1. Waleed K.O. Jaber

2. Def.:
Thrombosis is the
formation of a blood
clot inside a blood
vessel or the heart,
which can partially or
completely obstruct
the flow of blood. The
blood clot itself is
referred to as a
THROMBUS.

3. Coagulation:
In medicine, the clotting of blood. The process
by which the blood clots to form solid masses, or
clots.
# More than 30 types of cells and substances in
blood affect clotting. The process is initiated by
blood Platelets. Platelets produce a substance
that combines with calcium ions in the blood to
form thromboplastin, which in turn converts the
Protein Prethrompin into Thrombin in a
complex series of reactions. Thrombin, a
proteolytic enzyme, converts Fibrinogen, a
protein substance, into fibrin, an insoluble
protein that forms an intricate network of
minute threadlike structures called fibrils and
causes the blood plasma to gel. The blood cells
and plasma are enmeshed in the network of
fibrils to form the clot.

4. Causes:
 The composition of the blood (hypercoagulability or
thrombophilia)
 Quality of the vessel wall (endothelial cell injury)
 Nature of the blood flow (stasis, turbulence)

5. Classification:
 Venous thrombosis:
 Deep vein thrombosis

6. • Portal vein thrombosis
(affecting the hepatic portal vein )
portal hypertension & blood supply to the
liver.

7.  Renal vein thrombosis (obstruction of the renal
vein )

8.  Jugular vein thrombosis

9.  Arterial thrombosis :
 Stroke

10.  Myocardial infarction :

12. A myocardial infarction occurs when an
atherosclerotic plaque slowly builds up in
the inner lining of a coronary artery and then
suddenly ruptures, causing catastrophic
thrombus formation, totally occluding the artery
and preventing blood flow downstream.

13. Drawing of the heart showing
anterior left ventricle wall
infarction