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Entretiens Vasculaires de Québec 2014
G.Nourissat MD
Context
2
Context/90’: Outcomes of bypass
surgery
Dalman, RL, Taylor, LM Jr. Infrainguinal revascularization procedures. In: Basic
Data Underlying Clinical Decision Making in Vascular Surgery, Porter, JM, Taylor,
LM, Jr (Eds), Quality Medical Publishing, St. Louis 1994. p.141.
3
P. Patency AK 1 year FU 4 y FU
Saphenous 84% 69%
PTFE 79% 60%
BK 1 year FU 4 y FU
C.P.Patency 90% 75%
S.Patency PTFE 68% 40%
Context/2005
4
RECOMMENDATIONS
Class I
1 Bypasses to the above-knee popliteal artery should be constructed with autogenous saphenous vein when possible. (Level of
Evidence: A)
2 Bypasses to the below-knee popliteal artery should be constructed with autogenous vein when possible. (Level of Evidence: A)
3 The most distal artery with continuous flow from above and without a stenosis greater than 20% should be used as the point of
origin for a distal bypass. (Level of Evidence: B)
4 The tibial or pedal artery that is capable of providing continuous and uncompromised outflow to the foot should be used as the site
of distal anastomosis. (Level of Evidence: B)
5 Femoral-tibial artery bypasses should be constructed with autogenous vein, including the ipsilateral greater saphenous vein, or if
unavailable, other sources of vein from the leg or arm. (Level of Edence:B)
6 Composite sequential femoropopliteal-tibial bypass and bypass to an isolated popliteal arterial segment that has collateral outflow
to the foot are both acceptable methods of revascularization and should be considered when no other form of bypass with adequate
autogenous conduit is possible. (Level of Evidence: B)
7 If no autogenous vein is available, a prosthetic femoral-tibial bypass, and possibly an adjunctive procedure, such as arteriovenous
fistula or vein interposition or cuff, should be used when amputation is imminent. (Level of Evidence: B)
Class IIa
1 Prosthetic material can be used effectively for bypasses to the below-knee popliteal artery when no autogenous vein from ipsilateral
or contralateral leg or arms is available. (Level of Evidence: B)
Context/2007
5
Context: BASIL / 2005
6
What about latest outcomes in
literature?
7
2012/ ssGSV bypass
8
n=1100 ssGVS aaVG
1 year 3 years 1 year 3 years
PP 74.4% 67.1% 53.7% 42% p<0.0001
aPP 82.8% 78.2% 67.2% 57.8% p<0.0001
SP 84.8% 80.8% 69.9% 61.4% p<0.0001
LS 88.9% 86.9% 83% 77.2% p<0.0001
2005/Outcomes of bypass
surgery: alternate conduit
9
SP LS
2008/ perigeniculate bypass
10
Limb salvage :90,2% (3 years)
Survival 63,9% (3 years)
— Primary patency
--- Assisted primary patency
Primary patency 65,7%
(3 ans)
2014/Outcomes of bypass
surgery: angiosomal concept
Limb Salvage 1 year 3 year 5 year
Angiosomal group 91% 65% 58%
Indirect group 66% 24% 18%
11
P<0.001
2010/ Outcomes of infragenicular
bypass
5 years
follow-up
N= 1023 Leg salvage Survival Freedom
from surgical
revasc.
PTA 262 75.3% 47.5% 85.3%
Bypass 761 76% 43.3% 91.4%
p< 0.001
12
BASIL / 2010
13
2011/ Outcomes of surgery
bypass and comorbities
14
EBM with endovascular therapy
approach first?
 Tasc II= level C
 Guidelines 2013* AHA = level B
 Meta-analyse Jens 2014**= level C
15
*2013/ Management of Patients With Peripheral Artery Disease (Compilation of 2005 and 2011
ACCF/AHA Guideline Recommendations) A Report of the American College of Cardiology
Foundation/American Heart Association Task Force on Practice Guide
Developed in Collaboration With the Society for Cardiovascular Angiography and Interventions, So
of Interventional Radiology, Society for Vascular Medicine, and Society for Vascular Surgery
**Randomized Trials for Endovascular Treatment of Infrainguinal Arterial Disease: Systematic
Review and Meta-analysis (Part 2: Below the Knee).
Jens S1, Conijn AP2, Koelemay MJ2, Bipat S3, Reekers JA3.
Eur J Vasc Endovasc Surg. 2014 May
Bypass indication in 2014
?
 Anatomic TASC D lesion +/- B or C
 Autogenous veins suitable
 Life expectancy > 2years*
 PTA failure/ Restenosis =Not anymore!?
 Trained center
 Target angiosomal zone respected
16
*2013/ Management of Patients With Peripheral Artery Disease (Compilation of 2005 and 2011 ACCF/AHA Guideline Recommen
A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Gu
Developed in Collaboration With the Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology,
for Vascular Medicine, and Society for Vascular Surgery
Bypass indication in 2014 ?
 BEST-CLI-Trial
17
Merci
18

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2014session2 2

  • 1. Entretiens Vasculaires de Québec 2014 G.Nourissat MD
  • 3. Context/90’: Outcomes of bypass surgery Dalman, RL, Taylor, LM Jr. Infrainguinal revascularization procedures. In: Basic Data Underlying Clinical Decision Making in Vascular Surgery, Porter, JM, Taylor, LM, Jr (Eds), Quality Medical Publishing, St. Louis 1994. p.141. 3 P. Patency AK 1 year FU 4 y FU Saphenous 84% 69% PTFE 79% 60% BK 1 year FU 4 y FU C.P.Patency 90% 75% S.Patency PTFE 68% 40%
  • 4. Context/2005 4 RECOMMENDATIONS Class I 1 Bypasses to the above-knee popliteal artery should be constructed with autogenous saphenous vein when possible. (Level of Evidence: A) 2 Bypasses to the below-knee popliteal artery should be constructed with autogenous vein when possible. (Level of Evidence: A) 3 The most distal artery with continuous flow from above and without a stenosis greater than 20% should be used as the point of origin for a distal bypass. (Level of Evidence: B) 4 The tibial or pedal artery that is capable of providing continuous and uncompromised outflow to the foot should be used as the site of distal anastomosis. (Level of Evidence: B) 5 Femoral-tibial artery bypasses should be constructed with autogenous vein, including the ipsilateral greater saphenous vein, or if unavailable, other sources of vein from the leg or arm. (Level of Edence:B) 6 Composite sequential femoropopliteal-tibial bypass and bypass to an isolated popliteal arterial segment that has collateral outflow to the foot are both acceptable methods of revascularization and should be considered when no other form of bypass with adequate autogenous conduit is possible. (Level of Evidence: B) 7 If no autogenous vein is available, a prosthetic femoral-tibial bypass, and possibly an adjunctive procedure, such as arteriovenous fistula or vein interposition or cuff, should be used when amputation is imminent. (Level of Evidence: B) Class IIa 1 Prosthetic material can be used effectively for bypasses to the below-knee popliteal artery when no autogenous vein from ipsilateral or contralateral leg or arms is available. (Level of Evidence: B)
  • 7. What about latest outcomes in literature? 7
  • 8. 2012/ ssGSV bypass 8 n=1100 ssGVS aaVG 1 year 3 years 1 year 3 years PP 74.4% 67.1% 53.7% 42% p<0.0001 aPP 82.8% 78.2% 67.2% 57.8% p<0.0001 SP 84.8% 80.8% 69.9% 61.4% p<0.0001 LS 88.9% 86.9% 83% 77.2% p<0.0001
  • 9. 2005/Outcomes of bypass surgery: alternate conduit 9 SP LS
  • 10. 2008/ perigeniculate bypass 10 Limb salvage :90,2% (3 years) Survival 63,9% (3 years) — Primary patency --- Assisted primary patency Primary patency 65,7% (3 ans)
  • 11. 2014/Outcomes of bypass surgery: angiosomal concept Limb Salvage 1 year 3 year 5 year Angiosomal group 91% 65% 58% Indirect group 66% 24% 18% 11 P<0.001
  • 12. 2010/ Outcomes of infragenicular bypass 5 years follow-up N= 1023 Leg salvage Survival Freedom from surgical revasc. PTA 262 75.3% 47.5% 85.3% Bypass 761 76% 43.3% 91.4% p< 0.001 12
  • 14. 2011/ Outcomes of surgery bypass and comorbities 14
  • 15. EBM with endovascular therapy approach first?  Tasc II= level C  Guidelines 2013* AHA = level B  Meta-analyse Jens 2014**= level C 15 *2013/ Management of Patients With Peripheral Artery Disease (Compilation of 2005 and 2011 ACCF/AHA Guideline Recommendations) A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guide Developed in Collaboration With the Society for Cardiovascular Angiography and Interventions, So of Interventional Radiology, Society for Vascular Medicine, and Society for Vascular Surgery **Randomized Trials for Endovascular Treatment of Infrainguinal Arterial Disease: Systematic Review and Meta-analysis (Part 2: Below the Knee). Jens S1, Conijn AP2, Koelemay MJ2, Bipat S3, Reekers JA3. Eur J Vasc Endovasc Surg. 2014 May
  • 16. Bypass indication in 2014 ?  Anatomic TASC D lesion +/- B or C  Autogenous veins suitable  Life expectancy > 2years*  PTA failure/ Restenosis =Not anymore!?  Trained center  Target angiosomal zone respected 16 *2013/ Management of Patients With Peripheral Artery Disease (Compilation of 2005 and 2011 ACCF/AHA Guideline Recommen A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Gu Developed in Collaboration With the Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, for Vascular Medicine, and Society for Vascular Surgery
  • 17. Bypass indication in 2014 ?  BEST-CLI-Trial 17

Editor's Notes

  1. Dans la décision de réaliser un pontage intervient de façon majeur mais souvent arbitraire la classe fonctionnelle, les comorbidités et l’âge du patient. Les allemands ont publier dans les annales en 2011 un travail intéressant sur l’influence des comorbidités et de l’âge du patient dans les résultats des revacsularisations chirurgicales infragéniculées pour ischémie critiques. Il s’agit d’une enquête retrospective sur 10 an par la même équipes N=624 avec des lésions TASC C ou D Revascualrisés par pontages veineux exclusivement Critére de comorbidité: MCAS, Insuff. Rénale, diabéte, age, sexe Résultat sur le taux de sauvetage de membre: -amputation précoce (à 30 jours): 7% …MCAS, age, Insuff renale et sexe n’influence pas le taux d’amputation précoce -sauvetage de membre à long terme: 66,4% … et pas influencé par le MCAS, le diabète, , insuff rénale, age et sexe Résultat sur la survie: -précoce (à 30jours): mortalité=5% …pas influencé par MCAS, Diabete, sexe … et influencé de manière significative par age (octagénaire) et insuffisance rénale -espérance de vie: MCAS, insuff rénale et age > 70 ans reduisent significativement l’espérance de vie Conclusion de l’étude: Les comorbidités et l’âge avancé réduisent de manière significative l’espérance de vie mais n’ont pas d’influence sur le taux de sauvetage de membre à long terme. Un an auparavant dans le British Journal of Surgery, les Finlandait offraient leur résultats sur une cohorte d’octagénère N=580 Plus de 80ans Comparer les résultats dilat versus pontage chez les patients en CLI Meilleurs résultats à 2 ans dans le bras PTA, cf tableau Significativement meilleur dans la survie et le sauvetage de membre Notamment dans la survie sans amputation a 1an chez les patient porteur d’une MCAS Conclusions; Lorsque faisable la stratégie de PTA en premier semble meilleurs résultats que les pontages infragéniculés chez le patient de 80 ans ou plus
  2. En conclusion, -nous pensons que les revascularisations par pontage semblent conserver une place majeurs dans le traitement de le traitement de l’ischémies critiques en 2014. -seul les revascularisations par pontages sont capables a ce jour d’offrir des résultats efficient à long termes c’est à dire avec un niveau de preuve élevé et des résultats à 5 ans pou plus . Restez vigilant de ne pas tomber dans la » facilité » de la revascularisation endovasculaire d’emblée et exclusive. Les indications sont probablement encore en train de se clarifier, mais qu’il existe très certainement des indications de pontage de premier intention. Qu’il est fondamental d’apprendre les chirurgiens vasculaires en formation les techniques endovasculaire de dernier cri mais aussi la réalisation des pontages périphérique et infragéniculé!
  3. Best Endovascular versus best Surgical Therapy in Patients with Critical Limb Ischemia Objectif: comparer le taux d,amputation free survival chez des patients randomisés open versus EVT Prospectif, randomisé open; versus endovascular treatment 2 cohortes seront comparées: 1)evt versus open patients with an available single segment great saphenous vein 2) evt versus open patients without a SSGSV