Este documento presenta 3 diapositivas breves sobre el proceso de aprendizaje. La primera diapositiva indica que se está aprendiendo a hacer algo. La segunda continúa diciendo que el aprendizaje sigue. La tercera concluye expresando la esperanza de lograr lo que se está aprendiendo.
This autobiography describes the life of a woman born in 1989 in the Philippines. She had a happy childhood despite her father working abroad. She did well in school, graduating as an honor student from both elementary and high school. Unable to afford further education, she took a TESDA scholarship but had to stop studying to help support her family. She worked various jobs before finding stable work at an electronics company. She hopes to finish her college degree through another scholarship to become a teacher.
The document describes a wine tasting tour that included visiting several notable wineries in Napa Valley such as Mondavi, Cakebread, and Twomey, where they toured the vineyards, cellars, and tasting rooms, sampled different grapes and wines, and had a fun tasting amongst the redwoods at Korbel Vineyard.
1. A new study evaluated a compression device consisting of two thigh-level compression stockings and an interposed foam pad to increase interface pressures and reduce the diameter of the great saphenous vein.
2. The study measured interface pressures with and without the pad both standing and supine in 10 healthy subjects, finding pressures increased by 55% with the pad.
3. A CT scan with 3D reconstruction confirmed the pad reduced the diameter of the great saphenous vein by over 50% when used between two thigh compression stockings.
Syndrome metabolique et maladies vasculaires s novosfa_angeiologie
This document summarizes a presentation on detecting preclinical atherosclerosis and evaluating cardiovascular risk. It discusses the metabolic syndrome and its association with future cardiovascular events. The summary is:
1) The presentation discusses preclinical atherosclerosis, metabolic syndrome, and their ability to predict future cardiovascular events over long-term follow-up of patients.
2) Metabolic syndrome was found to double the risk of cardiovascular events over 20 years of follow-up compared to healthy patients.
3) Preclinical atherosclerosis detected by carotid ultrasound also independently predicted cardiovascular outcomes, with higher rates of events in patients showing thickening of carotid arteries.
Este documento presenta 3 diapositivas breves sobre el proceso de aprendizaje. La primera diapositiva indica que se está aprendiendo a hacer algo. La segunda continúa diciendo que el aprendizaje sigue. La tercera concluye expresando la esperanza de lograr lo que se está aprendiendo.
This autobiography describes the life of a woman born in 1989 in the Philippines. She had a happy childhood despite her father working abroad. She did well in school, graduating as an honor student from both elementary and high school. Unable to afford further education, she took a TESDA scholarship but had to stop studying to help support her family. She worked various jobs before finding stable work at an electronics company. She hopes to finish her college degree through another scholarship to become a teacher.
The document describes a wine tasting tour that included visiting several notable wineries in Napa Valley such as Mondavi, Cakebread, and Twomey, where they toured the vineyards, cellars, and tasting rooms, sampled different grapes and wines, and had a fun tasting amongst the redwoods at Korbel Vineyard.
1. A new study evaluated a compression device consisting of two thigh-level compression stockings and an interposed foam pad to increase interface pressures and reduce the diameter of the great saphenous vein.
2. The study measured interface pressures with and without the pad both standing and supine in 10 healthy subjects, finding pressures increased by 55% with the pad.
3. A CT scan with 3D reconstruction confirmed the pad reduced the diameter of the great saphenous vein by over 50% when used between two thigh compression stockings.
Syndrome metabolique et maladies vasculaires s novosfa_angeiologie
This document summarizes a presentation on detecting preclinical atherosclerosis and evaluating cardiovascular risk. It discusses the metabolic syndrome and its association with future cardiovascular events. The summary is:
1) The presentation discusses preclinical atherosclerosis, metabolic syndrome, and their ability to predict future cardiovascular events over long-term follow-up of patients.
2) Metabolic syndrome was found to double the risk of cardiovascular events over 20 years of follow-up compared to healthy patients.
3) Preclinical atherosclerosis detected by carotid ultrasound also independently predicted cardiovascular outcomes, with higher rates of events in patients showing thickening of carotid arteries.
To log into Blackboard, click "User Login" and enter your username as your first initial, last name followed by "_bb" and the temporary password "123456". Once logged in, your seminars will be listed and you can click on the seminar you want to access. Technical support is available to help change your password if desired.
This document contains lecture slides for CSE340 on intermediate code. It discusses instructions like LIT, LOD, STO, OPR, JMP, JMC and how they are used to represent code structures like while loops, if statements, and switch cases. It provides examples of translating source code to intermediate code and discusses using symbol tables and labels. It also assigns homework to translate a switch statement to intermediate code.
This document contains slides from a lecture on grammars and ambiguity given by Javier Gonzalez-Sanchez for CSE340 at ASU. It discusses how ambiguity arises from grammars having multiple parse trees for strings, and how layering rules can be used to make grammars unambiguous. Examples are provided of ambiguous and unambiguous grammars for arithmetic expressions. Later slides provide exercises for students to construct unambiguous grammars handling features like parentheses, variables, and multiple operators.
Lowering barriers to publishing biological data on the webBrad Chapman
Short 10 minute talk encouraging bioinformatics programmers to organize and reuse code targeted at making data easily available on the web. Current open source technologies are combined into a higher level framework. An example implementation using Google App Engine and existing bioinformatics libraries is presented.
The document summarizes the Rotary International theme for 2009-2010, which is "The Future of Rotary is in Your Hands". It discusses events from the Rotary Club of Makati including their first meeting where the guest speaker was PDG Jimmy Cura. It also mentions a fellowship mass and vocational road show. The bulletin board section excerpts a message from RI President John Kenny emphasizing that the future of Rotary lies with members in local clubs and their service, and asking members to focus on water, health, hunger and literacy.
The document discusses entrepreneurship and social entrepreneurship. It mentions the Euro-Med School and focuses on the Hub Milan, a community space for social entrepreneurs. It provides information about the Hub's locations over time, starting in 2005 in London and expanding to other cities. It discusses principles for starting a business, including focusing on ideas, products, teams, hiring, funding, and passion. The document promotes an entrepreneurial mindset and community support for social entrepreneurs.
The document discusses mobile learning (mLearning) using mobile devices to deliver interactive multimedia instruction. It outlines a project by researchers at Arizona State University to evaluate the impact of interactive tutoring and game-based environments on learning and engagement using mobile platforms. The document considers pros and cons of mLearning, compares it to eLearning, and proposes using scenarios and sensors in mobile devices to enhance learning experiences. The overall goal is to provide implications for developing effective mobile instruction.
The document outlines the details of a wedding ceremony and reception, including strands of lights and tealights in trees for the ceremony, a dress and bridesmaids for the bride, photography, invitations with calligraphy, programs, decorations with centerpieces possibly including artichokes and ferns, a cake and beverages, a mashed potato or grits bar for food, departure in a land rover or classic car with tin cans and birdseed, and favors such as turtles, recipe cards, coozies, and marshmallow bags for the overall theme.
The document summarizes Rotary activities in October 2009, including a district membership recruitment seminar, donations to charitable causes, and an event launching the 2010 Rotary International convention in Montreal. It also announces upcoming district events in November, including a forum with political candidates and the governor's visit to the local Rotary club.
Este documento es una carta de un amigo expresando su aprecio y admiración por el receptor. El autor dice que extraña al receptor cuando están lejos, se alegra cuando se ven o se comunican, y valora la amistad verdadera especialmente durante los malos momentos. Finalmente, el autor dice que el receptor es un gran amigo.
The document provides an overview of US income tax fundamentals, including:
1) Income taxes raise revenue and are used as social and economic policy tools;
2) Individuals file forms like 1040EZ, 1040A, or 1040 depending on filing status and income level;
3) Corporations and partnerships differ in that corporations pay corporate income tax while partnerships "pass through" items of income/loss to partners.
Introductory programming course have two very specific difficulties for novice students. First is the lack use of real world examples in the sessions. It is very difficult to find areas of application where all the students are familiar enough and that offers challenging and engaging examples. Second is the lack of palpable examples of the job done. Introductory courses in other fields generate products that the students can show to others, and feel proud about it. In CS1, for example, explaining cycles by printing a series of numbers on the screen doesn't yield the same sense of ac-complishment as drawing a basic perspective in an archi-tecture class. We propose using Project Hoshimi [1], a Microsoft Platform, as a base for introducing computer programming to CS1 students. Through the paper we dis-cuss the main advantages and disadvantages in our experi-ence of using Project Hoshimi, comparing its use against other more traditional approaches, as well as against other graphic programming methods such as Alice or videogame based learning.
To log into Blackboard, click "User Login" and enter your username as your first initial, last name followed by "_bb" and the temporary password "123456". Once logged in, your seminars will be listed and you can click on the seminar you want to access. Technical support is available to help change your password if desired.
This document contains lecture slides for CSE340 on intermediate code. It discusses instructions like LIT, LOD, STO, OPR, JMP, JMC and how they are used to represent code structures like while loops, if statements, and switch cases. It provides examples of translating source code to intermediate code and discusses using symbol tables and labels. It also assigns homework to translate a switch statement to intermediate code.
This document contains slides from a lecture on grammars and ambiguity given by Javier Gonzalez-Sanchez for CSE340 at ASU. It discusses how ambiguity arises from grammars having multiple parse trees for strings, and how layering rules can be used to make grammars unambiguous. Examples are provided of ambiguous and unambiguous grammars for arithmetic expressions. Later slides provide exercises for students to construct unambiguous grammars handling features like parentheses, variables, and multiple operators.
Lowering barriers to publishing biological data on the webBrad Chapman
Short 10 minute talk encouraging bioinformatics programmers to organize and reuse code targeted at making data easily available on the web. Current open source technologies are combined into a higher level framework. An example implementation using Google App Engine and existing bioinformatics libraries is presented.
The document summarizes the Rotary International theme for 2009-2010, which is "The Future of Rotary is in Your Hands". It discusses events from the Rotary Club of Makati including their first meeting where the guest speaker was PDG Jimmy Cura. It also mentions a fellowship mass and vocational road show. The bulletin board section excerpts a message from RI President John Kenny emphasizing that the future of Rotary lies with members in local clubs and their service, and asking members to focus on water, health, hunger and literacy.
The document discusses entrepreneurship and social entrepreneurship. It mentions the Euro-Med School and focuses on the Hub Milan, a community space for social entrepreneurs. It provides information about the Hub's locations over time, starting in 2005 in London and expanding to other cities. It discusses principles for starting a business, including focusing on ideas, products, teams, hiring, funding, and passion. The document promotes an entrepreneurial mindset and community support for social entrepreneurs.
The document discusses mobile learning (mLearning) using mobile devices to deliver interactive multimedia instruction. It outlines a project by researchers at Arizona State University to evaluate the impact of interactive tutoring and game-based environments on learning and engagement using mobile platforms. The document considers pros and cons of mLearning, compares it to eLearning, and proposes using scenarios and sensors in mobile devices to enhance learning experiences. The overall goal is to provide implications for developing effective mobile instruction.
The document outlines the details of a wedding ceremony and reception, including strands of lights and tealights in trees for the ceremony, a dress and bridesmaids for the bride, photography, invitations with calligraphy, programs, decorations with centerpieces possibly including artichokes and ferns, a cake and beverages, a mashed potato or grits bar for food, departure in a land rover or classic car with tin cans and birdseed, and favors such as turtles, recipe cards, coozies, and marshmallow bags for the overall theme.
The document summarizes Rotary activities in October 2009, including a district membership recruitment seminar, donations to charitable causes, and an event launching the 2010 Rotary International convention in Montreal. It also announces upcoming district events in November, including a forum with political candidates and the governor's visit to the local Rotary club.
Este documento es una carta de un amigo expresando su aprecio y admiración por el receptor. El autor dice que extraña al receptor cuando están lejos, se alegra cuando se ven o se comunican, y valora la amistad verdadera especialmente durante los malos momentos. Finalmente, el autor dice que el receptor es un gran amigo.
The document provides an overview of US income tax fundamentals, including:
1) Income taxes raise revenue and are used as social and economic policy tools;
2) Individuals file forms like 1040EZ, 1040A, or 1040 depending on filing status and income level;
3) Corporations and partnerships differ in that corporations pay corporate income tax while partnerships "pass through" items of income/loss to partners.
Introductory programming course have two very specific difficulties for novice students. First is the lack use of real world examples in the sessions. It is very difficult to find areas of application where all the students are familiar enough and that offers challenging and engaging examples. Second is the lack of palpable examples of the job done. Introductory courses in other fields generate products that the students can show to others, and feel proud about it. In CS1, for example, explaining cycles by printing a series of numbers on the screen doesn't yield the same sense of ac-complishment as drawing a basic perspective in an archi-tecture class. We propose using Project Hoshimi [1], a Microsoft Platform, as a base for introducing computer programming to CS1 students. Through the paper we dis-cuss the main advantages and disadvantages in our experi-ence of using Project Hoshimi, comparing its use against other more traditional approaches, as well as against other graphic programming methods such as Alice or videogame based learning.
The document discusses francophone seances for the 2014 JIFA conference. It lists the names N. Gaye, XL Modedero, V. Arfi, and M. Bouayed, suggesting they are presenters or participants. In 3 sentences or less, the summary provides a high-level overview of the topic and purpose while maintaining essential information from the original text.
This document summarizes several studies investigating the relationship between smoking and venous thromboembolism (VTE) risk. The studies found:
1) Current smoking was associated with a higher risk of VTE compared to never smokers, with a positive dose-response relationship. Former smokers had the same risk as never smokers.
2) Heavier smokers (>20 pack-years) had higher risks of total and provoked VTE compared to never smokers. The risk of provoked VTE increased with more pack-years of smoking.
3) The modestly increased risks of VTE in current or former women smokers were attenuated after adjusting for smoking-related diseases and decreased physical activity, suggesting an indirect relationship between smoking
1. Angiotensine, Endothélium,
maladies cardio-vasculaire &
AOMI:
Quelques rappels &
conséquences sur les choix thérapeutiques
• Bernard Saïag,
PU (H)
• Physiologie &
Physiopathologie
• Faculté de Médecine &
CHRU de Rennes
Fevrier 2013 SFA
2. Perméabilité Jonctions communicantes
&Transporteurs Canaux
Etat contractile Prolifération Hémostase
Muscles lisses. ..Epithéliums...Cardiomyocyte...Neurones...Cellules sanguines...
Muscles squelettiques
EDHF NO° PGI2 Purines Autres
Endothéline
PATHOLOGIES
(vasospasmes, ACTIVITE PHYSIQUE
HTA,
athérosclérose...) Cellule endothéliale
Cellules PATHOLOGIES
tumorales (insuffisance cardiaque, ischémie,...)
& autres?
Ach Thr
Hypoxie
AII ATP Shear
BK UTP -Ad stress FACTEURS ENVIRONNEMENTAUX
( pollution, tabac, médicaments potentiels,..
Angiogenèse
& processus associés
ENDOTHELIUM ET INTERACTIONS FONCTIONNELLES
Journées Internationales d ’Angéiologie, Palais des Congrès, Paris, 24 et 25 Janvier 2003 Bernard Saïag
3. Vasodilatation endothélium-dépendante
hyperpolarization
RELAXATION
vascular
+ smooth
GCs GMPc
Heme muscle
AMPc cell
Myoglob. +
N GTP
P2Y P1
NO
K+
NO
{EDRF}
ADP
ADP
AD
AD
PGI2
PGI2
{EDRF} ATP
EDHF
EDHF ATP
NADPH
+ endothelial
NO cell
02
L Citrulline L arginine PGI2
+
CYCLOOXYG.
EDHF NO synthase
PGI
+ ATP
2
N NO
AA
Ca-calmoduline
Ca ++
P2Y PGI Thr P2u M1 H1 AII
M1 M2 BK α2 H1 SP Thr 5HT V 2 P2Y BK
P2U PYR
subs.P
subs.P shear stress
shear Ach
Ach NA
NA ATP 5HT
5HT AVP
AVP Thr
Thr ADP
ADP UTP
UTP Ach. BK
Ach. BK H
H AII
AII
shear ATP Thrombine
Thrombine
stress Adr Histamine
Adr Histamine ADP
-
stress BradyKinine ADP ANF
ANF
BradyKinine UTP
UTP •Ad TGFß
TGFß
A23187
A23187
platelets
platelets AGREGGATION neutrophil
Shear
stress
vessel
stretch
Bernard Saïag Journées Internationales d ’Angéiologie, Palais des Congrès, Paris, 24 et 25 Janvier 2003
P2Y
4. Vasoconstriction endothélium-dépendante
contraction
relaxation
ET
P2U -P2X- PYR contraction
contraction vascular
smooth
muscle cell
ET
basal Mb
ATP and UTP endothel ial
release cell
+
EDCF2 or TxA 2 (?) or PGH 2
(?)
(o 2 °?)
NO EDCF2 endothelin (EDCF )
1
PAF ?
AII
PGI2
proendotheline
EC α2 M 1-2 5HT 5HT P2Y α2 P2Y 5HT AII Thr M1-2
AII 5HT ADP Hypoxia Ach
A23187 stretch NA 5HT AII
Ach ADP
AI Adr. thrombine TXA2
arachidonic
NA 5HT
Ac.
shear stress +
Adr. + PGD2
coagulation
agreggation platelets
Bernard Saïag
•Journées Internationales d ’Angéiologie, Palais des Congrès, Paris, 24 et 25 Janvier 2003
5. L'Enzyme de Conversion
L'enzyme de conversion (EC): - catalyse la
transformation de l'Angio I --> Angio II -
mais c'est aussi la bradykininase II, une des
enzymes catabolisant la bradykinine en
peptides inactifs. Rôle de la bradykinine :
--> natriurèse, --> vasodilatation par
augmentation EDRF --> production de
prostaglandines vasodilatatrices PGE2 et
PGI
7. Prise en charge médicamenteuse & AOMI
– AntiAgrégant Plaquettaire
• Aspirine (75 - 160 mg/j)
– Prévention cardiovasc 2° (RR 0,81) (ATC) mais pas d’évaluation dans l’AOMI
• ou clopidogrel 75 mg/j
– Statine
• simvastatine 40 mg vs placebo (essai HPS)
• Diminution de la mortalité globale (RR 0,87) et vasc (RR 0,76) chez
des
patients à très haut risque
• même dans l’absence de dyslipidémie
– IEC
• ramipril 10 mg vs placebo (essai HOPE) par paliers (2 à 4 semaines)
• Diminution de la morbi mortalité cardiovasc chez les patient atteints
d’AOMI (RR 0,78)
• même dans l’absence de HTA
– L’ AOMI n’est pas une contre indication aux betabloquants
8. Les différents IEC
énalapril : RENITEC°
lisinopril : ZESTRIL° cp à 5 et 20 mg ,
ramipril : TRIATEC° cp à 1,25, 2,5 et 5 mg
périndopril : COVERSYL°; quinapril :
ACUITEL° - KOREC°; bénazepril :
CIBACENE° BRIEM°; trandolapril :
GOPTEN° ODRIK gélules à 0,5 - 2 mg;
cilazapril : JUSTOR°cp à 0,5 , 1 , 2,5 mg;
fosinopril : FOZITEC° cp à 10mg, sécables, et
20 mg ; moexipril : MOEX° cp à 7,5 et 15 mg;
imidapril : TANATRIL° cp à 5 et 10 mg
9. Mécanisme d'action des IEC
Les IEC bloquent l'enzyme de conversion
de l'angiotensine, ce qui entraîne: - une
réduction de la formation d'angiotensine II -
une diminution de la dégradation de
bradykinine et une accumulation de celle-ci
- une augmentation de la production de
rénine
10. Effets indésirables des IEC
-Impliquants l'arrêt du traitement-
• Insuffisance rénale en cas de sténose de
l'artère rénale
• Hypotension artérielle (risque de
vertiges)
• Angio-oedème (rare -<1% mais grave)
• Hyperkaliémie (si insuffisance rénale)
• Toux (due à non dégradation de la
Bradykinine)
11. Suivi biologique de ces traitements pharmacologiques
.kaliémie, créatininémie en surveillance du traitement par
IEC ou antagoniste du récepteur de l’angiotensine 2
(ARA2)
. dosage des transaminases en début de traitement par
statine
. dosage des créatine phosphokinase (CPK) en cas
d’apparition de
symptômes musculaires inexpliqués, Inter national
Nor malized Ratio (INR) dans le cas de traitement par
antivitamine K].
NB: Surveiller la pression arterielle
En cas de coronaropathie, l’AOMI au stade d’ischémie d’effort ne
contre-indique pas les bêtabloquants.
12. Reférence
Expert consensus document on angiotensin converting
.
enzyme inhibitors in cardiovascular disease ; European
Society of Cardiology. European Heart Journal (2004)
25, 1454-70
. Nony P, Boissel JP. Les traitements médicamenteux
dans l'artériopathie chronique oblitérante des
membres inférieurs. Données factuelles 2006.
Médecine. 2006;2:153-7.
. Nony P. AOMI& traitements médicamenteux
compatibles avec un bénéfice clinique: anticoagulants,
hypocholestérolémiants et IEC. Médecine 2006, 2, 5,
201-204