Clinical, Forensic, Environmental and Industrial Toxicology Service

1. Toxicological Risk Assessment
An initiative of
24 October 2013 - UCL - Brussels (Woluwe)
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2. Clinical, Forensic, Environmental
and Industrial Toxicology Service
Prof. Corinne CHARLIER
University of Liège – CHU Sart Tilman
Dr Raphaël DENOOZ
Head of Laboratory
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3. Fields of expertise and industrial targets
Fields of expertise
• Therapeutic drug monitoring of conventionally and non•
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conventionally measured drugs
Pharmacokinetic studies for drugs of abuse
Influence of endocrine disruptors on hormonal pathologies
Markers of genetic susceptibility in industrial toxicology
Oxidative stress
Industrial applications fields
• Drug administration and pharmaco-kinetics
• Clinical toxicological studies
• Risk assessment
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4. Special equipments
Examples
• High-performance liquid chromatography with photodiode
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array detection (3)
High-performance liquid chromatography with fluometric
detection (1)
Ultra-performance liquid chromatography with photodiode
array and fluometric detection (1)
Ultra-performance liquid chromatography tandem mass
spectrometry (1)
High resolution liquid chromatography mass spectrometer (1)
Gas chromatography coupled to tandem mass spectrometry (3)
Inductively coupled plasma mass spectrometry (2), with
collision reaction cell (1)
FIMS – Flow Injection Mercury Systems (1)
Very large and competitive equipment
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5. Applied research projects
Therapeutic Drug Monitoring
• B-lactam drugs (Cefepim, Cefuroxim, Ceftazidim, Meropenem,
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Piperacilline)
Antifungal drugs (Ketoconazole, Itraconazole, Posaconazole,
voriconazole)
Antineoplastic agents (Imatinib, Nilotinib)
Antiparasitic drugs (Albendazole)
Epidemiology
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Phtalates, Parabens and Benzophenone-3
Bisphenol A, Triclosan and Nonylphenol
Heavy metals (Cadmium, Arsenic, Mercury, Lead, …)
PCB and organochlorine compounds
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6. Services provided to companies
Examples
• Critical analysis of toxicological data before drug
registration
• Toxicokinetic or pharmacokinetic studies
• Risk assessment for any type of chemical pollutants
• REACH
(Registration, Evaluation, Authorization and Restriction of
Chemical – Human Toxicology)
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7. Training proposals to companies
• All separative methods applied to drugs or chemical
products in biological samples (UPLC-HRMS, GC-MS/MS)
• Validation of analytical methods following international
criteria (FDA, …)
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Accreditation processes following iso 17025 or
15189
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8. Contacts
University of Liège – CHU Sart Tilman
Clinical, Forensic, Environmental and Industrial Toxicology
Service
Domaine universitaire du Sart-Tilman – Bâtiment B35
www.chuliege.be/toxicologie
Prof. Corinne CHARLIER
Head of Service
c.charlier@chu.ulg.ac.be
 +32 43 66 76 83
Phn Virginie MISTRETTA
Head of Laboratory
VI.Mistretta@chu.ulg.ac.be
 +32 43 66 76 83
Dr Raphaël DENOOZ
Head of Laboratory
Raphael.Denooz@chu.ulg.ac.be  +32 43 66 88 16
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