9. The Lobules
3 modes of architecture
• Classic Lobule – a hexagon with a central vein
in the middle and portal triad (hepatic artery,
portal vein, bile duct) at boundary points.
• Portal Lobule – connects 3 adjacent central
veins into a triangle; it follows bile drainage
• Liver acinus – diamond shaped and bordered
by 2 central veins and portal triads.
18. Bile
-Made by hepatocytes
-Drained into Bile ducts
-Moves in opposite direction from blood to portal triad
-Nasty stuff – Caniculi are bounded by tight junctions
22. Bile Canaliculus:
• holds bile
• btwn hepatocytes
• tight junctions
• communicates with bile duct
• flows in opposite direction of blood
Space of Disse:
• holds lymph
• communicates with sinusoids via
fenstrations and with Space of Moll
and lymphatics
23. Bile Canaliculus:
• holds bile
• btwn hepatocytes
• bounded by tight junctions
• communicates with bile duct
• flows in the opposite direction to
blood
Space of Disse:
• holds lymph
• communicates with sinusoids via
fenstrations and with Space of Moll
and lymphatics
• flows in the direction of blood
24. What is at the pointer?
Is it carrying blood/bile to/from hepatocytes?
