Aung citt nyein

M.V. LOMONOSOV MOSCOW STATE UNIVERSITY FACULTY OF BASIC MEDICINE Complex Combination Biochemotherapy In Advanced Metastatic Melanoma Dr. Aung Citt Nyein (M.B.,B.S) Scientific Supervisor: Prof. Dr. Lev Demidov N.N. BLOKHIN CANCER RESEARCH CENTRE MOSCOW, 2010 N.N. BLOKHIN CANCER RESEARCH CENTRE

INTRODUCTION ,[object Object],[object Object],[object Object]

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AIM OF STUDY ,[object Object],[object Object],[object Object],[object Object]

RESEARCH OBJECTIVES ,[object Object],[object Object],[object Object]

RISK FACTORS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CHARACTERISTICS OF MELANOMA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Superficial Spreading Melanoma

TREATMENT REGIMENS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Material and Methods ,[object Object],[object Object],Regimen Treatment Schedule DTIC 850 mg / m² iv , day 1 Vindesine 1.6 mg / m² iv , days 1-5 Cisplatin 20 mg / m² iv , days 2-5 Interleukin-2 9 MU / m² iv , days 1-5 Interferon- α 2b 5 MU IE sc , days 1-5

Patients Characteristics (No. of organ affected)

Patients Characteristics (Previous Therapy)

Tumour response to therapy CR -complete remission : PR -partial remission : SD -stable disease : PD -disease progression

Toxicities of Chemo and Immunotherapeutic Agents Toxic Effects

Dosage reduction for each of the chemo and Immunotherapeutics Agents Reduction Rate

CONCLUSION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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