Avancées et nouveaux paradigmes en recherche clinique - Jean-Yves BLAY - Renc...PharmaSuccess
This document discusses new paradigms in clinical research. It notes that tumor biology is increasingly being understood at the molecular level, leading to a fragmentation of disease entities. Clinical trials now aim to target primary molecular alterations in tumors. Examples discussed include targeting KIT mutations in GIST and VEGF production as a secondary event. The document advocates understanding unexpected drug responses and evaluating pharmacodynamics. It concludes that understanding disease biology, molecular diagnostics, targeting primary alterations, and international collaboration are key to advances in clinical research.
Avancées et nouveaux paradigmes en recherche clinique - Jean-Yves BLAY - Renc...PharmaSuccess
This document discusses new paradigms in clinical research. It notes that tumor biology is increasingly being understood at the molecular level, leading to a fragmentation of disease entities. Clinical trials now aim to target primary molecular alterations in tumors. Examples discussed include targeting KIT mutations in GIST and VEGF production as a secondary event. The document advocates understanding unexpected drug responses and evaluating pharmacodynamics. It concludes that understanding disease biology, molecular diagnostics, targeting primary alterations, and international collaboration are key to advances in clinical research.
Recherche translationnelle et maladies métaboliques - Philippe FROGUEL - Renc...PharmaSuccess
The document discusses the lack of personalized treatment approaches for diabetes over the past 30+ years and the potential for genetic sequencing and stem cell technologies to enable truly personalized diabetic care. Specifically:
- Currently, all diabetics receive metformin initially, but there are no agreed guidelines for alternative treatments if metformin fails.
- Recent advances in genetic sequencing allow for better characterization of familial diabetes cases and improved management.
- Sequencing the genome and using reprogrammed stem cells can help advance toward personalized diabetic medicine and understanding disease complications at the individual level.
Film sur le marketing digital:
1 - La révolution digitale
2 - La communication digitale
3 - Relation client et technologies numériques
4 - Le commerce digitalisé
Génération Y et bouleversement de la valeur marchandeDorian Dawance
The following study aims at better understanding generation Y consumers and their price perception in order to determine the pricing strategy that suits them best. However important this topic might be for businesses, there are only a handful of papers addressing it, especially in France where the research stream is inexistent. Based on a survey of 134 Y-ers, this paper shows how US research and French literature match an existing generation Y consumer group in France. It reveals how the current price fuzziness affects their reference price formation and shows that time is a variable that should not be underestimated when addressing this consumer segment. This paper ends with an executive summary for marketers.
Recherche translationnelle et maladies métaboliques - Philippe FROGUEL - Renc...PharmaSuccess
The document discusses the lack of personalized treatment approaches for diabetes over the past 30+ years and the potential for genetic sequencing and stem cell technologies to enable truly personalized diabetic care. Specifically:
- Currently, all diabetics receive metformin initially, but there are no agreed guidelines for alternative treatments if metformin fails.
- Recent advances in genetic sequencing allow for better characterization of familial diabetes cases and improved management.
- Sequencing the genome and using reprogrammed stem cells can help advance toward personalized diabetic medicine and understanding disease complications at the individual level.
Film sur le marketing digital:
1 - La révolution digitale
2 - La communication digitale
3 - Relation client et technologies numériques
4 - Le commerce digitalisé
Génération Y et bouleversement de la valeur marchandeDorian Dawance
The following study aims at better understanding generation Y consumers and their price perception in order to determine the pricing strategy that suits them best. However important this topic might be for businesses, there are only a handful of papers addressing it, especially in France where the research stream is inexistent. Based on a survey of 134 Y-ers, this paper shows how US research and French literature match an existing generation Y consumer group in France. It reveals how the current price fuzziness affects their reference price formation and shows that time is a variable that should not be underestimated when addressing this consumer segment. This paper ends with an executive summary for marketers.
Nouvelles exigences en pharmacovigilance - Aprova - Rencontres de la Recherch...PharmaSuccess
1) The document discusses new pharmacovigilance requirements in clinical trials in the European Union. It emphasizes the important role of investigators in ensuring patient safety and their responsibilities in reporting adverse events and serious adverse events.
2) Thalidomide is provided as a historical example of the importance of pharmacovigilance, as its teratogenic effects in the 1960s led to the creation of pharmacovigilance regulations. Vioxx is also discussed as a more recent example of post-market safety issues emerging.
3) The presentation provides guidance to investigators on proper adverse event reporting, including defining adverse events and serious adverse events, assessing causality, completing reporting forms, and timelines for reporting serious
Recherche clinique en cardiologie interventionnelle - Gilles MONTALESCOT - Re...PharmaSuccess
This document discusses clinical research in interventional cardiology conducted by the ACTION network in France. It summarizes several studies, including the ATOLL trial which compared enoxaparin to unfractionated heparin in STEMI patients undergoing primary PCI, finding a reduction in bleeding with enoxaparin. It also discusses the ARCTIC trial which evaluated platelet function monitoring after PCI and found no benefit to adjustment of antiplatelet therapy based on monitoring. The network aims to conduct large, high quality clinical trials to advance interventional cardiology treatments and addresses challenges in patient recruitment.
Digital et newbusiness model : beyond the pill - Patrice CARAYON - PharmaSuccess 2014
1. Speaker :
Ne peut être diffusé sans citation de la source : www. nextgeneration.fr
Patrice CARAYON
Vice President Strategy & Business
Development
Business, Human & Digital transformation of
pharmaceutical industry
UPSA operating feedback’s capitalization
2. UPSA paradigm change : Disruptive transformation
UPSA
Gouvernance Command & Control Connect & Collaborate
Business Model
Environment Stable Unstable
Pattern-centric B2B2C chain-centric
Ressources R&D Intelligence/Knowledge
Main goal
Acquire Key Success
Factors
Constant Transformation
/ Agility
Strategy Positioning :
Secure market’s positions
Movement :
Change/create game’s rules
UPSA NextGeneration
Ne peut être diffusé sans citation de la source : www. nextgeneration.fr
3. Sharing experience of UPSA transformation
Business, human and digital transformation.
UPSA
Internal constraints
External constraints
Ne peut être diffusé sans citation de la source : www. nextgeneration.fr
4. Sharing experience of UPSA transformation
Business, human and digital transformation.
UPSA
1. Space of
liberty and
creativity
Internal constraints
External constraints
Ne peut être diffusé sans citation de la source : www. nextgeneration.fr
5. Sharing experience of UPSA transformation
Business, human and digital transformation.
UPSA
3. Shared vision
1. Space of
liberty and
creativity
Internal constraints
External constraints
2. Intelligence
/Knowledge
Ne peut être diffusé sans citation de la source : www. nextgeneration.fr
6. Sharing experience of UPSA transformation
Business, human and digital transformation.
UPSA
3. Shared vision
1. Space of
liberty and
creativity
4. New strategic areas
(physical/digital ecosytem)
2. Intelligence
/Knowledge
Ne peut être diffusé sans citation de la source : www. nextgeneration.fr
7. Thank you for your attention
Patrice CARAYON
patrice.carayon@bms.com
www.bms.fr
Contacts :
Louis SANTOS
+33 (0)6 47 92 06 17
+33 (0)1 84 06 44 46
75015 Paris
louis.santos@nextgeneration.fr
www.nextgeneration.fr
Ne peut être diffusé sans citation de la source : www. nextgeneration.fr