2.
synthesized as a preprohormone (prorenin)
synthesized and stored in the juxtaglomerular
apparatus of the nephron
An important modulator of angiotensin production
RENIN
3.
Plays a key role in the regulation of
fluid and electrolyte balance
arterial blood pressure
Excessive activity can result in
hypertension
disorders of fluid and electrolyte homeostasis
ANGIOTENSIN II
5.
Kidney
increase proximal tubular sodium reabsorption
inhibit the secretion of renin
Actions
6. Central Nervous System
increase secretion of vasopressin
increase secretion of ACTH
Cell Growth
mitogenic for vascular and cardiac muscle cells
Actions
9.
CNS → neurotransmitter
GIT → transmitter in ENS and as a local hormone
Involved in behavior, anxiety, depression, nausea, and emesis
a potent arteriolar vasodilator
causes contraction of venous, intestinal, and bronchial
smooth muscle
stimulates secretion by the salivary glands
causes diuresis and natriuresis by the kidneys
SUBSTANCE P