Official Copy

1. ADENOVIRUS Maria Ellery M. Mendez, MD, DPASMAP, FPAMS, FPAAAMI Department of Microbiology Our Lady of Fatima University

15. CLINICAL FINDINGS EYE INFECTIONS

20. TREATMENT No specific treatment for adenovirus infections

21. PAPOVAVIRUSES

28. PATHOGENESIS Squamous epithelium of skin (warts) & mucous membrane (genital, oral & conjunctival) (+) epithelial proliferation Hand, foot, throat, eyes, cervix Local multiplication Resolution (latency) Cell transformation

32. CLINICAL Association of HPV with Clinical Lesions HPV TYPE CLINICAL LESION SUSPECTED ONCOGENIC POTENTIAL 1, 4 Plantar warts Benign 2,4,26,27,29 Common warts Benign 3,10,28,41 Flat warts Rarely malignant 5,8 Epidermodysplasia verruciformis in patients w/ CMI deficiency 30% progress to malignancy 6,11 Anogenital condylomas; laryngeal papillomas; dysplasias and intraepithelial neoplasias Low

33. CLINICAL HPV TYPE CLINICAL LESION ONCOGENIC POTENTIAL 7 Hand warts of meat and animal handlers Benign 9,12,14,15,17,19-25, 36,46,47 Epidermodysplasia verruciformis Some progress to CA (eg, HPV-17, HPV-20) 13, 32 Oral focal epithelial hyperplasia Possible progression to CA 16,18,30,31,33 35,39,45,51,52 56 High-grade dysplasias & CA of genital mucosa; laryngeal & esophageal CA High correlation with genital & oral CA 34,40,42-44, 53-55, 58, 59, 61,62,64 66-69 Intraepithelial neoplasias (genital, other mucosal sites) Some progress to CA 75,77 Common warts in organ transplant patients 37 Keratoacanthoma Benign

34. CLINICAL COMMON WART

35. CLINICAL FLAT WARTS

36. CLINICAL PLANTAR WARTS

37. CLINICAL MULTIPLE WARTS SUBUNGUAL WART

38. CLINICAL LABIAL CONDYLOMA

39. CLINICAL INTERGLUTEAL CONDYLOMA

45. PATHOGENESIS INHALATION Multiplication in RT Primary viremia KIDNEYS Transient secondary viremia IMMUNOCOMPETENT IMMUNODEFICIENT Latent indefinitely in kidney BK virus – urinary tract Hemorrhagic cystitis JC virus – CNS PML

49. PARVOVIRUS

54. PATHOGENESIS Virus in URT Local replication Viral replication in erythroid precursor cells in BM Viremia Rash & arthralgia (erythema infectiosum) Normal host (slight drop in hemoglobin) Host with chronic hemolytic anemia Aplastic crisis

57. CLINICAL