Le HDL-c, où en est-on aujourd’hui ? par John Chapmanall-in-web
This document summarizes a presentation given by Dr. M. John Chapman on HDL-C (high-density lipoprotein cholesterol). It discusses the structure and composition of HDL particles, their role in reverse cholesterol transport from tissues to the liver, and functions such as promoting cholesterol efflux from cells. While HDL-C level is commonly used clinically, Dr. Chapman questions whether it accurately reflects HDL functionality in protecting against cardiovascular disease. The document presents evidence that HDL's ability to efflux cholesterol from macrophages better predicts atherosclerosis and coronary artery disease than HDL-C level alone.
Le HDL-c, où en est-on aujourd’hui ? par John Chapmanall-in-web
This document summarizes a presentation given by Dr. M. John Chapman on HDL-C (high-density lipoprotein cholesterol). It discusses the structure and composition of HDL particles, their role in reverse cholesterol transport from tissues to the liver, and functions such as promoting cholesterol efflux from cells. While HDL-C level is commonly used clinically, Dr. Chapman questions whether it accurately reflects HDL functionality in protecting against cardiovascular disease. The document presents evidence that HDL's ability to efflux cholesterol from macrophages better predicts atherosclerosis and coronary artery disease than HDL-C level alone.