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L'art au centre 11.16.2004
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Human obesity is strongly associated with cardio metabolic disease. Cystatin C is a naturally occurring protease inhibitor and marker of cardiovascular disease. The main objective of present study was to estimate the serum levels of Cystatin C in individuals with normal BMI, and obese, aged between 18-39 Yrs and to compare the levels of serum Cystatin C among these individuals and to correlate the levels of serum Cystatin C with cardio metabolic risk factors. Material & Methods: The study population was taken from healthy volunteers of Mysore city, aged between 18- 39 years of either sex. The study population was divided into 2 groups based on BMI. Each group contains sample size of 45. Fasting serum sample was analyzed for Blood glucose, Total cholesterol, Total Triglycerides, Direct HDL cholesterol, Direct LDL Cholesterol by enzymatic method and serum Cystatin-C by immunoturbidimetric method using auto analyser. Results: The serum Cystatin C levels was significantly increased in obese groups, p value<0.001. The mean serum Cystatin C levels in normal BMI group was 0.78±0.03, and in Obese group is 1.15±0.09. In the study serum Cystatin C showed a positive correlation with serum glucose(r=0.61) serum triglycerides (r=0.7), Atherogenic index of plasma (AIP) (r=0.80), TCHOL: HDL (r=0.71), HDL: LDL (r=0.70) respectively and negative correlation with serum HDL (r=-0.52)
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iosrjce
Human obesity is strongly associated with cardio metabolic disease. Cystatin C is a naturally occurring protease inhibitor and marker of cardiovascular disease. The main objective of present study was to estimate the serum levels of Cystatin C in individuals with normal BMI, and obese, aged between 18-39 Yrs and to compare the levels of serum Cystatin C among these individuals and to correlate the levels of serum Cystatin C with cardio metabolic risk factors. Material & Methods: The study population was taken from healthy volunteers of Mysore city, aged between 18- 39 years of either sex. The study population was divided into 2 groups based on BMI. Each group contains sample size of 45. Fasting serum sample was analyzed for Blood glucose, Total cholesterol, Total Triglycerides, Direct HDL cholesterol, Direct LDL Cholesterol by enzymatic method and serum Cystatin-C by immunoturbidimetric method using auto analyser. Results: The serum Cystatin C levels was significantly increased in obese groups, p value<0.001. The mean serum Cystatin C levels in normal BMI group was 0.78±0.03, and in Obese group is 1.15±0.09. In the study serum Cystatin C showed a positive correlation with serum glucose(r=0.61) serum triglycerides (r=0.7), Atherogenic index of plasma (AIP) (r=0.80), TCHOL: HDL (r=0.71), HDL: LDL (r=0.70) respectively and negative correlation with serum HDL (r=-0.52)
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