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International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169
Volume: 5 Issue: 10 54 – 58
_______________________________________________________________________________________________
54
IJRITCC | October 2017, Available @ http://www.ijritcc.org
_______________________________________________________________________________________
Review on Optic Disc Localization Techniques
G.Jasmine
PG Scholar
Department of computer Science and Engineering
V V College of Engineering
Tisaiyanvilai, India
jasminenesathebam@gmail.com
Dr. S. Ebenezer Juliet M.E., Ph.D.,
Department of Computer Science and Engineering
V V College of Engineering
Tisaiyanvilai
juliet_sehar@yahoo.com
Abstract-The optic disc (OD) is one of the important part of the eye for detecting various diseases such as Diabetic Retinopathy and
Glaucoma. The localization of optic disc is extremely important for determining hard exudates and lesions. Diagnosis of the disease can prevent
people from vision loss. This paper analyzes various techniques which are proposed by different authors for the exact localization of optic disc to
prevent vision loss.
Keywords: Localization, Optic Disc (OD), Corner Detector, Vessel Convergence, Vessel Enhancement
__________________________________________________*****_________________________________________________
I. INTRODUCTION
The retina is thin layer of tissue, in which the blood
vessels are clearly visualized. Its purpose is to receive the light
and convert it to neural signals and these signals are send to
the brain for the visual recognition [16]. The brightest region
in the retinal image is the optic disc. The blood vessels
originate from the center of optic disc. It is classified
according to its size. The slit lamp examination is done with
fundocopic lens from which vertical and horizontal disc
diameter are obtained. The Optic disc cup increase in size with
the disc size, where large cups are obtained in healthy eyes. It
is also called as optic nerve head and blind spot [3]. Optic disc
is not sensitive to light because of the absence of light
sensitive rods and cone in the retina, so it is called as blind
spot. Optic disc is located in the vessel convergence region.
The localization of optic disc is done mainly to save people
from vision loss.
Fig 1. Optic Disc
Optic disc is mainly used for detecting various diseases
such as diabetic retinopathy and glaucoma. It can also be used
for the detection of other anatomical structures such as macula
and retinal vessels [10].
The major health problem that has increased recently is
the Diabetic retinopathy. It is an asymptomatic disease which
can lead to loss of vision. About 10,000 people lose their
vision due to diabetic retinopathy.
Retinal Treatment is the best method for reducing the
vision loss. Regular eye examinations are required for
detecting and treating the diabetic retinopathy [10].
The detection of optic disc in retinal image is very
important for the exact localization of optic disc. To find the
abnormal structures in the image it is to be mask out from the
analysis. Optic disc detection is one of the important step for
diabetic retinopathy and glaucoma for screening system. The
optic disc boundary and the localization of macula is used for
the detection of exudates and diabetic maculopathy. In diabetic
maculopathy masking the false positive OD leads to improve
in performance of lesion detection. The OD position is used as
a reference length for measuring the distances in retinal
images. The location of OD becomes the starting point for
vessel tracking. Thus the optic disc localization is performed
[4].
II. Techniques For Optic Disc Localization
Optic disc localization is extremely important for
determining the hard exudate lesions or nonvascularization.
By localizing the optic disc, blindness can be reduced. To
localize Optic Disc various methods are available. In this
survey some of the methods are discussed below.
2.1 Approximate nearest neighbor field based optic disc
detection
A feature match ANNF algorithm Proposed in [14],
to find the correspondence between the optic disc images. The
correspondence between the images provides patches in the
query image which are close to the reference image. This
method uses only one retinal image which is used to extract
the reference optic disc image. The given input image is
preprocessed, in which reference optic disc is considered as an
algorithm and the target image is considered as feature match.
Then query image is preprocessed, i.e. it is equalized and
converted to grayscale. ANNF searches the nearest patches
International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169
Volume: 5 Issue: 10 54 – 58
_______________________________________________________________________________________________
55
IJRITCC | October 2017, Available @ http://www.ijritcc.org
_______________________________________________________________________________________
with low dimension, but it does not produce exact match.
Accuracy is improved by using image coherency. The ANNF
map point out the location of patches in query image which is
same as of the reference image. Using these patches, the
likelihood map (L) is computed. By using this L map the
maximum location is find out to localize the optic disc.
2.2 Feature match: A general ANNF estimation
technique and its Applications
ANNF algorithm Proposed in [13], to estimate the
mapping between image pairs. This generalization is achieved
by spatial-range transforms and it enables to handle various
vision applications, 1) optic disc detection- It mainly focus on
medical images, for the localization of optic disc to produce as
a target image. 2) super- resolution- It focus on synthetic
images, which uses source image. The input is a reference
image, which provides template for OD. It extracts the
template from grayscale image, after histogram equalization.
The optic disc which is extracted from the image forms a
target image. The reference image is preprocessed as like
query image. Likelihood map is initialized, to find the optic
disc location in the image. After initialization of L map, it find
out the number of times each patch is mapped in the query
image. By using the L map it estimates the optic disc location.
2.3 Retinal vessel segmentation by improved matched
filtering-evaluation on a new high-resolution fundus image
database
Segmentation of retinal vessels proposed in [12], to
segment the blood vessels in the fundus images. The
segmentation uses MF approach in the preprocessed image.
The preprocessed image with five kernals, rotates into 12
orientations. The parametric image gets fused, so maximum
responses are selected for each pixel. A blood vessel tree is
obtained after threshold of fused image. The noise of the
image structures are removed using morphological operators.
A B-spline correction method is used to improve the accuracy
of the proposed method. The two-dimensional MF exploits the
correlation between image areas. The maximum response is
selected from the set of parametric images for each pixel by
using joint parametric image. The image is thresholded to
obtain vascular tree. The blood vessels are considered as
objects and remaining parts are considered as background of
the image, where pixels inside the FOV are selected. The
result of the thresholding algorithms are evaluated and
compared using HRF database. Finally, morphological
cleaning method is used to remove the artifacts, which are not
connected to the vessel tree.
2.4 Teleophta: Machine learning and image processing
methods for teleophthalmology
Diabetic retinopathy screening proposed in[2], is
done by using teleopthalmology screening, in which image
deals with the normalization technique, which uses FOV
photographs as size invariant. The parameters are defined
based on the size. Then segmentation is done for border
reflections. The reflections appear as bright and moon shaped
regions. Then segmentation carried out. Then detection takes
place and vessels are segmented and OD is detected and
finally the macula. The vessel masks are analyzed to extract
the structures. The detection starts with threshold to select
bright regions as like optic disc. The vessel mask which is
previously computed is used to select the correct position of
the optic disc. An exudates detection method is developed for
a heterogeneous database. The exudates regions are extracted
by using the morphological opening operation method. Finally
each exudate region of 30 characteristics is extracted for the
purpose of training a random forest model. A random forest
classifier is used to compute the risk of each exudates region.
2.5 Fast Localization and Segmentation of Optic Disc in
Retinal Images Using Directional Matched Filtering and
Level Sets
The OD localization and segmentation algorithm
proposed in [15], are used for the retinal disease screening.
The OD locations are identified in the image using template
matching. It is then designed to adapt various image
resolutions. Then the patterns in OD determine the location. A
hybrid levelset model is used to combine both the region and
the local gradient information that is applied to the disc
boundary segmentation. The blood vessels are removed using
morphological filtering operation. The OD size can be
calculated by FOV camera. Then the OD candidates are find
out by using CIElab lightest image. Then the result is the
normalized image. The optic disc candidates are selected
according to the template responses. The segmentation uses
morphological reconstruction to suppress the bright regions.
At last the performance is evaluated by the combination of two
test images.
2.6 Accurate and Efficient Optic Disc Detection and
Segmentation by a Circular Transformation
OD detection and segmentation technique proposed
in [7], is used for the circular transformation, which captures
the shape of the optic disc and variation in the optic disc
boundary. First a retinal image is derived by combining both
the red and green components it determines the intensity of the
image. Then preprocessing takes place. According to the shape
of the OD and the variation in the OD boundary the circular
transformation is designed. Finally retinal image is converted
to the OD map. Then optic disc is localized.
2.7 Automatic Optic Disc Detection from Retinal
Images by a Line Operator
An optic disc detection technique proposed in [8], is
used to extract the lightness portion in the retinal image. The
retinal images are preprocessed before the detection of optic
disc. Then it is smoothed to enhance the brightest region
associated with optic disc. Then the circular regions are
detected using the line operator. The optic disc is located
accurately using the orientation of the line segment. By using
orientation map the optic disc is localized. The classification is
done between the peak center and the surrounding of the peak
center. By the combination of the peak amplitude and the
image intensity the optic disc is detected.
2.8 Fast Localization of the Optic Disc Using Projection
of Image Features
Optic Disc brightness and retinal vessel orientations
features proposed in [9], based on two projections of image
features that encode x coordinate and y coordinate of the optic
disc. The one dimension projections determine the location of
optic disc. It avoids two dimension image space and it
improves the speed of the localization process. For the
localization of OD, the process gets split into two steps. First
the horizontal location of OD is determined using the image
features that are projected to the horizontal axis. In Second
step it determines the correct vertical location. Assume, if
horizontal location is successfully identified, then the only aim
International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169
Volume: 5 Issue: 10 54 – 58
_______________________________________________________________________________________________
56
IJRITCC | October 2017, Available @ http://www.ijritcc.org
_______________________________________________________________________________________
is to find the correct vertical location. This can be found by
feature_map_2 on the vertical axis. It is then find out as the
maximum peak of the one dimensional signal.
2.9 Automated optic disc detection in retinal images of
patients with diabetic retinopathy and risk of macular
edema
The optic disc detection proposed in [1], based on
two methodologies. On one side it belongs to the image
contrast and the structure filtering techniques optic disc
location and on other side edge detection technique and Hough
transform are used for the circular approximation of the optic
disc. For the localization of optic disc there are three detection
methods they are, 1) Maximum difference method- which
provide the difference between the maximum and minimum
calculation of the images using filter. 2) Maximum variance
method- The maximum pixels are selected which are located
in the brightest region. 3) Low pass filter method- It returns
highest grey pixel. The OD boundary provides a circular
approximation of optic disc using segmentation. The original
retinography are extracted using the pixel in the optic disc.
The coordinates are provided using localization
methodologies, 1) The blood vessels are eliminated using
dilation and smoothing are done using filter. 2) The gradient
magnitude is obtained using prewitt operator. 3) The noise of
the image is reduced using morphological erosion. 4) Finally
circular approximation of optic disc is obtained using Hough
transform.
2.10 Fast detection of the optic disc and fovea in color
fundus photographs
KNN regressor technique proposed in [11], used to
predict the pixel distance, based on several features. The
lowest distance in the fovea is selected as fovea location. First
the image is preprocessed. Then the gradient magnitude is
calculated by the detection of FOV in the red plane of the
image. The optic disc and fovea localization uses green plane.
The green plane image is blurred using a Gaussian filter to
remove the low frequency gradients. The anatomical structure
problems are defined as a regression problem. The goal is to
find the dependent variable. The threshold is applied to get a
vessel map. This method combines the cues that is measured
directly and the segmentation of retinal vasculature. The optic
disc center is selected according to the lowest predicted
distance of optic disc. Using this, fovea is defined and it is
selected as the fovea location in the fovea search area.
2.11Feature extraction in digital fundus images
An exudate segmentation algorithm proposed in [5],
used to enhance the exudates regions. First the image is
preprocessed to improve the contrast of the lesions. Next optic
disc is eliminated using entropy. A Fuzzy c-means clustering
algorithm is used to extract the exudates regions. The FCM
algorithm changes to standard FCM using spatial
neighborhood information. Then vessel skeleton map is
obtained. The neighbor pixels are obtained for each skeleton
pixel. The vessels are detected by identifying the pixels with
one neighbor vessel pixel. The disc boundary is detected using
contour model. First image is preprocessed, then dilation
carried out and OD boundary is determined. Then FCM
algorithm is used to segment the exudates. Finally SVM
classification is used to provide the exact lesion from non-
lesion.
TABLE 1: COMPARATIVE ANALYSIS OF OPTIC DISC LOCALIZATION TECHNIQUES
PAPER TITLE ALGORITHMS/
METHODS
FEATUR ES BENEFITS DRAWBACKS
Approximate Nearest
Neighbor Field based optic
disc detection [14]
 Optic Disc Location-
Approximate Nearest
Neighbour.
Shape, Colour, Brightness
 Performance is good.
 Less computation
time.
 Less accuracy.
 Dislocation of optic
disc.
Feature match: A general
ANNF estimation technique
and its Applications [13]
 Feature Extraction-
Walsh Hadamard
Transformation.
 K-NN Search- KD-
tree algorithm.
Colour,
Gradient  Accuracy is good.
 Coherency is good.
 Regeneration of color
information becomes a
difficult problem.
 Differences in image
intensities.
Retinal vessel segmentation
by improved matched
filtering-evaluation on a new
high-resolution fundus image
database [12]
 Preprocessing- B-
Spline- based
illumination
correction.
 Correlation detection
between images- 2D
Match Filtering.
Shape, Intensity
 Reduces the false-
positive detections.
 High Resolution.
 Poor Performance.
 Evaluation is
performed on low-
resolution images.
Teleophta: Machine learning
and image processing
methods for
teleophthalmology [2]
 Preprocessing- Field
of View.
 Anatomical detection-
Morphological filter.
Size, Shape, Contrast
 Small vessels can be
detected.
 Help in rising of new
population health
challenges.
 Lowers the
specificity.
 Poor Performance.
International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169
Volume: 5 Issue: 10 54 – 58
_______________________________________________________________________________________________
57
IJRITCC | October 2017, Available @ http://www.ijritcc.org
_______________________________________________________________________________________
Fast Localization and
Segmentation of Optic Disc
in Retinal Images Using
Directional Matched
Filtering and Level Sets
[15]
 OD Size Estimation-
Field Of View and
image resolution.
 OD Segmentation-
morphological
processing.
 OD Localization-
Template Matching.
Size, Shape, Brightness
 Increase robustness.
 Accuracy of Optic
Disc detection.
 It is expensive.
 Optic Disc detection
is difficult.
Accurate and Efficient Optic
Disc Detection and
Segmentation by a Circular
Transformation [7]
 Preprocessing- Down-
Sampling.
 OD Segmentation and
Detection- B-Spline
Filtering.
Shape, Brightness
 Algorithm runs faster.
 Accuracy gets
improved.
 OD segmentation may
introduce error.
 Optic Disc boundary
pixels cannot be
determined based on
symmetry.
Automatic Optic Disc
Detection from Retinal
Images by a Line Operator
[8]
 Preprocessing-
Bilateral smoothing
Filter.
 Circular Detection-
Line Operator.
 OD Detection- 2D
Circular convolution
Mask.
Brightness, Image Variation
 High Detection speed.
 Retinal lesions can be
tolerated.
 Poor Performance.
 Various types of
imaging artifacts
cannot be handled.
Fast Localization of the
Optic Disc Using Projection
of Image Features [9]
 OD Localization-
Model based method.
Space, Intensity
 Less computation
time.
 Search-space
dimensionality is
reduced.
 It is expensive.
 Robustness for
localization of OD is
difficult.
Automated OD
detection in retinal images of
patients with diabetic
retinopathy and risk of
macular edema [1]
 OD Localization-
Maximum difference
and variance method,
Low-pass filter
method.
 Segmentation of OD-
Dilation, Prewitt
operator, Erosion,
Circular Hough
Transform.
Shape, Colour, Depth
 Accuracy is increased.
 Robustness is
increased.
 Poor Computation
time.
 High Megabytes
images are not
accepted.
Fast detection of the optic
disc and fovea in color
fundus photographs [11]
 Preprocessing- Field
Of View.
 Position Regression –
Regression
Size, Space
 Performance is
increased.
 Increase in robustness.
 Poor contrast.
 Does not make strong
assumption
III. Conclusion
This paper analyzes various techniques which are proposed
by different authors for localizing the optic disc. Diabetic
retinopathy leads to vision loss, where various preventive
measures are taken to save people from vision loss. It focuses
on the localization of optic disc. Various approaches are used
for OD localization they are, Approximate Nearest Neighbour
Field (ANNF), optic disc detection technique and Match
filtering methods. These techniques are used to localize the
exact optic disc. The performance is decreased due to optic disc
dislocation. In future advanced algorithm can be used to
improve the performance.
REFERENCES
[1] A. Aquino, M. E. Gegundez, and D. Marin, “Automated optic
disc detection in retinal images of patients with diabetic
retinopathy and risk of macular edema”, International Journal
of Biological & Life Sciences, Vol. 8, No. 11, pp. 87, 2010.
[2] E. Decencire, G. Cazuguel, X. Zhang, G. Thibault, J.
C. Klein, F. Meyer, B. Marcotegui, G. Quellec, M. Lamard,
R. Danno, D. Elie, P. Massin, Z. Viktor, A. Erginay, B. La,
and A. Chabouis, “Teleophta: Machine learning and image
processing methods for teleophthalmology”, fIRBMg, Vol.
34, No. 2, pp. 196 – 203, 2013.
[3] Dehghani, Amin, Hamid Abrishami Moghaddam, and
Mohammad-Shahram Moin, “Optic disc localization in retinal
International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169
Volume: 5 Issue: 10 54 – 58
_______________________________________________________________________________________________
58
IJRITCC | October 2017, Available @ http://www.ijritcc.org
_______________________________________________________________________________________
images using histogram matching”, EURASIP Journal on
Image and Video Processing, No. 1, pp. 1-11, 2012.
[4] Godse, A. Deepali, and Dr. S. Dattatraya Bormane,
“Automated localization of optic disc in retinal images”,
(IJACSA) International Journal of Advanced Computer
Science and Applications 4, No. 2, 2013.
[5] G. B. Kande, P. V. Subbaiah, and T. S. Savithri, “Feature
extraction in digital fundus images”, Journal of Medical and
Biological Engineering, Vol. 9, No. 3, pp. 122–130, 2009.
[6] S. Lu, “Accurate and efficient optic disc detection and
segmentation by a circular transformation”, IEEE
Transactions on Medical Imaging, Vol. 30, No. 12, pp. 2126–
2133, 2011.
[7] S. Lu and J. H. Lim, “Automatic optic disc detection from
retinal images by a line operator”, IEEE Transactions on
Biomedical Engineering, Vol. 58, No. 1, pp. 88–94, 2011.
[8] A. Mahfouz and A. Fahmy, “Fast localization of the optic disc
using projection of image features”, IEEE Transactions on
Image Processing, Vol. 19, No. 12, pp. 3285– 3289, 2010.
[9] D. Michael, Abràmoff, K. Mona Garvin, Milan Sonka,
“Retinal Imaging and Image Analysis”, IEEE Transactions on
Medical Imaging 3, pp. 169-208, January 2010.
[10] M. Niemeijer, M. D. Abrmoff, and B. Van Ginneken, “Fast
detection of the optic disc and fovea in color fundus
photographs”, Medical Image Analysis, Vol. 13, No. 6, pp.
859 – 870, 2009.
[11] J. Odstrcilik, R. Kolar, A. Budai, J. Hornegger, J. Jan, J.
Gazarek, T. Kubena, P. Cernosek, O. Svoboda., and E.
Angelopoulou, “Retinal vessel segmentation by improved
matched filtering: evaluation on a new high-resolution fundus
image database”, Image Processing, IET, Vol. 7, No. 4, pp.
373–383, June 2013.
[12] Ramakanth, S. Avinash, and R. Venkatesh Babu,
“Featurematch: A general ANNF estimation technique and its
applications”, IEEE Transactions on Image Processing, Vol.
23, No. 5, pp. 2193–2205, May 2014.
[13] S. A. Ramakanth and R. V. Babu, “Approximate nearest
neighbor field based optic disk detection”, Computerized
Medical Imaging and Graphics, Vol. 38, No. 1, pp. 49 – 56,
2014.
[14] H. Yu, E. Barriga, C. Agurto, S. Echegaray, M. Pattichis, W.
Bauman, and P. Soliz. , “Fast localization and segmentation of
optic disk in retinal images using directional matched filtering
and level sets”, IEEE Transactions on Information
Technology in Biomedicine, Vol. 16, No. 4, pp. 644–657,
2012.
[15] http://www.healthline.com/human-body-maps/retina

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Review on Optic Disc Localization Techniques

  • 1. International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169 Volume: 5 Issue: 10 54 – 58 _______________________________________________________________________________________________ 54 IJRITCC | October 2017, Available @ http://www.ijritcc.org _______________________________________________________________________________________ Review on Optic Disc Localization Techniques G.Jasmine PG Scholar Department of computer Science and Engineering V V College of Engineering Tisaiyanvilai, India jasminenesathebam@gmail.com Dr. S. Ebenezer Juliet M.E., Ph.D., Department of Computer Science and Engineering V V College of Engineering Tisaiyanvilai juliet_sehar@yahoo.com Abstract-The optic disc (OD) is one of the important part of the eye for detecting various diseases such as Diabetic Retinopathy and Glaucoma. The localization of optic disc is extremely important for determining hard exudates and lesions. Diagnosis of the disease can prevent people from vision loss. This paper analyzes various techniques which are proposed by different authors for the exact localization of optic disc to prevent vision loss. Keywords: Localization, Optic Disc (OD), Corner Detector, Vessel Convergence, Vessel Enhancement __________________________________________________*****_________________________________________________ I. INTRODUCTION The retina is thin layer of tissue, in which the blood vessels are clearly visualized. Its purpose is to receive the light and convert it to neural signals and these signals are send to the brain for the visual recognition [16]. The brightest region in the retinal image is the optic disc. The blood vessels originate from the center of optic disc. It is classified according to its size. The slit lamp examination is done with fundocopic lens from which vertical and horizontal disc diameter are obtained. The Optic disc cup increase in size with the disc size, where large cups are obtained in healthy eyes. It is also called as optic nerve head and blind spot [3]. Optic disc is not sensitive to light because of the absence of light sensitive rods and cone in the retina, so it is called as blind spot. Optic disc is located in the vessel convergence region. The localization of optic disc is done mainly to save people from vision loss. Fig 1. Optic Disc Optic disc is mainly used for detecting various diseases such as diabetic retinopathy and glaucoma. It can also be used for the detection of other anatomical structures such as macula and retinal vessels [10]. The major health problem that has increased recently is the Diabetic retinopathy. It is an asymptomatic disease which can lead to loss of vision. About 10,000 people lose their vision due to diabetic retinopathy. Retinal Treatment is the best method for reducing the vision loss. Regular eye examinations are required for detecting and treating the diabetic retinopathy [10]. The detection of optic disc in retinal image is very important for the exact localization of optic disc. To find the abnormal structures in the image it is to be mask out from the analysis. Optic disc detection is one of the important step for diabetic retinopathy and glaucoma for screening system. The optic disc boundary and the localization of macula is used for the detection of exudates and diabetic maculopathy. In diabetic maculopathy masking the false positive OD leads to improve in performance of lesion detection. The OD position is used as a reference length for measuring the distances in retinal images. The location of OD becomes the starting point for vessel tracking. Thus the optic disc localization is performed [4]. II. Techniques For Optic Disc Localization Optic disc localization is extremely important for determining the hard exudate lesions or nonvascularization. By localizing the optic disc, blindness can be reduced. To localize Optic Disc various methods are available. In this survey some of the methods are discussed below. 2.1 Approximate nearest neighbor field based optic disc detection A feature match ANNF algorithm Proposed in [14], to find the correspondence between the optic disc images. The correspondence between the images provides patches in the query image which are close to the reference image. This method uses only one retinal image which is used to extract the reference optic disc image. The given input image is preprocessed, in which reference optic disc is considered as an algorithm and the target image is considered as feature match. Then query image is preprocessed, i.e. it is equalized and converted to grayscale. ANNF searches the nearest patches
  • 2. International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169 Volume: 5 Issue: 10 54 – 58 _______________________________________________________________________________________________ 55 IJRITCC | October 2017, Available @ http://www.ijritcc.org _______________________________________________________________________________________ with low dimension, but it does not produce exact match. Accuracy is improved by using image coherency. The ANNF map point out the location of patches in query image which is same as of the reference image. Using these patches, the likelihood map (L) is computed. By using this L map the maximum location is find out to localize the optic disc. 2.2 Feature match: A general ANNF estimation technique and its Applications ANNF algorithm Proposed in [13], to estimate the mapping between image pairs. This generalization is achieved by spatial-range transforms and it enables to handle various vision applications, 1) optic disc detection- It mainly focus on medical images, for the localization of optic disc to produce as a target image. 2) super- resolution- It focus on synthetic images, which uses source image. The input is a reference image, which provides template for OD. It extracts the template from grayscale image, after histogram equalization. The optic disc which is extracted from the image forms a target image. The reference image is preprocessed as like query image. Likelihood map is initialized, to find the optic disc location in the image. After initialization of L map, it find out the number of times each patch is mapped in the query image. By using the L map it estimates the optic disc location. 2.3 Retinal vessel segmentation by improved matched filtering-evaluation on a new high-resolution fundus image database Segmentation of retinal vessels proposed in [12], to segment the blood vessels in the fundus images. The segmentation uses MF approach in the preprocessed image. The preprocessed image with five kernals, rotates into 12 orientations. The parametric image gets fused, so maximum responses are selected for each pixel. A blood vessel tree is obtained after threshold of fused image. The noise of the image structures are removed using morphological operators. A B-spline correction method is used to improve the accuracy of the proposed method. The two-dimensional MF exploits the correlation between image areas. The maximum response is selected from the set of parametric images for each pixel by using joint parametric image. The image is thresholded to obtain vascular tree. The blood vessels are considered as objects and remaining parts are considered as background of the image, where pixels inside the FOV are selected. The result of the thresholding algorithms are evaluated and compared using HRF database. Finally, morphological cleaning method is used to remove the artifacts, which are not connected to the vessel tree. 2.4 Teleophta: Machine learning and image processing methods for teleophthalmology Diabetic retinopathy screening proposed in[2], is done by using teleopthalmology screening, in which image deals with the normalization technique, which uses FOV photographs as size invariant. The parameters are defined based on the size. Then segmentation is done for border reflections. The reflections appear as bright and moon shaped regions. Then segmentation carried out. Then detection takes place and vessels are segmented and OD is detected and finally the macula. The vessel masks are analyzed to extract the structures. The detection starts with threshold to select bright regions as like optic disc. The vessel mask which is previously computed is used to select the correct position of the optic disc. An exudates detection method is developed for a heterogeneous database. The exudates regions are extracted by using the morphological opening operation method. Finally each exudate region of 30 characteristics is extracted for the purpose of training a random forest model. A random forest classifier is used to compute the risk of each exudates region. 2.5 Fast Localization and Segmentation of Optic Disc in Retinal Images Using Directional Matched Filtering and Level Sets The OD localization and segmentation algorithm proposed in [15], are used for the retinal disease screening. The OD locations are identified in the image using template matching. It is then designed to adapt various image resolutions. Then the patterns in OD determine the location. A hybrid levelset model is used to combine both the region and the local gradient information that is applied to the disc boundary segmentation. The blood vessels are removed using morphological filtering operation. The OD size can be calculated by FOV camera. Then the OD candidates are find out by using CIElab lightest image. Then the result is the normalized image. The optic disc candidates are selected according to the template responses. The segmentation uses morphological reconstruction to suppress the bright regions. At last the performance is evaluated by the combination of two test images. 2.6 Accurate and Efficient Optic Disc Detection and Segmentation by a Circular Transformation OD detection and segmentation technique proposed in [7], is used for the circular transformation, which captures the shape of the optic disc and variation in the optic disc boundary. First a retinal image is derived by combining both the red and green components it determines the intensity of the image. Then preprocessing takes place. According to the shape of the OD and the variation in the OD boundary the circular transformation is designed. Finally retinal image is converted to the OD map. Then optic disc is localized. 2.7 Automatic Optic Disc Detection from Retinal Images by a Line Operator An optic disc detection technique proposed in [8], is used to extract the lightness portion in the retinal image. The retinal images are preprocessed before the detection of optic disc. Then it is smoothed to enhance the brightest region associated with optic disc. Then the circular regions are detected using the line operator. The optic disc is located accurately using the orientation of the line segment. By using orientation map the optic disc is localized. The classification is done between the peak center and the surrounding of the peak center. By the combination of the peak amplitude and the image intensity the optic disc is detected. 2.8 Fast Localization of the Optic Disc Using Projection of Image Features Optic Disc brightness and retinal vessel orientations features proposed in [9], based on two projections of image features that encode x coordinate and y coordinate of the optic disc. The one dimension projections determine the location of optic disc. It avoids two dimension image space and it improves the speed of the localization process. For the localization of OD, the process gets split into two steps. First the horizontal location of OD is determined using the image features that are projected to the horizontal axis. In Second step it determines the correct vertical location. Assume, if horizontal location is successfully identified, then the only aim
  • 3. International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169 Volume: 5 Issue: 10 54 – 58 _______________________________________________________________________________________________ 56 IJRITCC | October 2017, Available @ http://www.ijritcc.org _______________________________________________________________________________________ is to find the correct vertical location. This can be found by feature_map_2 on the vertical axis. It is then find out as the maximum peak of the one dimensional signal. 2.9 Automated optic disc detection in retinal images of patients with diabetic retinopathy and risk of macular edema The optic disc detection proposed in [1], based on two methodologies. On one side it belongs to the image contrast and the structure filtering techniques optic disc location and on other side edge detection technique and Hough transform are used for the circular approximation of the optic disc. For the localization of optic disc there are three detection methods they are, 1) Maximum difference method- which provide the difference between the maximum and minimum calculation of the images using filter. 2) Maximum variance method- The maximum pixels are selected which are located in the brightest region. 3) Low pass filter method- It returns highest grey pixel. The OD boundary provides a circular approximation of optic disc using segmentation. The original retinography are extracted using the pixel in the optic disc. The coordinates are provided using localization methodologies, 1) The blood vessels are eliminated using dilation and smoothing are done using filter. 2) The gradient magnitude is obtained using prewitt operator. 3) The noise of the image is reduced using morphological erosion. 4) Finally circular approximation of optic disc is obtained using Hough transform. 2.10 Fast detection of the optic disc and fovea in color fundus photographs KNN regressor technique proposed in [11], used to predict the pixel distance, based on several features. The lowest distance in the fovea is selected as fovea location. First the image is preprocessed. Then the gradient magnitude is calculated by the detection of FOV in the red plane of the image. The optic disc and fovea localization uses green plane. The green plane image is blurred using a Gaussian filter to remove the low frequency gradients. The anatomical structure problems are defined as a regression problem. The goal is to find the dependent variable. The threshold is applied to get a vessel map. This method combines the cues that is measured directly and the segmentation of retinal vasculature. The optic disc center is selected according to the lowest predicted distance of optic disc. Using this, fovea is defined and it is selected as the fovea location in the fovea search area. 2.11Feature extraction in digital fundus images An exudate segmentation algorithm proposed in [5], used to enhance the exudates regions. First the image is preprocessed to improve the contrast of the lesions. Next optic disc is eliminated using entropy. A Fuzzy c-means clustering algorithm is used to extract the exudates regions. The FCM algorithm changes to standard FCM using spatial neighborhood information. Then vessel skeleton map is obtained. The neighbor pixels are obtained for each skeleton pixel. The vessels are detected by identifying the pixels with one neighbor vessel pixel. The disc boundary is detected using contour model. First image is preprocessed, then dilation carried out and OD boundary is determined. Then FCM algorithm is used to segment the exudates. Finally SVM classification is used to provide the exact lesion from non- lesion. TABLE 1: COMPARATIVE ANALYSIS OF OPTIC DISC LOCALIZATION TECHNIQUES PAPER TITLE ALGORITHMS/ METHODS FEATUR ES BENEFITS DRAWBACKS Approximate Nearest Neighbor Field based optic disc detection [14]  Optic Disc Location- Approximate Nearest Neighbour. Shape, Colour, Brightness  Performance is good.  Less computation time.  Less accuracy.  Dislocation of optic disc. Feature match: A general ANNF estimation technique and its Applications [13]  Feature Extraction- Walsh Hadamard Transformation.  K-NN Search- KD- tree algorithm. Colour, Gradient  Accuracy is good.  Coherency is good.  Regeneration of color information becomes a difficult problem.  Differences in image intensities. Retinal vessel segmentation by improved matched filtering-evaluation on a new high-resolution fundus image database [12]  Preprocessing- B- Spline- based illumination correction.  Correlation detection between images- 2D Match Filtering. Shape, Intensity  Reduces the false- positive detections.  High Resolution.  Poor Performance.  Evaluation is performed on low- resolution images. Teleophta: Machine learning and image processing methods for teleophthalmology [2]  Preprocessing- Field of View.  Anatomical detection- Morphological filter. Size, Shape, Contrast  Small vessels can be detected.  Help in rising of new population health challenges.  Lowers the specificity.  Poor Performance.
  • 4. International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169 Volume: 5 Issue: 10 54 – 58 _______________________________________________________________________________________________ 57 IJRITCC | October 2017, Available @ http://www.ijritcc.org _______________________________________________________________________________________ Fast Localization and Segmentation of Optic Disc in Retinal Images Using Directional Matched Filtering and Level Sets [15]  OD Size Estimation- Field Of View and image resolution.  OD Segmentation- morphological processing.  OD Localization- Template Matching. Size, Shape, Brightness  Increase robustness.  Accuracy of Optic Disc detection.  It is expensive.  Optic Disc detection is difficult. Accurate and Efficient Optic Disc Detection and Segmentation by a Circular Transformation [7]  Preprocessing- Down- Sampling.  OD Segmentation and Detection- B-Spline Filtering. Shape, Brightness  Algorithm runs faster.  Accuracy gets improved.  OD segmentation may introduce error.  Optic Disc boundary pixels cannot be determined based on symmetry. Automatic Optic Disc Detection from Retinal Images by a Line Operator [8]  Preprocessing- Bilateral smoothing Filter.  Circular Detection- Line Operator.  OD Detection- 2D Circular convolution Mask. Brightness, Image Variation  High Detection speed.  Retinal lesions can be tolerated.  Poor Performance.  Various types of imaging artifacts cannot be handled. Fast Localization of the Optic Disc Using Projection of Image Features [9]  OD Localization- Model based method. Space, Intensity  Less computation time.  Search-space dimensionality is reduced.  It is expensive.  Robustness for localization of OD is difficult. Automated OD detection in retinal images of patients with diabetic retinopathy and risk of macular edema [1]  OD Localization- Maximum difference and variance method, Low-pass filter method.  Segmentation of OD- Dilation, Prewitt operator, Erosion, Circular Hough Transform. Shape, Colour, Depth  Accuracy is increased.  Robustness is increased.  Poor Computation time.  High Megabytes images are not accepted. Fast detection of the optic disc and fovea in color fundus photographs [11]  Preprocessing- Field Of View.  Position Regression – Regression Size, Space  Performance is increased.  Increase in robustness.  Poor contrast.  Does not make strong assumption III. Conclusion This paper analyzes various techniques which are proposed by different authors for localizing the optic disc. Diabetic retinopathy leads to vision loss, where various preventive measures are taken to save people from vision loss. It focuses on the localization of optic disc. Various approaches are used for OD localization they are, Approximate Nearest Neighbour Field (ANNF), optic disc detection technique and Match filtering methods. These techniques are used to localize the exact optic disc. The performance is decreased due to optic disc dislocation. In future advanced algorithm can be used to improve the performance. REFERENCES [1] A. Aquino, M. E. Gegundez, and D. Marin, “Automated optic disc detection in retinal images of patients with diabetic retinopathy and risk of macular edema”, International Journal of Biological & Life Sciences, Vol. 8, No. 11, pp. 87, 2010. [2] E. Decencire, G. Cazuguel, X. Zhang, G. Thibault, J. C. Klein, F. Meyer, B. Marcotegui, G. Quellec, M. Lamard, R. Danno, D. Elie, P. Massin, Z. Viktor, A. Erginay, B. La, and A. Chabouis, “Teleophta: Machine learning and image processing methods for teleophthalmology”, fIRBMg, Vol. 34, No. 2, pp. 196 – 203, 2013. [3] Dehghani, Amin, Hamid Abrishami Moghaddam, and Mohammad-Shahram Moin, “Optic disc localization in retinal
  • 5. International Journal on Recent and Innovation Trends in Computing and Communication ISSN: 2321-8169 Volume: 5 Issue: 10 54 – 58 _______________________________________________________________________________________________ 58 IJRITCC | October 2017, Available @ http://www.ijritcc.org _______________________________________________________________________________________ images using histogram matching”, EURASIP Journal on Image and Video Processing, No. 1, pp. 1-11, 2012. [4] Godse, A. Deepali, and Dr. S. Dattatraya Bormane, “Automated localization of optic disc in retinal images”, (IJACSA) International Journal of Advanced Computer Science and Applications 4, No. 2, 2013. [5] G. B. Kande, P. V. Subbaiah, and T. S. Savithri, “Feature extraction in digital fundus images”, Journal of Medical and Biological Engineering, Vol. 9, No. 3, pp. 122–130, 2009. [6] S. Lu, “Accurate and efficient optic disc detection and segmentation by a circular transformation”, IEEE Transactions on Medical Imaging, Vol. 30, No. 12, pp. 2126– 2133, 2011. [7] S. Lu and J. H. Lim, “Automatic optic disc detection from retinal images by a line operator”, IEEE Transactions on Biomedical Engineering, Vol. 58, No. 1, pp. 88–94, 2011. [8] A. Mahfouz and A. Fahmy, “Fast localization of the optic disc using projection of image features”, IEEE Transactions on Image Processing, Vol. 19, No. 12, pp. 3285– 3289, 2010. [9] D. Michael, Abràmoff, K. Mona Garvin, Milan Sonka, “Retinal Imaging and Image Analysis”, IEEE Transactions on Medical Imaging 3, pp. 169-208, January 2010. [10] M. Niemeijer, M. D. Abrmoff, and B. Van Ginneken, “Fast detection of the optic disc and fovea in color fundus photographs”, Medical Image Analysis, Vol. 13, No. 6, pp. 859 – 870, 2009. [11] J. Odstrcilik, R. Kolar, A. Budai, J. Hornegger, J. Jan, J. Gazarek, T. Kubena, P. Cernosek, O. Svoboda., and E. Angelopoulou, “Retinal vessel segmentation by improved matched filtering: evaluation on a new high-resolution fundus image database”, Image Processing, IET, Vol. 7, No. 4, pp. 373–383, June 2013. [12] Ramakanth, S. Avinash, and R. Venkatesh Babu, “Featurematch: A general ANNF estimation technique and its applications”, IEEE Transactions on Image Processing, Vol. 23, No. 5, pp. 2193–2205, May 2014. [13] S. A. Ramakanth and R. V. Babu, “Approximate nearest neighbor field based optic disk detection”, Computerized Medical Imaging and Graphics, Vol. 38, No. 1, pp. 49 – 56, 2014. [14] H. Yu, E. Barriga, C. Agurto, S. Echegaray, M. Pattichis, W. Bauman, and P. Soliz. , “Fast localization and segmentation of optic disk in retinal images using directional matched filtering and level sets”, IEEE Transactions on Information Technology in Biomedicine, Vol. 16, No. 4, pp. 644–657, 2012. [15] http://www.healthline.com/human-body-maps/retina