1. SÉMINAIRE de SCIENCES CLINIQUES Salah EL MOUSTAGHFIR, dmv Dégradation gastrique des Pill Pockets ® : Étude randomisée avec contrôle

12. T 15 sec G T 5min G T 1h G T 1h P T 5min P T 5min P

13. P T 0 T 4h T 5h T 3h

14. RÉSULTATS

20. BIBLIOGRAPHIE 1. Feldman M, Smith HJ, Simon TR. Gastric emptying of solid radiopaque markers: studies in healthy subjects and diabetic patients. Gastroenterology 1984;87:895-902. 2. Hall JA, Willer RL, Seim HB, et al. Gastric emptying of nondigestible radiopaque markers after circumcostal gastropexy in clinically normal dogs and dogs with gastric dilatation-volvulus. American journal of veterinary research 1992;53:1961-1965. 3. Kararli TT. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharmaceutics & drug disposition 1995;16:351-380. 4. Wei H, Qing D, De-Ying C, et al. Pectin/Ethylcellulose as film coatings for colon-specific drug delivery: preparation and in vitro evaluation using 5-fluorouracil pellets. PDA journal of pharmaceutical science and technology 2007;61:121-130. 5. Bennett AD, MacPhail CM, Gibbons DS, et al. A comparative study evaluating the esophageal transit time of eight healthy cats when pilled with the FlavoRx pill glide versus pill delivery treats. Journal of Feline Medicine & Surgery ;12:286-290. 6. Kinget R, Kalala W, Vervoort L, et al. Colonic Drug Targeting. Journal of Drug Targeting 1998;6:129-149. 7. Sutton SC. Companion animal physiology and dosage form performance. Advanced Drug Delivery Reviews 2004;56:1383-1398. 8. He W, Fan L-F, Du Q, et al. Design and in vitro/in vivo evaluation of multi-layer film coated pellets for omeprazole. Chemical & pharmaceutical bulletin 2009;57:122-128. 9. Scrivani PV, Bednarski RM, Myer CW. Effects of acepromazine and butorphanol on positive-contrast upper gastrointestinal tract examination in dogs. American Journal of Veterinary Research 1998;59:1227-1233. 10. Bonadio CM, Pollard RE, Dayton PA, et al. Effects of Body Positioning on Swallowing and Esophageal Transit in Healthy Dogs. Journal of Veterinary Internal Medicine 2009;23:801-805. 11. Graham JP, Lipman AH, Newell SM, et al. Esophageal transit of capsules in clinically normal cats. American Journal of Veterinary Research 2000;61:655-657. 12. Westfall DS, Twedt DC, Steyn PF, et al. Evaluation of esophageal transit of tablets and capsules in 30 cats. Journal of Veterinary Internal Medicine 2001;15:467-470. 13. Schulze JDR, Peters EE, Vickers AW, et al. Excipient effects on gastrointestinal transit and drug absorption in beagle dogs. International Journal of Pharmaceutics 2005;300:67-75. 14. Martinez M, Papich M. Factors influencing the gastric residence of dosage forms in dogs. Journal of Pharmaceutical Sciences 2009;98:844-860. 15. Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release 2000;63:235-259.

21. BIBLIOGRAPHIE 16. Nap RC, Breen DJ, Lam TJ, et al. Gastric retention of enteric-coated aspirin tablets in beagle dogs. Journal of veterinary pharmacology and therapeutics 1990;13:148-153. 17. Aoyagi N, Ogata H, Kaniwa N, et al. Gastric emptying of tablets and granules in humans, dogs, pigs, and stomach-emptying-controlled rabbits. Journal of Pharmaceutical Sciences 1992;81:1170-1174. 18. Kaniwa N, Aoyagi N, Ogata H, et al. Gastric emptying rates of drug preparations. I. Effects of size of dosage forms, food and species on gastric emptying rates. Journal of pharmacobio-dynamics 1988;11:563-570. 19. Gao C, Huang J, Jiao Y, et al. In vitro release and in vivo absorption in beagle dogs of meloxicam from Eudragit® FS 30 D-coated pellets. International Journal of Pharmaceutics 2006;322:104-112. 20. Weber M, Stambouli F, Martin L, et al. Influence of age and body size on gastrointestinal transit time of radiopaque markers in healthy dogs. American journal of veterinary research 2002;63:677-682. 21. Mills D, Cracknell N. Management of fear of fireworks in dogs. The Veterinary record 2005;157:564-564. 22. Choe SY, Neudeck BL, Welage LS, et al. Novel method to assess gastric emptying in humans: the Pellet Gastric Emptying Test. European Journal of Pharmaceutical Sciences 2001;14:347-353. 23. Hey H, Jrgensen F, Srensen K, et al. Oesophageal transit of six commonly used tablets and capsules. British medical journal (Clinical research ed 1981) 1982;285:1717-1719. 24. Thombre AG. Oral delivery of medications to companion animals: palatability considerations. Advanced Drug Delivery Reviews 2004;56:1399-1413. 25. Saffran M, Field JB, Pea J, et al. Oral insulin in diabetic dogs. The Journal of endocrinology 1991;131:267-278. 26. Pollard R, Marks S, Leonard R, et al. Preliminary evaluation of the pharyngeal constriction ratio (PCR) for fluoroscopic determination of pharyngeal constriction in dysphagic dogs. Veterinary radiology & ultrasound 2007;48:221-226. 27. Pollard RE, Marks SL, Davidson A, et al. Quantitative videofluoroscopic evaluation of pharyngeal function in the dog. Veterinary radiology & ultrasound 2000;41:409-412. 28. Krishnaiah YSR, Bhaskar Reddy PR, Satyanarayana V, et al. Studies on the development of oral colon targeted drug delivery systems for metronidazole in the treatment of amoebiasis. International Journal of Pharmaceutics 2002;236:43-55. 29. He W, Du Q, Cao D-Y, et al. Study on colon-specific pectin/ethylcellulose film-coated 5-fluorouracil pellets in rats. International Journal of Pharmaceutics 2008;348:35-45. 30. Kalantzi L, Polentarutti B, Albery T, et al. The delayed dissolution of paracetamol products in the canine fed stomach can be predicted in vitro but it does not affect the onset of plasma levels. International Journal of Pharmaceutics 2005;296:87-93.

22. QUESTIONS