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Evaluation of bedside sonography
performed by emergency
physicians to detect
intussusception in children in the
emergency department
Tonson LaTour A1, Desjardins MP2, Gravel J2
1 Hôpitaux Universitaires de Genève, Geneva, Switzerland
2 CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada
All co-investigators have documented no
financial relationships to disclose or Conflicts of
Interest (COIs) to resolve
Disclosure
Background
•Intussusception
• Diagnosis by ultrasound sensitivity 98%
13 cases
12 cases
Study objective
• Evaluate POCUS by emergency physicians
with various levels of experience to detect
intussusception in children
Method
• Study design:
• A prospective cohort study
• Setting:
• A tertiary care pediatric ED
• CHU Sainte-Justine
• 2015-2018
Method
• Children
• A convenience sample
• Aged 0-5 years old
• Suspicion of intussusception according to the ED physician
• Request for a formal ultrasound
• Physicians
• Experienced in PEM
• Various training in POCUS
Method
• Intervention:
• 30 minutes theoretical training
• 30 minutes practical training
• POCUS on 3 patients
• Use linear probe
• 4 quadrants
Method
• Primary outcome
• Intussusception at radiology or surgery
Ethics
• All families provided verbal consent for the study
Results
Eligible
131
Intussusception
45
Physician not POCUS trained
107
Suspicion of intussusception
238
No intussusception
86
Results
multivariate predictors
POCUS Final
Diagnosis
Intussusception No intussusception Total
Intussusception
No intussusception
Inconclusive
Total 45 86 131
Results
multivariate predictors
POCUS Final
Diagnosis
Intussusception No intussusception Total
Intussusception 39
No intussusception 1
Inconclusive 5
Total 45 86 131Sensitivity: 0.87 (95%CI: 0.74-0.94)
Results
multivariate predictors
POCUS Final
Diagnosis
Intussusception No intussusception Total
Intussusception 39 3 42
No intussusception 1 55 56
Inconclusive 5 28 33
Total 45 86 131Sensitivity: 0.87 (95%CI: 0.74-0.94)
Specificity: 0.97 (95%CI: 0.90-0.99)
Results
multivariate predictors
POCUS Final
Diagnosis
Intussusception No intussusception Total
Intussusception 39 3 42
No intussusception 1 55 56
Inconclusive 5 28 33
Total 45 86 131Sensitivity: 0.98 (95%CI: 0.97-1.00)
Specificity: 0.94 (95%CI: 0.85-0.99)
Limitations
• Single centre study
• Children identified by treating physicians
• Small number of patients
Conclusion
• Excellent sensitivity and specificity of POCUS for
intussusception in children when performed by multiple
emergency physicians with variable POCUS
experience.
@graveljocelyn
Thank you!
@mp_desjardins
Baseline demographics of study participants
Patient who had POCUS
n= 131 (%)
Patient without
POCUS
N= 107 (%)
P-value*
Median age in month 18 (10-34) 27 (14-38) 0.03
Sex male 79 (0.60) 66 (0.62) 0.83
Abdominal pain 119 (0.91) 102 (0.95) 0.23
Unusual crying 110 (0.84) 90 (0.84) 0.34
Abdominal mass 12 (0.09) 2 (0.02) 0.02
Rectal bleeding 32 (0.24) 15 (0.24) 0.13
Past history of intussusception 12 (0.09) 7 (0.07) 0.49
Final Diagnosis
 Intussusception
 Gastro-enteritis
 Constipation
 Abdominal pain
 Mesenteric adenitis
 Other
 45 (0.34)
 20 (0.15)
 27 (0.21)
 12 (0.09)
 11 (0.08)
 16 (0.12)
 30 (0.28)
 20 (0.19)
 13 (0.12)
 16 (0.15)
 6 (0.06)
 22 (0.20)
0.24
POCUS by emergency physicians in comparison to
final outcome according to their experience
Final diagnosis
Intussusception No intussusception Total
Novice MD Intussusception 24 1 25
No intussusception 1 35 36
Inconclusive 5 22 27
Total 30 58 88
Experienced Intussusception 15 2 17
No intussusception 0 20 20
Inconclusive 0 6 6
Total 15 28 43
OR: 3.6
0.43-30.5
Pre and post test probability (from 0 to 1.00)
for children with intussusception
0
10
20
30
40
50
60
70
80
90
100
Pre Post
Pre and post test probability (from 0 to 1.00)
for children without intussusception
0
10
20
30
40
50
60
70
80
90
100
Pre Post

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Saem oral edu invagination (final)

  • 1. Evaluation of bedside sonography performed by emergency physicians to detect intussusception in children in the emergency department Tonson LaTour A1, Desjardins MP2, Gravel J2 1 Hôpitaux Universitaires de Genève, Geneva, Switzerland 2 CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada
  • 2. All co-investigators have documented no financial relationships to disclose or Conflicts of Interest (COIs) to resolve Disclosure
  • 3. Background •Intussusception • Diagnosis by ultrasound sensitivity 98% 13 cases 12 cases
  • 4. Study objective • Evaluate POCUS by emergency physicians with various levels of experience to detect intussusception in children
  • 5. Method • Study design: • A prospective cohort study • Setting: • A tertiary care pediatric ED • CHU Sainte-Justine • 2015-2018
  • 6. Method • Children • A convenience sample • Aged 0-5 years old • Suspicion of intussusception according to the ED physician • Request for a formal ultrasound • Physicians • Experienced in PEM • Various training in POCUS
  • 7. Method • Intervention: • 30 minutes theoretical training • 30 minutes practical training • POCUS on 3 patients • Use linear probe • 4 quadrants
  • 8. Method • Primary outcome • Intussusception at radiology or surgery
  • 9. Ethics • All families provided verbal consent for the study
  • 10. Results Eligible 131 Intussusception 45 Physician not POCUS trained 107 Suspicion of intussusception 238 No intussusception 86
  • 11. Results multivariate predictors POCUS Final Diagnosis Intussusception No intussusception Total Intussusception No intussusception Inconclusive Total 45 86 131
  • 12. Results multivariate predictors POCUS Final Diagnosis Intussusception No intussusception Total Intussusception 39 No intussusception 1 Inconclusive 5 Total 45 86 131Sensitivity: 0.87 (95%CI: 0.74-0.94)
  • 13. Results multivariate predictors POCUS Final Diagnosis Intussusception No intussusception Total Intussusception 39 3 42 No intussusception 1 55 56 Inconclusive 5 28 33 Total 45 86 131Sensitivity: 0.87 (95%CI: 0.74-0.94) Specificity: 0.97 (95%CI: 0.90-0.99)
  • 14. Results multivariate predictors POCUS Final Diagnosis Intussusception No intussusception Total Intussusception 39 3 42 No intussusception 1 55 56 Inconclusive 5 28 33 Total 45 86 131Sensitivity: 0.98 (95%CI: 0.97-1.00) Specificity: 0.94 (95%CI: 0.85-0.99)
  • 15. Limitations • Single centre study • Children identified by treating physicians • Small number of patients
  • 16. Conclusion • Excellent sensitivity and specificity of POCUS for intussusception in children when performed by multiple emergency physicians with variable POCUS experience.
  • 18. Baseline demographics of study participants Patient who had POCUS n= 131 (%) Patient without POCUS N= 107 (%) P-value* Median age in month 18 (10-34) 27 (14-38) 0.03 Sex male 79 (0.60) 66 (0.62) 0.83 Abdominal pain 119 (0.91) 102 (0.95) 0.23 Unusual crying 110 (0.84) 90 (0.84) 0.34 Abdominal mass 12 (0.09) 2 (0.02) 0.02 Rectal bleeding 32 (0.24) 15 (0.24) 0.13 Past history of intussusception 12 (0.09) 7 (0.07) 0.49 Final Diagnosis  Intussusception  Gastro-enteritis  Constipation  Abdominal pain  Mesenteric adenitis  Other  45 (0.34)  20 (0.15)  27 (0.21)  12 (0.09)  11 (0.08)  16 (0.12)  30 (0.28)  20 (0.19)  13 (0.12)  16 (0.15)  6 (0.06)  22 (0.20) 0.24
  • 19. POCUS by emergency physicians in comparison to final outcome according to their experience Final diagnosis Intussusception No intussusception Total Novice MD Intussusception 24 1 25 No intussusception 1 35 36 Inconclusive 5 22 27 Total 30 58 88 Experienced Intussusception 15 2 17 No intussusception 0 20 20 Inconclusive 0 6 6 Total 15 28 43 OR: 3.6 0.43-30.5
  • 20. Pre and post test probability (from 0 to 1.00) for children with intussusception 0 10 20 30 40 50 60 70 80 90 100 Pre Post
  • 21. Pre and post test probability (from 0 to 1.00) for children without intussusception 0 10 20 30 40 50 60 70 80 90 100 Pre Post

Notes de l'éditeur

  1. Thank you
  2. We have no conflict of interest
  3. We all know that Intussusception is a medical emergency and that the diagnosis is usually made in radiology by ultrasound. Two previous studies suggested that POCUS could be used to help ED physicians diagnose intussusception. However, these studies were small and the total number of cases was 25
  4. The primary objective of this study was to Evaluate the ability of emergency physicians with various levels of POCUS experience to detect intussusception with bedside ultrasound among children
  5. This was a prospective cohort study conducted at Sainte-Justine Hospital. A tertiary care pediatric hospital. Recruitment occurred during 3 years
  6. There was two level of participants First, patients were a convenience sample of children aged 0-5 years old for whom the treating physicians requested a formal ultrasound from radiology for a possible intussusception. Physicians were also considered as participants because we evaluated their performance. To be included, a physician had to have minimal experience in POCUS and received a 1-hour specific training on intussusception
  7. This training included a 30 minutes power point presentation on POCUS and intussusception. Then, physicians practice the technique on 3 children. The ultrasound was performed using a linear probe. And we evaluated the 4 quadrants starting on the right lower quadrants.
  8. The primary outcome was intussusception confirmed at radiology or surgery.
  9. All families provided verbal consent for the study
  10. During the study period, a total of 238 children had a suspicion of intussusception. Of these, 107 were seen by a physician not trained in Intussusception POCUS so they were excluded leading to 131 included children. Of these, there were 45 intussusception. A total of 24 physicians evaluated at least one patient.
  11. This is the table with the primary results. As mentioned, there were 45 intussusceptions and 86 control
  12. The physicians identified 39 of 45 intussusceptions, they wrongly said there was non intussusception in 1 children and it was inconclusive in 5. This leads to a sensitivity of at least 87%
  13. Of the 86 patients without intussusception, it was inconclusive or negative in 83 children for a specificity of 97%
  14. If you remove the 33 patients for whom it was inconclusive, the sensitivity and specificity were of 98 and 94%
  15. There are limitations to our study. First, it was conducted in a single setting. Physicians in this setting have an excellent experience in PEM. The most important limitation is the use of a convenience sample. It is possible that physicians only included children for whom they were more sure about their POCUS evaluation. We don’t think this happened but we cannot be 100% sure. Finally, the sample size was rather small but this is larger than the previous studies including 12 and 13 cases.
  16. IN conclusion, our study demonstrated an Excellent sensitivity and specificity of POCUS for intussusception in children when performed by multiple emergency physicians with variable POCUS experience
  17. I will now be happy to take your questions and thank you for your attention