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Understanding HYPERTENSION Reynel Dan L. Galicinao
Introduction
HYPERTENSION high BP intermittent or sustained elevation of diastolic or systolic blood pressure a disease of vascular regulation in which the mechanisms that control arterial pressure within the normal range are altered
Predominant mechanisms of control: ,[object Object]
renal pressor system (renin-angiotensin-aldosterone system)
extracellular fluid volumeThe basic explanation is that BP is elevated when there is increased cardiac output plus increased peripheral vascular resistance.
Classification
Hypertension is also classified according to its cause, severity, and type.  Two major types: ,[object Object]
Secondary hypertension - results from renal disease or another identifiable cause
Malignant hypertension - severe, fulminant form of hypertension that commonly arises from both types,[object Object]
The cause of essential hypertension is unknown.  Possible causes: ,[object Object]
Race
Stress
Obesity
Diet high in sodium or saturated fat
Use of tobacco or hormonal contraceptives
Excess alcohol intake
Sedentary lifestyle
Aging,[object Object]
Renal parenchymal disease
Pheochromocytoma
Primary hyperaldosteronism
Cushing's syndrome
Diabetes mellitus
Dysfunction of the thyroid, pituitary, or parathyroid gland
Coarctation of the aorta
Pregnancy
Neurologic disorder,[object Object]
Mineralocorticoids
Sympathomimetics
Cyclosporine
Cocaine
Epoetinalfa,[object Object]
Hypertension is a major cause of: ,[object Object]
Cardiac disease
Renal failureComplications occur late in the disease and can attack any organ system Cardiac complications: ,[object Object]
Angina
Myocardial infarction
Heart failure
Arrhythmias
Sudden death,[object Object]
hypertensive encephalopathyHypertensive retinopathy can cause blindness Renovascular hypertension can lead to renal failure
Clinical Manifestations
In many cases, the hypertensive patient has no symptoms The disorder is revealed incidentally during evaluation for another disorder or during a routine BP screening program When symptoms do occur, they reflect the effect of hypertension on the organ systems May cause headache, dizziness, blurred vision when greatly elevated
Diagnostic Evaluation
ECG ,[object Object],Chest X-ray  ,[object Object],Proteinuria, elevated serum blood urea nitrogen (BUN), creatinine levels ,[object Object]
first voided urine microalbumin or spot urine for albumin-creatinine ratio are earlier indicators,[object Object]

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