A comprehensive presentation on Metabolism of Zinc and its clinical significance for MBBS,BDS,B.Tech,B.Pharma and Biotechnology students for self-study.
8. Zinc Metabolism
vCauses of Zinc deficiency
a) Nephrotic syndrome
b) Hemolytic anemia ‘myocardial infarction’
c) Infection
d) Achrodermititis ( Zinc absorption defective )
vSymptoms of Zinc deficiency
a) Poor wound healing
b) Lesions in skin ( of mouth , nose ,fingers )
c) Spermatogenesis
d) Dermatitis/dementia / depression
e) Alopecia
11. Functions of Zinc
qFunctions of Zinc
1. for > 300 enzymes Zinc is a cofactor of enzymes ( LDH ,Alkaline phosphatase ,Carbonic
anhydrase , SOD , Carboxy peptidase )
2. RNA polymerase requires Zn for protein biosynthesis .
3. Extra cellular Super oxide dismutase is Zn dependent.
4. Zn –functions as an antioxidant.
5. synthesis of retinol binding protein require Zinc
6. Zinc required for immunological functions.
7. Zinc supplementation useful for treating acute diarrhea.
8. Zinc supplementation improves birth weight of babies.
9. Zinc plays important role in “ Insulin “ storage in beta pancreatic cells
10. ( commercial Protamine = Zinc insulate ) .
11. Gusten –Saliva taste sensation
12. Functions of Zinc –cofactor of RNA polymerase
RNA polymerase requires Zn for protein biosynthesis