Pr bouchard

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all-in-web

Santé & Médecine Technologie

Charles Edouard Brown Sequard (1817- 1894)

INSULIN / IGFs Signaling KO GH KO GHRH KO GHR KO KO IGF1 KO IGF1-R KO IRS 1 & 2, PI3 K Yeasts, caenorhabditis elegans, insects, mice & centenarial model

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There is now a substantial body of evidence that indicates that GH Replacement Therapy has a beneficial effect upon many parameters: Body composition improves, lean mass increases, and fat mass decreases sgnificantly. ,[object Object],[object Object],[object Object],[object Object]

Swerdlow AJ, Higgins CD, Adlard P, Preece MA 2002 Risk of cancer in patients treated with 17 human pituitary growth hormone in the UK, 1959-85: a cohort study. Lancet 360:273-277 ,[object Object],[object Object],[object Object],[object Object],[object Object],HOWEVER

JCEM 2012 SAGhE : Safety and Appropriateness of Growth hormone treatments in Europe

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Growth Hormone Deficiency (GHD) can persist from childhood or be newly acquired. Confirmation through stimulation testing is usually required unless there is a proven genetic/structural lesion persistent from childhood. Growth harmone (GH) therapy offers benefits in body composition, exercise capacity, skeletal integrity, and quality of life measures and is most likely to benefit those patients who have more severe GHD. The risks of GH treatment are low. GH dosing regimens should be individualized. The final decision to treat adults with GHD requires thoughtful clinical judgment with a careful evaluation of the benefits and risks specific to the individual.

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The root cause of chronic diseases, cancer and aging is recently understood. It includes 1- A state of chronic low grade inflammation secondary to hyperglycemia and obesity leading to insulin resistance. 2- Mitochondrial dysfunction. Exercise play a significant rule in the salvage of these problems. Exercise is any bodily activity that enhances or maintain physical fitness and overall health, Exercise with its Countless Benefits is the logical salvage for a group of diseases related to inactivity . In view of the prevalence, global reach and health effect of these physical inactivity related diseases, the issue should be appropriately described as pandemic, with far-reaching health, economic, social and Environmental consequences.These diseases include, Obesity, Coronary artery disease, Diabetes, Hypertension, Cancer, Depression and anxiety, Arthritis, Osteoporosis, Etc, etc, etc… I think we have no option except doing regular exercises if we seriously searching for a salvage to escape the bad and serious consequences of these new life style diseases.

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