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In chronic superficial ulcerations, the thickness of the epithelium is increased and we observe zones of detachement and an increased density of the proximal stroma. These observations are similar to those collected with traditionnal histology.
When the ulceration is deeper, we oberve an increased density of the stroma around the ulceration.
The depth of stromal involvement can be measured, and we can see a localized corneal fibrosis made visible by the increase of the corneal density with a strong absorption of the IR beam.
A normal anterior chamber does not appear in OCT.
However, in pathological conditions, we can identify the presence of blood or fibrin clots, and in this case of anterior uveitis, Tyndall effects and retrokeratic precipitates.
We have also evaluated OCT imaging in surgical conditions. As you can see, we can measure residual stromal thickness after a superficial keratectomy : this helps in the choice of the surgical technique. We can also follow the healing process after surgeries like conjonctival or vetbiosis grafts.