/Wo)×100 Picture of a swollen Hydrogel

68. Common Uses For Hydrogels:

85. Subcutaneous delivery: * Prevention of protein adsorption and cell adhesion arising from the low interfacial tension between water and hydrogels; * Broad acceptability for individual drugs with different hydrophilicities and molecular sizes * Unique possibilities to manipulate the release of incorporated drugs by crosslinking density and swelling.

87. Hydrogels To Fix Bone Replacements:

99. References: 1.Remington: The Science and Practice of Pharmacy. Published by Lippincott Williams & Wilkins, 2005. Twenty-First Editions. P.NO. 294,756,867,868. 2. Handbook of Pharmaceutical Excipients, A. Wade and P.J. Weller ed., The Pharmaceutical Press, London, 1994, pp. 229–232. 3. British Pharmacopoeia 2002, the Stationary Office, London, 2002, p. 2092–2094.

100. Thank You